920 resultados para Silva, Antonio José da, 1705-1739
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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The surface free energy of conditioned-dentin is one of the factors that interfere with monomeric infiltration of the interfibrillar spaces. Saturation of the tooth matrix with different substances may modulate this energy and, consequently, the wettability of the dentin. To evaluate the influence of different substances used to saturate conditioned-dentin on surface free energy (SFE) of this substrate. Dentin blocks (4 × 7 × 1 mm, n = 6/ group), obtained from the roots of bovine incisors, were etched using phosphoric acid for 15 seconds, rinsed and gently dried. The surfaces were treated for 60 seconds with: ultra-purified water (H20-control); ethanol (EtOH), acetone (ACT), chlorhexidine (CHX), ethylenediaminetetraacetic acid (EDTA); or sodium hypochlorite (NaOCl). The tooth surfaces were once again dried with absorbent paper and prepared for SFE evaluation using three standards: water, formamide and bromonaphthalene. Analysis of variance (ANOVA) and Dunnet's tests (a = 0.05) were applied to the data. Ethylenediaminetetraacetic acid was the only substance that caused a change to the contact angle for the standards water and formamide, while only EtOH influenced the angles formed between formamide and the dentin surface. None of the substances exerted a significant effect for bromonaphtha-lene. In comparison to the control, only EDTA and NaOCl altered both polar components of the SFE. Total SFE was increased by saturation of the collagen matrix by EDTA and reduced when NaOCl was used. Saturation of the collagen matrix by EDTA and EtOH changed the surface free energy of the dentin. In addition, the use of NaOCl negatively interfered with the properties evaluated. The increase of surface free energy and wettability of the dentin surface would allow higher penetration of the the adhesive system, which would be of importance to the clinical success of resin-dentin union.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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The human enzyme dihydroorotate dehydrogenase (HsDHODH) has been studied for being a target for development of new antineoplasic and antiproliferative drugs. The synthetic peptide N-t(DH) represents the N-terminal microdomain of this enzyme, responsible for anchoring it to the inner mitochondrial membrane. Also, it is known to harbor quinones that are essential for enzyme catalysis. Here we report structural features of the peptide/membrane interactions obtained by using CD and DEER spectroscopic techniques, both in micelles and in lipid vesicles. The data revealed different peptide conformational states in micelles and liposomes, which could suggest that this microdomain acts in specific regions or areas of the mitochondria, which can be related with the control of the quinone access to the HsDHODH active site. This is the first study to report on conformational changes of the HsDHODH N-terminal microdomain through a combination of CD and DEER spectroscopic techniques.
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The present study offers a parasitological analysis of juvenile individuals of the green turtle (Chelonia mydas) found on the Brazilian coast between 2004 and 2011. Helminths were found in 90 out of 136 individuals (66.2%, CI= 57.7 - 74.0). In total, 29,411 helminths were collected, belonging to the families Brachycoeliidae, Cladorchiidae, Microscaphidiidae, Pronocephalidae, Rhytidodidae, and Spirorchiidae. Mean species richness was 4.74 (CI= 4.03 - 5.46), the mean intensity was 327 (CI= 223 - 489) the mean abundance was 216 (CI= 146 - 339). This study also reports new geographical records for: Angiodictyum longum, Angiodictyum parallelum, Rameshwarotrema uterocrescens, Pyelosomum cochlear, Schizamphistomum scleroporum, Cymatocarpus solearis and Neospirorchis sp. This is the first analysis of helminths composition in juveniles of green turtles.
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A complete morphological description, supported by molecular data, of Clinostomum detruncatum metacercariae is reported in this study. The metacercariae were found infecting Synbranchus marmoratus from the Paraná River, municipality of GuaÃ-ra, Paraná State, Brazil. The taenioidean uterus is the main morphological characteristic of this species. Both Neighbour-Joining (NJ) and Maximum Likelihood (ML) trees showed 2 clear separate clusters grouping together the species from the Palearctic region (Clinostomum complanatum, Clinostomum cutaneum, Clinostomum phalacrocoracis, Clinostomum philippinense) and from the Nearctic/Neotropical regions (Clinostomum marginatum, Clinostomum tataxumui, C. detruncatum, Clinostomum sp. 7). The latter clade is divided into 2 subclades grouping species from North America and Mexico (C. marginatum and C. tataxumui), and from Brazil (C. detruncatum and Clinostomum sp. 7).
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In this paper I discuss Husserl's solution of the problem of imaginary elements in mathematics as presented in the drafts for two lectures he gave in Göttingen in 1901 and other related texts of the same period, a problem that had occupied Husserl since the beginning of 1890, when he was planning a never published sequel to Philosophie der Arithmetik (1891). In order to solve the problem of imaginary entities Husserl introduced, independently of Hilbert, two notions of completeness (definiteness in Husserl's terminology) for a formal axiomatic system. I present and discuss these notions here, establishing also parallels between Husserl's and Hilbert's notions of completeness. © 2000 Kluwer Academic Publishers.
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Pós-graduação em Engenharia Mecânica - FEG
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Purpose: The aim of this study was to assess the contributions of some prosthetic parameters such as crown-to-implant (C/I) ratio, retention system, restorative material, and occlusal loading on stress concentrations within a single posterior crown supported by a short implant. Materials and Methods: Computer-aided design software was used to create 32 finite element models of an atrophic posterior partially edentulous mandible with a single external-hexagon implant (5 mm wide × 7 mm long) in the first molar region. Finite element analysis software with a convergence analysis of 5% to mesh refinement was used to evaluate the effects of C/I ratio (1:1; 1.5:1; 2:1, or 2.5:1), prosthetic retention system (cemented or screwed), and restorative material (metal-ceramic or all ceramic). The crowns were loaded with simulated normal or traumatic occlusal forces. The maximum principal stress (σmax) for cortical and cancellous bone and von Mises stress (σvM) for the implant and abutment screw were computed and analyzed. The percent contribution of each variable to the stress concentration was calculated from the sum of squares analysis. Results: Traumatic occlusion and a high C/I ratio increased stress concentrations. The C/I ratio was responsible for 11.45% of the total stress in the cortical bone, whereas occlusal loading contributed 70.92% to the total stress in the implant. The retention system contributed 0.91% of the total stress in the cortical bone. The restorative material was responsible for only 0.09% of the total stress in the cancellous bone. Conclusion: Occlusal loading was the most important stress concentration factor in the finite element model of a single posterior crown supported by a short implant.
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The packaging often presents faults that difficult the communication between product and consumer. The aim of this research is to study the interaction between a group of elderly people with five food packagings, that being illinterpreted, can bring them health problems. The results of this study evidence the importance of ergonomics in graphic design for food packaging.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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This work presents the results of the efficiency of three protection methods of roads slopes, against the development of erosion processes.The methods anlyzed were: (1) grass planting "San Carlos" (Axonopus compressus), (2) litter, composed of remains of branches and leaves of eucalyptus E. Grandis, and (3) Compacted soil cover with a local soil with properties more resistant to erosion processes.The experiment consisted of assembly of four rectangular cells with 6 meters, three for protection systems in study and one was kept unprotected to evaluate the efficiency of the methods in study.The determination of the amount of eroded sediment was based on the sum of the solids in suspension and stored sediments in the geotextile bags.The results showed that, compared to the unprotected cell, the litter obtained a reduction of soil loss of 90%, while the grass enveloped and reduced 80% and 65% respectively.
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The purpose of this study is to characterize the geological subsurface structure of the diabase sill of the Paraná Magmatic Province intruded in the Itararé Group, located near the city of Limeira, in the east-central region of São Paulo state. The magnetometric method served as an important tool defining the igneous body in view of the great contrast between the physical properties of the diabase sill and the host sandstones. Previous cartographic data signaled in region a possible lateral continuity in subsurface, of the various sills that occur in the region. However, the magnetic data obtained herein indicate that the area of occurrence of this body is very restricted and independent of the others observed in the region. The analysis of the radial average power spectrum obtained allowed determine the interval of number of waves adequate for the separation of shallow and deep sources, and thus conclude that the sill of the Limeira region is located more than 100 m deep.