A connection between extracellular matrix and hormonal signals during the development of the human fetal adrenal gland

The human adrenal cortex, involved in adaptive responses to stress, body homeostasis and secondary sexual characters, emerges from a tightly regulated development of a zone-specific secretion pattern during fetal life. Its development during fetal life is critical for the well being of pregnancy, the initiation of delivery, and even for an adequate adaptation to extra-uterine life. As early as from the sixth week of pregnancy, the fetal adrenal gland is characterized by a highly proliferative zone at the periphery, a concentric migration accompanied by cell differentiation (cortisol secretion) and apoptosis in the central androgen-secreting fetal zone. After birth, a strong reorganization occurs in the adrenal gland so that it better fulfills the newborn's needs, with aldosterone production in the external zona glomerulosa, cortisol secretion in the zona fasciculata and androgens in the central zona reticularis. In addition to the major hormonal stimuli provided by angiotensin II and adrenocorticotropin, we have tested for some years the hypotheses that such plasticity may be under the control of the extracellular matrix. A growing number of data have been harvested during the last years, in particular about extracellular matrix expression and its putative role in the development of the human adrenal cortex. Laminin, collagen and fibronectin have been shown to play important roles not only in the plasticity of the adrenal cortex, but also in cell responsiveness to hormones, thus clarifying some of the unexplained observations that used to feed controversies.

Generalization of temporal order detection skill learning: two experimental studies of children with dyslexia

The objective of this study was to investigate the phenomenon of learning generalization of a specific skill of auditory temporal processing (temporal order detection) in children with dyslexia. The frequency order discrimination task was applied to children with dyslexia and its effect after training was analyzed in the same trained task and in a different task (duration order discrimination) involving the temporal order discrimination too. During study 1, one group of subjects with dyslexia (N = 12; mean age = 10.9 ± 1.4 years) was trained and compared to a group of untrained dyslexic children (N = 28; mean age = 10.4 ± 2.1 years). In study 2, the performance of a trained dyslexic group (N = 18; mean age = 10.1 ± 2.1 years) was compared at three different times: 2 months before training, at the beginning of training, and at the end of training. Training was carried out for 2 months using a computer program responsible for training frequency ordering skill. In study 1, the trained group showed significant improvement after training only for frequency ordering task compared to the untrained group (P < 0.001). In study 2, the children showed improvement in the last interval in both frequency ordering (P < 0.001) and duration ordering (P = 0.01) tasks. These results showed differences regarding the presence of learning generalization of temporal order detection, since there was generalization of learning in only one of the studies. The presence of methodological differences between the studies, as well as the relationship between trained task and evaluated tasks, are discussed.

Heidegger and Blumenberg on modernity

The debate surrounding the way in which Heidegger and Blumenberg understand the modern age is an opportunity to discuss two different approaches to history. On one hand, from Heidegger's perspective, history should be understood as starting from how Western thought related to Being, which, in metaphysical thinking, took the form of the forgetfulness of Being. Thus, the modern age represents the last stage in the process of forgetfulness of Being, which announces the moment of the rethinking of the relationship with Being by appealing to the authentic disclosure of Being. On the other hand, Blumenberg understands history as the result of the reoccupation process, which means replacing old theories with other new ones. Thus, to the historical approach it is not important to identify epochs as periods of time between two events, but to think about the discontinuities occurring throughout history. Starting from here, the modern age will be thought of not as an expression of the radicalization of the forgetfulness of Being, but as a response to the crises of medieval conceptions. For the same reason, the interpretation of history as a history of the forgetfulness of Being is considered by Blumenberg to subordinate history to an absolute principle, without taking into account its protagonists' needs and necessities.

Loistehon kompensoinnin ja yliaaltosuodattimien nykytila sekä kehityskohteet Kemira Chemicals Oy:n Joutsenon tehtaalla

Tutkimuksessa käsitelty kemikaalitehdas on 110 kV:n kantaverkkoon liittyvä tehointensiivinen teollisuuslaitos. Prosessien käyttöön mukautetut sähkönjakeluverkon yliaaltosuodattimet ja niiden käyttökytkennät ovat tärkeässä asemassa loistehon tuoton hallitsemiseksi liittymän loistehoikkunaan ja riittävän yliaaltosuodatuksen järjestämiseksi häviöt minimoiden. Kohteena olleen kemikaalitehtaan sähkönjakeluverkon kompensointia ja yliaaltosuodatusta on viimeksi tutkittu vuonna 2003. Tämän jälkeen verkostokomponentit ovat ikääntyneet, prosessien käyttö sekä pienjänniteverkko ovat muuttuneet ja tehdasta käyttävät osittain eri henkilöt. Nykytilaselvitykselle ja verkon kehityskohteiden analysoinnille on tullut tarve edellisen selvityksen jatkoksi. Tutkimus painottuu vahvasti kenttämittauksiin, joiden perusteella sekä kirjallisuutta ja tehtaan järjestelmiä hyödyntäen määritetään loistehotasot verkon keskeisimmissä kohteissa pien-, keski- ja suurjännitetasoilla. Tutkimuksessa esitetään lipeätehtaan suotimien uudelleenjärjestely 4. yliaallon vähentämiseksi ja yksikkökoon pienentämiseksi. Kantaverkon liittymäpisteen tilanne oli hyväksyttävä. Tutkimus esittää pienjännitekompensointia KF-4-100 keskukseen varayhteyden kapasiteettia lisäten. Tutkimus tuotti yleistietoutta verkon käytöstä ja selvitti parhaat käyttökytkennät loistehoikkunan hallitsemiseksi ilman loistehokustannuksia.

Metabolic, biochemical and molecular profiling of Catharanthus roseus flower cultivars and transformed hairy roots for monoterpenoid indole alkaloid accumulation /

Catharanthlls rosellS (L.) G Don is a commercially significant flower species and in addition is the only source of the monoterpenoid indole alkaloids (MIA) vinblastine and vincristine, which are key pharmaceutical compounds that are used to combat a number of different cancers. Therefore, procurement of the antineoplastic agents is difficult but essential procedure. Alternatively, CatharanthllS tissue cultures have been investigated as a source of these agents; however they do not produce vindoline, which is an obligate precursor to vinblastine and vincristine. The interest in developing high MIA cultivars of Catharantlws rosellS has prompted metabolic profiling studies to determine the variability of MIA accumulation of existing flowering cultivars, with particular focus on the vindoline component ofthe pathway. Metabolic profiling studies that used high performance liquid chromatography of MIAs from seedlings and young leaf extracts from 50 different flowering cultivars showed that, except for a single low vindoline cultivar (Vinca Mediterranean DP Orchid), they all accumulate similar levels of MIAs. Further enzymatic studies with extracts from young leaves and from developing seedlings showed that the low vindoline cultivar has a IO-fold lower tabersonine-16-hydroxylase activity than those of CatharanthllS rosellS cv Little Delicata. Additionally, studies aimed at metabolic engineering ofvindoline bios}l1thesis in Catharanthus rosellS hairy root cultures have been performed by expressing the last step in vindoline biosynthesis [Dcacetylvindoline-4-0- acetyltransferase (DAT)]. Enzymatic profiling studies with transformed hairy roots have confirmed that over-expressing DAT leads to lines with high levels of O-acetyltransferase activity when compared to non-expressing hairy roots. One particular DA T over111 expressing hairy root culture (line 7) contained 200 times the OAT activity than leaves of control lines. Additional MIA analyses revealed that DAT over-expressing hairy roots have an altered alkaloid profile with significant variation in the accumulation of h6rhammericine. Further analysis of transformed hairy root line 7 suggests a correlation between the expression of OAT activity and h6rhammericine accumulation with root maturation. These studies show that metabolic and selective enzymatic profiling can enhance our ability to search for relevant MIA pathway mutants and that genetic engineering with appropriate pathway genes shows promise as a tool to modify the MIA profile of Catharanthus roseus.

The effect of feeding regime on larval black fly (Diptera: simuliidae) primary head fan ray number

Identification of larval simuliids has always been difficult due to the morphological similarity many species bear to one another. For this reason all characters available have been drawn upon to aid in species identification, including head fan ray number. Even in light of an increasing body of anecdotal reports that head fan ray number is not fixed, it has continued to be used to aid species identification. In the current experiment simuliid larvae were reared under controlled laboratory conditions to last instar in one of three feeding regimes. Out of nine trials, the results of six showed a significant inverse relationship between feeding regime and head fan ray number. In addition to the laboratory experiments, larvae were also collected from the field over the course of the spring and summer, 1994. From these samples significant interspecific and intraspecific variations in head fan ray number were found both spatially and temporally within Algonquin Park. From these data it is concluded that head fan ray number for the species analysed is a developmentally plastic character, which varies in response to food availability. Furthermore, given the extreme variations in head fan ray number found in some species, I recommend that head fan ray number not be used as an aid to identification unless it can be shown to be a fixed character for the species in question.

John Adams Smith letter, Jan. 14, 1813

Transcript: New York Jan. 14. 1813. My dear uncle, I had nearly concluded to have made my [jaunt?] earlier than I had mentioned in my last letter to you, for Swartout had intended to have written by me to Father & yourself; having [Louisa?] concluded not so soon to depart he sends me his letters which I forward in mail, I shall hope to have letters from home soon, it is a great pleasure to hear from any of you. I said last week in Hollands letter mentioning [bladeworth?] account, I have explained to him. It is a mistake about me agreeing to pay Mr. [Dening?] [their?] account. Caroline mentions to me your jaunt to [Sophia?], but I regret our friend there should be unpleasantly situated. I have not yet seen Col. Willett but will see him as mentioned. I have neglected to go there for some time which has been remiss in me. We have nothing new I believe unless it be that Armstrong & Jones of Philadelphia have been nominated as Secretarys of War & the Navy & [cer?] this in all probability may be appointed. There may be room for speculation, but perhaps it is not probable that Canada will be ceded to American Valor in the year 1813. There is a Bill before congress by which it may be made penal to enter on board American vessels, either British subjects or naturalized Americans, which it is presoomed by many will [spon?] the accommodation of Peace – may be yes may be no – the proof of the pudding is in the eating of it. I imagine pacification is not so near at hand although it is much to be desired. Whatever might be for the honor & prosperity of the Country I would strenuously advocate, aloof from partial & party considerations. We have not a word as yet what the Council at Albany may be thinking of as yet. I suppose these things will come in time, perhaps untimely to many. I desire for the present not to be found among the untimely. I am your sincerely, with love to all. John Adams Smith

Letter - Andrew Cowan to William Cowan

A letter from Andrew Cowan to his son William Cowan 29 Septemer 1841. The letter reads "Dear William, I have taken my pen the third time since I have received any word from you, my first letter was about the beginning of the year, and the second in the month of April with John Armstrong of Northhouse, he sailed from Liverpool the fifteen of that month with his sisters Jane and Jenny and their two children. I received a letter from him dated Cleavland in the State of Ohio the 6 of June. He did not intend stopping in that place. The leaves us all well for any thing that I know, but I have not heard from Andrew since March altho I have writen to him three months since your Mother and I are both sore faild altho we have tolerable good health for which we desire to be thankfull to the giver of all our mercies, which are new every day, that we may be found in Christs and clothed in his imputed righteousness at the last, for in him is only found true happyness. We have had another cold wet Summer and the crops is far back ------ not light, the price of -----is high and trade bad, but sheep and cattle are high. Cattle have not been higher since the French war, but the cattle trade is very bad at present and the opperatives out of imployment and consequently verrry badly of. If none of my former letters have reached you this will inform you that James is at Lanshawburn, and gets imployment all the year, he keeps a cow and five or six sheep, they have three children, Mary, Hannah, and Andrew; I was there after clipping time seeing them, they seem to be verry happy. James Lamb is well he was here the other night, he has got two letters from his son Adam this Summer; they are still in the same place and will finish their job this fall, and seem to be doing well, your Uncle Adam Scott and family are well. John was there lately there is little prospect of his getting to America as the money that was left him is not got yet and will not for some time, If ever this reach you, you must let us know how all the Scotch people that are near you, that went from this place of the Country are doing, as their freinds are anxious to hear from them, perticularly if you know what is becomed of Alexander Hoggs widow and family of ------hill, as I was desired to write to you about them - I got a letter from John Miller dated Gatt but I understand it is a long way from your place he was a gentleman and had the charge of a farm and seems verry ----- Now William if this ever reach you, you must excuse me for not filling this letter up, but if I receive an answer I promise to fill the next better, We all join in our love and respect to you and family. From your loving Father Andrew Cowan

Estelle Cuffe Hawley fonds, 1852-1999, n.d.

Estelle Cuffe Hawley (1894-1995) was an educator, businesswoman and politician, who became the first woman alderman on the St. Catharines City Council. She began her career as a teacher in Peterborough in 1913, and later taught in St. Catharines at Connaught School and St. Paul’s Ward School, where she served as Principal for six years. In 1928-29, she worked as an exchange teacher in Edmonton, Alberta. This would be Estelle’s last year in the teaching profession. She moved back to St. Catharines in 1930 and began a career in business, as an employee of Sun Life Assurance Co. She remained in this profession until around 1952. It was during this period that she became very active in the community and local politics. In 1934 she was elected to the St. Catharines Board of Education, where she advocated for the improvement of teachers’ salaries, the introduction of nursing services in schools, and the inclusion of music in the curriculum. She served as a member of the school board until 1937. The following year, she became the first woman elected to the St. Catharines City Council. As an alderman, she worked to improve the community's social welfare services, serving consecutively as chairman of all committees. She established comprehensive health services (including medical, dental and nursing), in the public, separate and secondary schools of St. Catharines, the first program of its kind in Canada. She was also instrumental in establishing minimum housing standards and engaging the public in local government by arranging a series of lectures by city officials. She remained a member of City Council until 1943. The following year she campaigned unsuccessfully for the mayoralty. In 1953 she married Hubert Hawley and moved to Orillia. She continued to remain active in the community, serving as President of the Ontario Recreation Association from 1950-1953, and editor of their Bulletin from 1955-1961. During the 1960s, she worked with various groups, including the Voice of Women, the Mental Health Association and the Freedom from Hunger Campaign. In addition to this work, Estelle wrote poetry and short stories, some of which were published in the Peterborough Review, the Globe and Mail and the Canadian Churchman. Some of her short stories (often about her childhood experiences) were broadcast on the CBC, as well as her experiences as a Town Councillor (under the pseudonym Rebecca Johnson in 1961). She also broadcast a segment that was part of a series called “Winning the Peace” in April 1944. Estelle was a sought-after public speaker, speaking on topics such as peace, democracy, citizenship, education, and women’s rights. In 1976, Brock University conferred an honorary Doctor of Law degree to Estelle for her leadership as an educator, businesswoman and a stateswoman. Her husband Hubert died that same year, and Estelle subsequently moved to Mississauga. With the assistance of an Ontario Heritage Foundation grant, she began work on her memoir. She later moved back to Orillia and died there in 1995, at the age of 101.

Letter - E.C. Schmon to Arthur A. Schmon, 7 January 1919

Eleanore Celeste is teaching at Eliot School and has five boys in detention. The children were asking questions about her engagement ring. She also mentions that the mail delivery is slow and she hasn't received Arthur's letters from the last week in October.

La Petite danseuse de quatorze ans : une analyse de la fonction subversive de l’œuvre

La Petite danseuse de quatorze ans (1881) de l’artiste français Edgar Degas (1834-1917) représente et déforme plusieurs catégories sociales et artistiques de son époque. L’œuvre peut ainsi être lue comme une mise en abyme à la fois des changements sociaux et des peurs qu’ils suscitent quant aux redéfinitions du rôle et de la place de la sculpture dans l’art et de l’art, des classes sociales, de la science et de la femme dans la société qui s’opèrent dans la seconde moitié du 19e siècle. D’une mise en contexte de l’œuvre à une analyse de la figure de la ballerine, en passant par une lecture du monde de la poupée et de la criminalité, nous chercherons à montrer comment l’œuvre offre une lecture subversive des valeurs qui sous-tendent ces catégories structurelles du Paris industriel. Ce jeu des catégories fait de la Petite danseuse une œuvre instable et ambiguë à l’image, peut-être exacerbée, de la société. La sculpture de Degas joue avec et surtout entre ces divers pôles de la société parisienne, décloisonnant ceux-ci et proposant une autre façon de comprendre la société contemporaine. Prenant ancrage dans un discours critique postmoderne, féministe et postcolonialist, le présent travail se propose ainsi de réactualiser la fonction critique de l’œuvre.

La protection des mineurs face à la cyberpédopornographie : étude comparée entre le droit criminel canadien et français

Réalisé en cotutelle avec l'Université de Paris-sud XI, France.

« Citoyennisation » et consolidation d’entités supranationales : les cas de l’Union européenne et de l’Organisation des Nations Unies

Le contexte contemporain est marqué dans la sphère politique par la multiplication des paliers de régulation. Une nouvelle structure de gestion des affaires publiques a émergé, caractérisée par la superposition, ou plutôt l’enchevêtrement, des institutions nationales, des entités infra-étatiques et des organisations supranationales (à caractère régional et international). L’État, tout en conservant un rôle privilégié, ne détient plus le monopole de la production de politiques ; la sphère nationale n’est plus le seul locus de la vie politique. De telles dynamiques de changement n’ont pas laissé inchangés les contours de la citoyenneté, élément central de la régulation du politique. Les années 90 ont ainsi vu émerger une prolifération d’analyses concernant la dimension de plus en plus post/trans/supra-nationale, voire globale, de la citoyenneté ; selon ces travaux, le locus de la citoyenneté est de moins en moins national et de plus en plus supranational. La thèse cherche à dépasser cette problématique du locus à partir d’une conception multiple et dynamique de la citoyenneté ; celle-ci est considérée comme une construction dont les contours mouvants évoluent dans le temps et l’espace. Les individus ne sont pas citoyens « par nature » ; ils le deviennent à travers un processus de « citoyennisation », au fur et à mesure que des entités politiques se constituent et se consolident. Les structures institutionnelles et les politiques publiques progressivement mises en place au sein des entités politiques supranationales créent des liens de citoyenneté avec les individus, et la nature de ces liens se transforme au fur et à mesure que les structures institutionnelles et politiques changent. C’est une analyse contextualisée de ces processus de « citoyennisation » en cours au niveau supranational que propose la thèse. Dans cette perspective, elle s’interroge sur la signification des développements récents qui ont marqué l’Union européenne et l’Organisation des Nations Unies pour la construction d’une citoyenneté supranationale. Piliers importants de la structure de régulation multi-niveaux caractérisant la sphère politique contemporaine, ces deux entités se sont ces dernières années engagées dans un processus de réformes institutionnelles profondes. En s’appuyant notamment sur les concepts de « régime de citoyenneté » et de « gouvernance » et un cadre théorique institutionnaliste, la thèse propose une analyse de l’impact des changements institutionnels en cours au sein des Nations Unies et de l’Union européenne en termes de citoyennisation.

L'intermédialité littéraire dans quelques récits d'Assia Djebar

Le parcours d’Assia Djebar est frappé du sceau de la multidisciplinarité. L’écrivaine algérienne d’expression française a en effet toujours voué un intérêt particulier à la littérature, mais également aux arts. Son engouement pour ces derniers n’a pas été sans influencer son écriture. Ce fait est a priori remarquable au niveau des nombreuses références explicites (tant intertextuelles qu’interdiscursives) que ses récits font tour à tour au cinéma, à la peinture, à la musique, à la photographie et à la mosaïque. C’est à partir de ces renvois que nous posons l’hypothèse d’une relation aux arts mise à l’œuvre de manière plus implicite dans la prose de Djebar, c’est-à-dire susceptible de définir sa poétique. Il s’agira donc pour nous de mettre au jour des procédés d’écriture qui, dans le récit djebarien, sont aptes à créer ─ moyennant leur déplacement et leur transformation ─ des effets que des techniques en usage dans d’autres arts produisent habituellement. L’intermédialité permet d’envisager ce travail : là où l’intertextualité insiste surtout sur la question des textes ; l’interdiscursivité sur celle du discours ; et l’interartialité sur celle de l’esthétique caractéristique des productions artistiques, l’intermédialité rassemble ces préoccupations en ne négligeant pas de considérer la dimension technique inhérente aux phénomènes de signification, qui prête forme à leur matière sémiotique.

Statistical potentials for evolutionary studies

Les séquences protéiques naturelles sont le résultat net de l’interaction entre les mécanismes de mutation, de sélection naturelle et de dérive stochastique au cours des temps évolutifs. Les modèles probabilistes d’évolution moléculaire qui tiennent compte de ces différents facteurs ont été substantiellement améliorés au cours des dernières années. En particulier, ont été proposés des modèles incorporant explicitement la structure des protéines et les interdépendances entre sites, ainsi que les outils statistiques pour évaluer la performance de ces modèles. Toutefois, en dépit des avancées significatives dans cette direction, seules des représentations très simplifiées de la structure protéique ont été utilisées jusqu’à présent. Dans ce contexte, le sujet général de cette thèse est la modélisation de la structure tridimensionnelle des protéines, en tenant compte des limitations pratiques imposées par l’utilisation de méthodes phylogénétiques très gourmandes en temps de calcul. Dans un premier temps, une méthode statistique générale est présentée, visant à optimiser les paramètres d’un potentiel statistique (qui est une pseudo-énergie mesurant la compatibilité séquence-structure). La forme fonctionnelle du potentiel est par la suite raffinée, en augmentant le niveau de détails dans la description structurale sans alourdir les coûts computationnels. Plusieurs éléments structuraux sont explorés : interactions entre pairs de résidus, accessibilité au solvant, conformation de la chaîne principale et flexibilité. Les potentiels sont ensuite inclus dans un modèle d’évolution et leur performance est évaluée en termes d’ajustement statistique à des données réelles, et contrastée avec des modèles d’évolution standards. Finalement, le nouveau modèle structurellement contraint ainsi obtenu est utilisé pour mieux comprendre les relations entre niveau d’expression des gènes et sélection et conservation de leur séquence protéique.