Nano Electronics and Computer Science Research Group

This is the website for the Nano Research group based at the University of Southampton ECS department, and details current research topics and the people connected with these. It shows some of the current research topics undertaken at the center, and gives an outline of what can be done for post graduate courses.

PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a negative regulator of T-cell activation associated with several autoimmune diseases, including systemic lupus erythematosus (SLE). Missense rs2476601 is associated with SLE in individuals with European ancestry. Since the rs2476601 risk allele frequency differs dramatically across ethnicities, we assessed robustness of PTPN22 association with SLE and its clinical subphenotypes across four ethnically diverse populations. Ten SNPs were genotyped in 8220 SLE cases and 7369 controls from in European-Americans (EA), African-Americans (AA), Asians (AS), and Hispanics (HS). We performed imputation-based association followed by conditional analysis to identify independent associations. Significantly associated SNPs were tested for association with SLE clinical sub-phenotypes, including autoantibody profiles. Multiple testing was accounted for by using false discovery rate. We successfully imputed and tested allelic association for 107 SNPs within the PTPN22 region and detected evidence of ethnic-specific associations from EA and HS. In EA, the strongest association was at rs2476601 (P = 4.761029, OR = 1.40 (95% CI = 1.25–1.56)). Independent association with rs1217414 was also observed in EA, and both SNPs are correlated with increased European ancestry. For HS imputed intronic SNP, rs3765598, predicted to be a cis-eQTL, was associated (P = 0.007, OR = 0.79 and 95% CI = 0.67–0.94). No significant associations were observed in AA or AS. Case-only analysis using lupus-related clinical criteria revealed differences between EA SLE patients positive for moderate to high titers of IgG anti-cardiolipin (aCL IgG .20) versus negative aCL IgG at rs2476601 (P = 0.012, OR = 1.65). Association was reinforced when these cases were compared to controls (P = 2.761025, OR = 2.11). Our results validate that rs2476601 is the most significantly associated SNP in individuals with European ancestry. Additionally, rs1217414 and rs3765598 may be associated with SLE. Further studies are required to confirm the involvement of rs2476601 with aCL IgG.

Three substituted 4-pyrazolylbenzoates: hydrogen-bonded supramolecular structures in one, two and three dimensions

The molecules of ethyl 4-(5-amino-3-methyl-1H-pyrazol-1yl) benzoate, C13H15N3O2, are linked by two independent N-H center dot center dot center dot O hydrogen bonds into a chain of edge-fused and alternating R-4(2)(8) and R-2(2)(20) rings. A combination of N-H center dot center dot center dot N and N-H center dot center dot center dot O hydrogen bonds links the molecules of methyl 4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl) benzoate, C15H19N3O2, into sheets of alternating R-2(2)(20) and R-6(6)(32) rings. In 4-(5-amino-3-methyl-1H-pyrazol-1-yl) benzoic acid monohydrate, C11H11N3O2 center dot H2O, the molecular components are linked into a three-dimensional framework structure by a combination of five independent hydrogen bonds, two of O-H center dot center dot center dot N type and one each of O-H center dot center dot center dot O, N-H center dot center dot center dot O and N-H center dot center dot center dot N types

Turing’s imitation game and human thought

In 1950, the English mathematician Alan Mathison Turing proposed the basis of what some authors consider the test that a machine must pass to establish that it can think. This test is basically a game; nevertheless, it has had great infl uence in the development of the theories of the mind performance. The game specifications and some of its repercussions in the conception of thinking, the consciousness and the human will, will be ramifications of the path that will take us through the beginning of the artificial intelligence, passing along some of its singular manifestations, to culminate in the posing of certain restrictions of its fundaments.

Art and human nature

This article presents a visual artist’s point of view about art. This view confronts the Eurocentric traditional cannon with some ignored, but valuable traditions, thus proposing a contra-canon. These ideas are examined on the light of a variety of sources, including prehistoric, pre-Columbian, and 20th century art expressions, in a variety of media, from sculpture to literature. Recent art expressions are characterized by their incorporation of minority values and perspectives that challenge “universal” views. Using samples of works from Latino and African American artists, the author shows that, even today, art is a means to know the world and its people, to exhibit personal life, to create personal symbolism, and to show one’s identity or the search for it. Like the human nature it represents, art has multiple faces.

Doing and using educational research : engaging researchers, practitioners and policy makers in productive partnerships. 'Haciendo y usando la investigación educativa : involucrando investigadores, docentes y diseñadores de políticas en asociaciones productivas'.

Resumen de la autora. Este artículo pertenece al monográfico 'John Elliott: su pensamiento y su influencia'

Climate change, ethics and human security.

Este texto, escrito por expertos internacionales, sostiene que el cambio climático debe considerarse como una cuestión de seguridad humana y no como un problema ambiental que pueda gestionarse en solitario. Muestra el concepto de seguridad humana con un nuevo enfoque ligado a los desafíos que el cambio climático ofrece a la humanidad, así como da respuestas para un futuro más equitativo y sostenible para las próximas generaciones. El cambio climático, la ética y la seguridad humana serán de interés para los investigadores, los responsables políticos y los profesionales interesados con las dimensiones humanas del cambio climático, así como para los estudiantes de nivel superior en ciencias sociales y humanidades preocupados por este problema.

The adult learner : the definitive classic in adult education and human resource development.

Es una lectura esencial para los profesionales del aprendizaje de adultos, estudiantes y profesionales de los recursos humanos, pues proporciona un marco teórico para la comprensión de los problemas del aprendizaje de adultos, tanto en los entornos docentes como en los lugares de trabajo. Se divide en tres partes: la primera parte estudia 'Las raíces de la andragogía', se traza el desarrollo de esta teoría y las características de los estudiantes adultos; en la segunda parte 'Los avances en el aprendizaje de adultos', se explican sus perspectivas de futuro en la investigación y la práctica y, en la última parte, 'Practica en el aprendizaje de adultos', se presentan lecturas seleccionadas que desarrollan los aspectos específicos de la andragogía en la práctica y que incluye estrategias para implementar los supuestos básicos, para adaptar el aprendizaje a las diferencias individuales, y para implementar la educación de adultos en las organizaciones. De especial interés son dos instrumentos de autoevaluación, 'the Core Competency Diagnostic and Planning Guide' y 'the Personal Adult Learning Style Inventory' que permiten al lector ponerse en camino del desarrollo personal en el aprendizaje de adultos.

Research-based teaching and learning (RBTL) : a paradigm for enhancing teaching and learning at research universities

Resumen basado en el de la publicaci??n