Environmental influences on antibody-enhanced dengue disease outcomes

Because an enriched environment (EE) enhances T-cell activity and T-lymphocytes contribute to immunopathogenesis during heterologous dengue virus (DENV) infections, we hypothesised that an EE increases dengue severity. To compare single serotype (SS) and antibody-enhanced disease (AED) infections regimens, serial intraperitoneal were performed with DENV3 (genotype III) infected brain homogenate or anti-DENV2 hyperimmune serum followed 24 h later by DENV3 (genotype III) infected brain homogenate. Compared AED for which significant differences were detected between the EE and impoverished environmental (IE) groups (Kaplan-Meyer log-rank test, p = 0.0025), no significant differences were detected between the SS experimental groups (Kaplan-Meyer log-rank test, p = 0.089). Survival curves from EE and IE animals infected with the AED regimen were extended after corticoid injection and this effect was greater in the EE than in the IE group (Kaplan-Meyer log-rank test, p = 0.0162). Under the AED regimen the EE group showed more intense clinical signs than the IE group. Dyspnoea, tremor, hunched posture, ruffled fur, immobility, pre-terminal paralysis, shock and death were associated with dominant T-lymphocytic hyperplasia and presence of viral antigens in the liver and lungs. We propose that the increased expansion of these memory T-cells and serotype cross-reactive antibodies facilitates the infection of these cells by DENV and that these events correlate with disease severity in an EE.

Measurement of the W-boson helicity in top-quark decays from t(t)over-bar production in lepton plus jets events in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Searches for new physics using the t(t)over-bar invariant mass distribution in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for a Higgs boson decaying into a Z and a photon in pp collisions at root s=7 and 8 TeV

A search for a Higgs boson decaying into a Z boson and a photon is described. The analysis is performed using proton-proton collision datasets recorded by the CMS detector at the LHC. Events were collected at center-of-mass energies of 7 TeV and 8 TeV, corresponding to integrated luminosities of 5.0 fb(-1) and 19.6 fb(-1), respectively. The selected events are required to have opposite-sign electron or muon pairs. No excess above standard model predictions has been found in the 120-160 GeV mass range and the first limits on the Higgs boson production cross section times the H -> Z gamma branching fraction at the LHC have been derived. The observed at 95% confidence level limits are between about 4 and 25 times the standard model cross section times the branching fraction. For a standard model Higgs boson mass of 125 GeV the expected limit at the 95% confidence level is 10 and the observed limit is 9.5. Models predicting the Higgs boson production cross section times the H -> Z gamma branching fraction to be larger than one order of magnitude of the standard model prediction are excluded for most of the 125-157 GeV mass range. (C) 2013 CERN. Published by Elsevier B.V. All rights reserved.

Jet and underlying event properties as a function of charged-particle multiplicity in proton-proton collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the differential and double-differential Drell-Yan cross sections in proton-proton collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for a new bottomonium state decaying to Upsilon(1S)pi(+)pi(-) in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Angular analysis and branching fraction measurement of the decay B-0 -> K*(0)mu(+)mu(-)

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of the prompt J/psi and psi(2S) polarizations in pp collisions at root s=7 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for top-squark pair production in the single-lepton final state in pp collisions at

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Measurement of Higgs boson production and properties in the WW decay channel with leptonic final states

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Search for the standard model Higgs boson produced in association with a W or a Z boson and decaying to bottom quarks

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Measurement of the t(t)over-bar production cross section in the dilepton channel in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Studies of azimuthal dihadron correlations in ultra-central PbPb collisions at=2.76 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Inclusive search for a vector-like T quark with charge 2/3 in pp collisions at root s=8 TeV

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)