994 resultados para Reference sites
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Sumário O presente trabalho de Memória intitulado “Publicidade na Internet: Análise comparativa da publicidade nos sites de três jornais online em Cabo Verde”, realiza-se no âmbito da conclusao de licenciatura em Ciências da Comunicação variante publicidade na Universidade conclusão Jean Piaget de Cabo Verde. m meio importante publicidade. Pretende-se determinar que recursos da Internet estão a ser Objectiva-se com este trabalho, compreender até que ponto a Internet é u para a veiculação de aproveitados e aplicados pelos anunciantes em Cabo Verde para fazerem as suas online e que tipos serviços os jornais oferecem aos seus clientes ou anunciantes. A anális será feita tendo como base os parâmetros como os tipos de publicidade online, as suas form de comércio e os tipos de interactividade oferecida. Será efectuada uma an publicidade online feita actualmente em Cabo Verde, confrontando com como meio publicitário e com alguns estudos desenvolvidos anteriorment em Cabo Verde. divulgações e as álise crítica sobre a o potencial da web e sobre este assunto em Cabo Verde.
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Nos últimos anos, Cabo verde tem estado a apostar fortemente nas Tecnologias de Informação e Comunicação, com grande foco na governação electrónica, e conseguintemente na disponibilização de informações e serviços aos cidadãos através de sites, aplicações Web e outros meios. Neste contexto, torna-se necessário que esses websites e aplicações estejam dotados de mecanismos capazes de minimizar os riscos de eventuais cyberataques. Este artigo analisa as principais vulnerabilidades existentes nos sites das instituições do governo de Cabo Verde, e apresenta recomendações sobre as medidas que deverão ser implementadas para minimizar esses problemas.
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A usabilidade é um conceito que ultrapassa as fronteiras de aprendizagem ou da facilidade de uso. É um termo mais vasto e envolve vários critérios para medi-la. Diversos estudos proeminentes foram desenvolvidos, cada um dispondo de um conjunto de métricas com o propósito de avaliar a usabilidade. O presente trabalho monográfico versa o estado actual da usabilidade dos sites governamentais em Cabo Verde, bem como adoptar alguns métodos de avaliação de entre os vários existentes, que permita fazer uma avaliação crítica dos sites governamentais. Tendo em consideração a importância que os sites governamentais têm para a população, é preciso que se encontrem bem estruturados para que os cidadãos cabo-verdianos e não só, se sintam satisfeitos e confortáveis ao navegar por eles e que realizem as suas tarefas em curto espaço de tempo. Neste sentido, foram seleccionados os dez sites mais representativos do governo de Cabo Verde. A análise focou mais as páginas principais dos sites abordados, buscando ocorrências a serem comparadas com as recomendações, medidas e heurísticas utilizadas para a pesquisa. O resultado da análise foi registado em tabelas e gráficos criados para cada um dos sites estudados, descrevendo problemas e acertos encontrados.
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Cabo Verde tem conhecido nos últimos anos, progressos notórios no que diz respeito ao desenvolvimento das Tecnologias de Informação e Comunicação, especialmente na área da governação electrónica e da democratização do acesso à Internet. Neste contexto, a usabilidade reveste-se de grande importância. O presente artigo analisa a usabilidade dos sites governamentais de Cabo Verde, identificando os problemas existentes e propondo medidas correctivas. Esta análise é feita recorrendo a uma amostra de 10 sites governamentais, utilizando o focusgroup e testes de usabilidade para cada um desses sites.
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The two volume record of the debates that occured during the thirty-nine days it took to draft the third constitution of the State of Iowa.
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L'objectif de cet article est d'investiguer de manière systématique la qualité des sites internet francophones traitant de la dépendance à l'alcool. Les auteurs ont examiné les 20 premières pages identifiées par trois moteurs de recherche généraux avec deux mots clés. Au total, 45 sites pertinents ont été évalués. Les auteurs concluent que la qualité globale des sites est relativement pauvre, spécialement pour la description des traitements possibles, et largement variable. La qualité de contenu n'est pas corrélée avec les autres aspects évalués tels que l'interactivité, l'esthétisme ou le dévoilement de l'identité des auteurs ou de leur source.
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Positron emission tomography with [18F] fluorodeoxyglucose (FDG-PET) plays a well-established role in assisting early detection of frontotemporal lobar degeneration (FTLD). Here, we examined the impact of intensity normalization to different reference areas on accuracy of FDG-PET to discriminate between patients with mild FTLD and healthy elderly subjects. FDG-PET was conducted at two centers using different acquisition protocols: 41 FTLD patients and 42 controls were studied at center 1, 11 FTLD patients and 13 controls were studied at center 2. All PET images were intensity normalized to the cerebellum, primary sensorimotor cortex (SMC), cerebral global mean (CGM), and a reference cluster with most preserved FDG uptake in the aforementioned patients group of center 1. Metabolic deficits in the patient group at center 1 appeared 1.5, 3.6, and 4.6 times greater in spatial extent, when tracer uptake was normalized to the reference cluster rather than to the cerebellum, SMC, and CGM, respectively. Logistic regression analyses based on normalized values from FTLD-typical regions showed that at center 1, cerebellar, SMC, CGM, and cluster normalizations differentiated patients from controls with accuracies of 86%, 76%, 75% and 90%, respectively. A similar order of effects was found at center 2. Cluster normalization leads to a significant increase of statistical power in detecting early FTLD-associated metabolic deficits. The established FTLD-specific cluster can be used to improve detection of FTLD on a single case basis at independent centers - a decisive step towards early diagnosis and prediction of FTLD syndromes enabling specific therapies in the future.
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ABSTRACT A detailed protocol for chemical clearing of bee specimens is presented. Dry specimens as well as those preserved in liquid media can be cleared using this protocol. The procedure consists of a combined use of alkaline solution (KOH or NaOH) and hydrogen peroxide (H2O2), followed by the boiling of the cleared specimens in 60–70% EtOH. Clearing is particularly useful for internal skeletal morphological research. This procedure allows for efficient study of internal projections of the exoskeleton (e.g., apodemes, furcae, phragmata, tentoria, internal ridges and sulci), but this process makes external features of the integument, as some sutures and sulci, readily available for observation as well. Upon completion of the chemical clearing process the specimens can be stored in glycerin. This procedure was developed and evaluated for the preparation of bees and other Apoidea, but modifications for use with other insect taxa should be straightforward after some experimentation on variations of timing of steps, concentration of solutions, temperatures, and the necessity of a given step. Comments on the long-term storage, morphological examination, and photodocumentation of cleared specimens are also provided.
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The Pedralta is a loggingstone formed of monzonitic leucogranites, which has a volume of about 38 m3 and weighs 101 tons. After its fall in December 1996, a public subscription was opened to meet the expenses of the restoration work, which was completed in May 1999
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Doctoral dissertation, University of Jyväskylä
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Alcohol (ethanol; EtOH) provides fuel energy to the body (29.7 kJ (7. 1 kcal)/g, 23.4 kJ (5.6 kcal)/ml), as do other macronutrients, but no associated essential nutrients. The thermogenic effect of EtOH (on average 15 % of its metabolizable value) is much greater than that of the main substrates utilized by the body, i.e. fat and carbohydrates (CHO), suggesting a lower net efficiency of energy utilization for EtOH than for fat and CHO. EtOH cannot be stored in the body and is toxic, so that there is an obligatory continuous oxidation of EtOH and it becomes the priority fuel to be metabolized. In contrast to CHO, its rate of oxidation does not depend on the dose ingested. As with CHO intake, it engenders a shift in postprandial substrate utilization (decrease in fat oxidation), but by a non-insulin-mediated mechanism. A limited amount of EtOH can be converted to fatty acids by hepatic de novo lipogenesis (as occurs with high levels of CHO feeding) from acetate production, which inhibits lipolysis in peripheral tissues. There is no evidence that EtOH consumed under normoenergetic conditions (i.e. isoenergetically replacing CHO or fat) leads to greater body fat storage than fat or CHO. However, there is still a lack of experimental studies on the influence of EtOH on the level of spontaneous physical activity in man. This effect may well depend on the dose of EtOH consumed as well as other intrinsic factors.
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BACKGROUND: Knowledge of normal heart weight ranges is important information for pathologists. Comparing the measured heart weight to reference values is one of the key elements used to determine if the heart is pathological, as heart weight increases in many cardiac pathologies. The current reference tables are old and in need of an update. AIMS: The purposes of this study are to establish new reference tables for normal heart weights in the local population and to determine the best predictive factor for normal heart weight. We also aim to provide technical support to calculate the predictive normal heart weight. METHODS: The reference values are based on retrospective analysis of adult Caucasian autopsy cases without any obvious pathology that were collected at the University Centre of Legal Medicine in Lausanne from 2007 to 2011. We selected 288 cases. The mean age was 39.2 years. There were 118 men and 170 women. Regression analyses were performed to assess the relationship of heart weight to body weight, body height, body mass index (BMI) and body surface area (BSA). RESULTS: The heart weight increased along with an increase in all the parameters studied. The mean heart weight was greater in men than in women at a similar body weight. BSA was determined to be the best predictor for normal heart weight. New reference tables for predicted heart weights are presented as a web application that enable the comparison of heart weights observed at autopsy with the reference values. CONCLUSIONS: The reference tables for heart weight and other organs should be systematically updated and adapted for the local population. Web access and smartphone applications for the predicted heart weight represent important investigational tools.
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MOTIVATION: High-throughput sequencing technologies enable the genome-wide analysis of the impact of genetic variation on molecular phenotypes at unprecedented resolution. However, although powerful, these technologies can also introduce unexpected artifacts. Results: We investigated the impact of library amplification bias on the identification of allele-specific (AS) molecular events from high-throughput sequencing data derived from chromatin immunoprecipitation assays (ChIP-seq). Putative AS DNA binding activity for RNA polymerase II was determined using ChIP-seq data derived from lymphoblastoid cell lines of two parent-daughter trios. We found that, at high-sequencing depth, many significant AS binding sites suffered from an amplification bias, as evidenced by a larger number of clonal reads representing one of the two alleles. To alleviate this bias, we devised an amplification bias detection strategy, which filters out sites with low read complexity and sites featuring a significant excess of clonal reads. This method will be useful for AS analyses involving ChIP-seq and other functional sequencing assays.
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Carbon isotope ratio (CIR) analysis has been routinely and successfully used in sports drug testing for many years to uncover the misuse of endogenous steroids. One limitation of the method is the availability of steroid preparations exhibiting CIRs equal to endogenous steroids. To overcome this problem, hydrogen isotope ratios (HIR) of endogenous urinary steroids were investigated as a potential complement; results obtained from a reference population of 67 individuals are presented herein. An established sample preparation method was modified and improved to enable separate measurements of each analyte of interest where possible. From the fraction of glucuronidated steroids; pregnanediol, 16-androstenol, 11-ketoetiocholanolone, androsterone (A), etiocholanolone (E), dehydroepiandrosterone (D), 5α- and 5β-androstanediol, testosterone and epitestosterone were included. In addition, sulfate conjugates of A, E, D, epiandrosterone and 17α- and 17β-androstenediol were considered and analyzed after acidic solvolysis. The obtained results enabled the calculation of the first reference-population-based thresholds for HIR of urinary steroids that can readily be applied to routine doping control samples. Proof-of-concept was accomplished by investigating urine specimens collected after a single oral application of testosterone-undecanoate. The HIR of most testosterone metabolites were found to be significantly influenced by the exogenous steroid beyond the established threshold values. Additionally, one regular doping control sample with an extraordinary testosterone/epitestosterone ratio of 100 without suspicious CIR was subjected to the complementary methodology of HIR analysis. The HIR data eventually provided evidence for the exogenous origin of urinary testosterone metabolites. Despite further investigations on HIR being advisable to corroborate the presented reference-population-based thresholds, the developed method proved to be a new tool supporting modern sports drug testing procedures.