879 resultados para Next-generation sequencing


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This work deals with a red phosphor. Y3BO6:Eu3+, and its corresponding poly(N-vinylpyrrolidone) (PVP)/Y3BO6:Eu3+ luminescent composite film suitable for applications in the next generation of Hg-free lamps based on near ultraviolet (UV) light emitting diodes (LEDs). Well crystallized samples of Y3BO6 powders with the Eu3+ content up to 20 mol% were prepared by the Pechini method. After structural, morphological and optical characterization, the best doping rate of Eu3+ in the matrix was determined to be 15 mol%. This optimal powder, which is highly friable, was easily ground into fine particles and homogeneously dispersed into a PVP polymer solution to give rise to a polymer phosphor composite. Structural and optical features of the composite film have been studied and compared to those of a pristine PVP film and Y3BO6:Eu3+ powder. All the characterization (XRD, SAXS, luminescence...) proved that the red phosphor particles are well incorporated into the polymer composite film which exhibited the characteristic red emission of Eu3+ under UV light excitation. Furthermore, photostability of the polymer/phosphor composite film under UV-LED irradiation was evaluated from exposure to accelerated artificial photoageing at wavelengths above 300 nm.

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The weight of a vehicle has always been considered an extreme important factor, because it interferes in the performance, steering, consume, environmental impact, wear of components, among the others. Because of the new demand, consume reduction aim and gases emission increased the necessity to manufacture lighter vehicles, guaranteeing the complying with the gas emission international law. Besides the legal demand, the low weight will certainly be essential for the competitiveness for the next generation of vehicles. It is with this thinking the composite materials have been introduced in the automobilist industry, because those materials show an excellent relation of strength/weight, providing a reduction of consume and the increase of load capacity. Those factors justify the increase of interest of industry and the necessity of optimization of those materials and of their process. For this research, the field of application will be the Baja SAE Project, a project that is fully developed by engineering students, where they build a prototype single seat, off-road category, for use on hilly slopes with obstacle. This research aims to study two key components of the prototype are made of composite materials, analyzing all the processing. In addition, there is the analysis of the viability of this production parts to a Baja SAE vehicle, in order to increase their performance and reduce their weight without reducing the safety and robustness of the prototype. It was possible to achieve weight reduction of the steering subsystem with manufacturing the flywheel hybrid composite (carbon/glass) and the replacement of SAE 1010 steel by hybrid composite (carbon/aramid) in CVT box. The importance of this study is to obtain a good project for the vehicle of technical and scientific manner, contributing to the know-how to the team and providing a basis for optimization for upcoming projects

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Assuming that neutrinos are Majorana particles, in a three-generation framework, current and future neutrino oscillation experiments can determine six out of the nine parameters which fully describe the structure of the neutrino mass matrix. We try to clarify the interplay among the remaining parameters, the absolute neutrino mass scale and two CP violating Majorana phases, and how they can be accessed by future neutrinoless double beta (0vυββ) decay experiments, for the normal as well as for the inverted order of the neutrino mass spectrum. Assuming the oscillation parameters to be in the range presently allowed by atmospheric, solar, reactor, and accelerator neutrino experiments, we quantitatively estimate the bounds on m 0, the lightest neutrino mass, that can be inferred if the next generation 0υββ decay experiments can probe the effective Majorana mass (m ee) down to ∼1 meV. In this context we conclude that in the case that neutrinos are Majorana particles, (a) if m 0≳300 meV, i.e., within the range directly attainable by future laboratory experiments as well as astrophysical observations, then m ee≳30 meV must be observed, (b) if m 0 ≤ 300 meV, results from future 0υββ decay experiments combined with stringent bounds on the neutrino oscillation parameters, especially the solar ones, will place much stronger limits on the allowed values of m 0 than these direct experiments. For instance, if a positive signal is observed around m ee = 10 meV, we estimate 3≲m 0/meV≲65 at 95% C.L.; on the other hand, if no signal is observed down to m ee = 10 meV, then m 0≲55 meV at 95% C.L.

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We study the production of gauge-boson pairs at the next generation of linear e+e- colliders operating in the eγ mode. The processes eγ → VV′F (V,V′ = W,Z, or γ and F = e or ν) can give valuable information on possible deviations of the quartic vector-boson couplings from the Standard Model predictions. We establish the range of the new couplings that can be explored in these colliders based on a 3σ effect in the total cross section. We also present several kinematical distributions of the final state particles that could manifest the underlying new dynamics. Our results show that an eγ collider can extend considerably the bounds on anomalous interactions coming from oblique radiative corrections and from direct searches in e+e- colliders.

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We analyze the capability of the next generation of linear electron-positron colliders to unravel the spin and couplings of excited leptons predicted by composite models. Assuming that these machines will be able to operate both in the e+e- and e-γ modes, we study the effects of the excited electrons of spin 1/2 and 3/2 in the reactions e-γ → e-γ and e+e- → γγ. We show how the use of polarized beams is able not only to increase the reach of these machines, but also to determine the spin and couplings of the excited states.

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We evaluate the potential for searching for isosinglet neutral heavy leptons (N), such as right-handed neutrinos, in the next generation of e+e- linear colliders, paying special attention to contributions from the reaction γe→WN initiated by photons from beamstrahlung and laser back-scattering. We find that these mechanisms are both competitive and complementary to the standard e+e-→vN annihilation process for producing neutral heavy leptons in these machines and greatly extends the search range over HERA and LEP200.

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A complete analysis of the sensitivity to new Hbb̄ couplings from the process e+e- → bb̄vv̄ at the next generation of linear colliders was performed. These new couplings were predicted by many extensions of the Standard Model. The results are comparable to the study performed previously where a global fit analysis for L=500 fb-1 and √s=500 GeV resulted in a relative accuracy of 2.2% in the gHbb Yukawa coupling.

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Pós-graduação em Ciência da Computação - IBILCE

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Pós-graduação em Patologia - FMB

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The next-generation SONET metro network is evolving into a service-rich infrastructure. At the edge of such a network, multi-service provisioning platforms (MSPPs) provide efficient data mapping enabled by Generic Framing Procedure (GFP) and Virtual Concatenation (VC). The core of the network tends to be a meshed architecture equipped with Multi-Service Switches (MSSs). In the context of these emerging technologies, we propose a load-balancing spare capacity reallocation approach to improve network utilization in the next-generation SONET metro networks. Using our approach, carriers can postpone network upgrades, resulting in increased revenue with reduced capital expenditures (CAPEX). For the first time, we consider the spare capacity reallocation problem from a capacity upgrade and network planning perspective. Our approach can operate in the context of shared-path protection (with backup multiplexing) because it reallocates spare capacity without disrupting working services. Unlike previous spare capacity reallocation approaches which aim at minimizing total spare capacity, our load-balancing approach minimizes the network load vector (NLV), which is a novel metric that reflects the network load distribution. Because NLV takes into consideration both uniform and non-uniform link capacity distribution, our approach can benefit both uniform and non-uniform networks. We develop a greedy loadbalancing spare capacity reallocation (GLB-SCR) heuristic algorithm to implement this approach. Our experimental results show that GLB-SCR outperforms a previously proposed algorithm (SSR) in terms of established connection capacity and total network capacity in both uniform and non-uniform networks.

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Wavelength-routed networks (WRN) are very promising candidates for next-generation Internet and telecommunication backbones. In such a network, optical-layer protection is of paramount importance due to the risk of losing large amounts of data under a failure. To protect the network against this risk, service providers usually provide a pair of risk-independent working and protection paths for each optical connection. However, the investment made for the optical-layer protection increases network cost. To reduce the capital expenditure, service providers need to efficiently utilize their network resources. Among all the existing approaches, shared-path protection has proven to be practical and cost-efficient [1]. In shared-path protection, several protection paths can share a wavelength on a fiber link if their working paths are risk-independent. In real-world networks, provisioning is usually implemented without the knowledge of future network resource utilization status. As the network changes with the addition and deletion of connections, the network utilization will become sub-optimal. Reconfiguration, which is referred to as the method of re-provisioning the existing connections, is an attractive solution to fill in the gap between the current network utilization and its optimal value [2]. In this paper, we propose a new shared-protection-path reconfiguration approach. Unlike some of previous reconfiguration approaches that alter the working paths, our approach only changes protection paths, and hence does not interfere with the ongoing services on the working paths, and is therefore risk-free. Previous studies have verified the benefits arising from the reconfiguration of existing connections [2] [3] [4]. Most of them are aimed at minimizing the total used wavelength-links or ports. However, this objective does not directly relate to cost saving because minimizing the total network resource consumption does not necessarily maximize the capability of accommodating future connections. As a result, service providers may still need to pay for early network upgrades. Alternatively, our proposed shared-protection-path reconfiguration approach is based on a load-balancing objective, which minimizes the network load distribution vector (LDV, see Section 2). This new objective is designed to postpone network upgrades, thus bringing extra cost savings to service providers. In other words, by using the new objective, service providers can establish as many connections as possible before network upgrades, resulting in increased revenue. We develop a heuristic load-balancing (LB) reconfiguration approach based on this new objective and compare its performance with an approach previously introduced in [2] and [4], whose objective is minimizing the total network resource consumption.

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Lightpath scheduling is an important capability in next-generation wavelength-division multiplexing (WDM) optical networks to reserve resources in advance for a specified time period while provisioning end-to-end lightpaths. In a dynamic environment, the end user requests for dynamic scheduled lightpath demands (D-SLDs) need to be serviced without the knowledge of future requests. Even though the starting time of the request may be hours or days from the current time, the end-user however expects a quick response as to whether the request could be satisfied. We propose a two-phase approach to dynamically schedule and provision D-SLDs. In the first phase, termed the deterministic lightpath scheduling phase, upon arrival of a lightpath request, the network control plane schedules a path with guaranteed resources so that the user can get a quick response with a deterministic lightpath schedule. In the second phase, termed the lightpath re-optimization phase, we re-provision some already scheduled lightpaths to re-optimize for improving network performance. We study two reoptimization scenarios to reallocate network resources while maintaining the existing lightpath schedules. Experimental results show that our proposed two-phase dynamic lightpath scheduling approach can greatly reduce network blocking.

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Pós-graduação em Patologia - FMB

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The time is ripe for a comprehensive mission to explore and document Earth's species. This calls for a campaign to educate and inspire the next generation of professional and citizen species explorers, investments in cyber-infrastructure and collections to meet the unique needs of the producers and consumers of taxonomic information, and the formation and coordination of a multi-institutional, international, transdisciplinary community of researchers, scholars and engineers with the shared objective of creating a comprehensive inventory of species and detailed map of the biosphere. We conclude that an ambitious goal to describe 10 million species in less than 50 years is attainable based on the strength of 250 years of progress, worldwide collections, existing experts, technological innovation and collaborative teamwork. Existing digitization projects are overcoming obstacles of the past, facilitating collaboration and mobilizing literature, data, images and specimens through cyber technologies. Charting the biosphere is enormously complex, yet necessary expertise can be found through partnerships with engineers, information scientists, sociologists, ecologists, climate scientists, conservation biologists, industrial project managers and taxon specialists, from agrostologists to zoophytologists. Benefits to society of the proposed mission would be profound, immediate and enduring, from detection of early responses of flora and fauna to climate change to opening access to evolutionary designs for solutions to countless practical problems. The impacts on the biodiversity, environmental and evolutionary sciences would be transformative, from ecosystem models calibrated in detail to comprehensive understanding of the origin and evolution of life over its 3.8 billion year history. The resultant cyber-enabled taxonomy, or cybertaxonomy, would open access to biodiversity data to developing nations, assure access to reliable data about species, and change how scientists and citizens alike access, use and think about biological diversity information.