Espacio y sociedad en la ciudad contemporánea : lección inaugural del curso académico 2008-2009, 22 de septiembre de 2008

Colección: Lecciones inaugurales ; 2

"Ahuras, Daeuuas y Bagas": una revisión a la terminología religiosa del panteón iranio antiguo

Estudio sobre la evolución de la terminología religiosa utilizada por los persas durante la reforma zoroastriana

Migración y ecología trófica de peces migradores verticales dominantes del Atlántico nordeste subtropical: implicaciones en el flujo activo de carbono

[EN]Diel vertical migrants (DVMs) are mainly zooplankton and micronekton that migrate upward from 400-700 m depth every night to feed in the productive epipelagic zone and come back at dawn to the mesopelagic zone, where they release the ingested carbon. DVMs should contribute to the biological pump in the ocean and, accordingly, to thevglobal CO2 balance. A large portion of the DVMs biomass are the lanternfishes (myctophidae), which might represent a pathway accounting for a substantial export of organic carbon to the deep ocean. Nevertheless, the magnitude of this transport is still poorly known. The combined study of migration and feeding ecology is a good approach to improve our knowledge of the DVMs role in this active carbon flux. Two dominant myctophids in the Subtropical Eastern North Atlantic Ocean (Hygophum hygomii (Lütken, 1892) and (Lobianchia dofleini (Zugmayer, 1911)) were studied from several surveys carried out around the Canary Islands during the last decade. Our results showed a marked diel vertical migration and a prevailing nocturnal feeding with predation mainly on copepods and euphausiids. The digestion state of prey suggested a slow stomach evacuation rate and that most of the ingested carbon in the epipelagic is efficiently transported to the mesopelagic zone.

Albert Einstein y la revolución de la Física al inicio del Siglo XX

Esta charla se enmarca dentro de la celebración de las XX Jornadas Blascabrerianas (de homenaje a y recuerdo de Blas Cabrera Felipe

La Epigrafía de Hispania y su Historiografía en la Red: los proyectos del Centro CIL II

[ES] Por ello además de la información que ya se había alojado, y con el objetivo de dar a conocer los resultados de las distintas líneas de investigación abiertas por el CENTRO CIL iI, por una parte relativas a la Historia Antigua, la Arqueología y la Filología Latina con el estudio de sus inscripciones latinas, y, por otra a su tradición historiográfica, se decidió volcar también toda esa información en la web.

Orientación de meta ego y tarea de los atletas y entrenadores y su relación con los motivos de abandono del deporte federado : caso del sur de Brasil

Programa de doctorado: Educación física escolar: análisis, didáctica e innovación educativa

Estrategias derivadas de la teoría de juegos en un héroe literario castellano. Exégesis estratégica en la acción, el efecto y la emoción en la toma de armas del héroe. Obtención de la jerarquía de pagos en la primera parte de "El ingenioso hidalgo don Quijote de la Mancha"

Programa de Doctorado en Literatura Española y Teoría de la Literatura

Infiammazione e cancro: l'interazione COX-2/CA-IX promuove il potenziale invasivo e la sopravvivenza in ipossia delle cellule del cancro colon-rettale

Cyclooxygenase-2/Carbonic anhydrase-IX up-regulation promotes invasive potential and hypoxia survival in colorectal cancer cells Purpose: Cyclooxygenase-2 (COX-2) is a major mediator of inflammation, playing a pivotal role in colorectal carcinogenesis. Hypoxia is an universal hallmark of solid tumour in vivo. This investigation was prompted by the observation that in colorectal cancer cells the expression of COX-2 protein is positively correlated with that of the hypoxia survival gene Carbonic Anhydrase-IX (CA-IX). Experimental Design: Since COX-2 gene expression and activity is increased in hypoxia, and that CA-IX is expressed also in normoxia in colorectal cancer cells, we tested the hypothesis that COX-2 activity in normoxia, as well as in hypoxia may be functionally linked to that of CA-IX gene. We investigated the role of COX-2 and CA-IX in colorectal cancer cell lines. In this regard, we performed RNA interference to knockdown COX-2 gene in vitro and immunohistochemistry to evaluate the protein expression of COX-2 and CA-IX in human colon cancer tissue specimens ex vivo. Results: We found that COX-2, by PGE2 production, controls CA-IX gene expression in an ERK dependent manner. In line with this finding, we also showed that the COX-2 inhibition by a specific short harpin COX-2 RNA (shCOX-2) or by a specific drug (SC-236), down-regulated CA-IX expression in colon cancer cells. We then exposed colon cancer cells to hypoxia stimuli and found that COX-2/CA-IX interplay promoted hypoxia survival. Moreover, we also report that COX-2/CA-IX interplay triggers Matrix Metalloproteinase 2/9 (MMP-2/9) activation and enhances the invasiveness of colorectal cancer cells. Thus given our above observations, we found that CA-IX and COX-2 protein expressions correlate with more aggressive stage colorectal cancer tissues ex vivo. Conclusions: Taken together these data indicate that COX-2/CA-IX interplay promotes an aggressive phenotype (hypoxia survival and invasiveness) which can be modulated in vitro by COX-2 selective inhibition and which may play a role in determining the biological aggressiveness of colorectal tumours. Moreover, in vitro and ex vivo data also suggest that the signatures of inflammation (COX-2) and hypoxia (CA-IX) may be difficult to be disentangled in colon cancer, being both responsible for the up-regulation of the same pathways.