980 resultados para Nieuwenhuyze, Inge van
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Rede uitgespr. door ... D. M. Sluys ...
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door Henriquez Pimentel
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nagelaten diss. von Helena Popper
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samengest. door S. I. Philips
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door Jac. Zwarts
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door J. S. Da Silva Rosa
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door Jac. Zwarts
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door I. T. Philips
De kolonisatie van de Portugeesch Joodsche Natie in Suriname en de geschiedenis von de Joden Savanne
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door Fred. Oudschans Dentz
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Assays measuring platelet aggregation (thrombus formation) at arterial shear rate mostly use collagen as only platelet-adhesive surface. Here we report a multi-surface and multi-parameter flow assay to characterize thrombus formation in whole blood from healthy subjects and patients with platelet function deficiencies. A systematic comparison is made of 52 adhesive surfaces with components activating the main platelet-adhesive receptors, and of eight output parameters reflecting distinct stages of thrombus formation. Three types of thrombus formation can be identified with a predicted hierarchy of the following receptors: glycoprotein (GP)VI, C-type lectin-like receptor-2 (CLEC-2)>GPIb>α6β1, αIIbβ3>α2β1>CD36, α5β1, αvβ3. Application with patient blood reveals distinct abnormalities in thrombus formation in patients with severe combined immune deficiency, Glanzmann's thrombasthenia, Hermansky-Pudlak syndrome, May-Hegglin anomaly or grey platelet syndrome. We suggest this test may be useful for the diagnosis of patients with suspected bleeding disorders or a pro-thrombotic tendency.
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door August Rohling. Geheel herzien en verbeterd door Max. de Lamarque
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gemponeerd door A. Berlijn. De tekst bewerkt onder opzigt van G. I. Polak
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voor D. A. Lissaur