基于TOA的无线传感器网络自定位技术的研究

提出一种基于TOA(tim e of arrival)测距、利用节点之间的几何关系实现传感器网络中未知节点自定位的算法.该方法计算量小、算法简单且定位精度高.仿真实验证明了该方法的有效性.*

Learning with Deictic Representation

Most reinforcement learning methods operate on propositional representations of the world state. Such representations are often intractably large and generalize poorly. Using a deictic representation is believed to be a viable alternative: they promise generalization while allowing the use of existing reinforcement-learning methods. Yet, there are few experiments on learning with deictic representations reported in the literature. In this paper we explore the effectiveness of two forms of deictic representation and a naive propositional representation in a simple blocks-world domain. We find, empirically, that the deictic representations actually worsen performance. We conclude with a discussion of possible causes of these results and strategies for more effective learning in domains with objects.

Design thinking - a critical analysis.

The latest buzz phrase to enter the world of design research is “Design Thinking”. But is this anything new and does it really have any practical or theoretical relevance to the design world? Many sceptics believe the term has more to do with business strategy and little to do with the complex process of designing products, services and systems. Moreover, many view the term as misleading and a cheap attempt to piggyback the world of business management onto design. This paper seeks to ask is design thinking anything new? Several authors have explicitly or implicitly articulated the term “Design Thinking” before, such as Peter Rowe’s seminal book “Design Thinking” [1] first published in 1987 and Herbert Simon’s “The Sciences of the Artificial” [2] first published in 1969. In Tim Brown’s “Change by Design” [3], design thinking is thought of as a system of three overlapping spaces rather than a sequence of orderly steps namely inspiration – the problem or opportunity that motivates the search for solutions; ideation – the process of generating, developing and testing ideas; and implementation – the path that leads from the design studio, lab and factory to the market. This paper seeks to examine and critically analyse the tenets of this new design thinking manifesto set against three case studies of modern design practice. As such, the paper will compare design thinking theory with the reality of design in practice.

The potential risk from 222radon posed to archaeologists and earth scientists: reconnaissance study of radon concentrations, excavations and archaeological shelters in the Great cave of Niah, Sarawak, Malaysia

Gillmore, G. Gilbertson, D. Grattan, J. Hunt, C. McLaren, S. Pyatt, B. Banda, R. Barker, G. Denman, A. Phillips, P. Reynolds, T. The potential risk from 222radon posed to archaeologists and earth scientists: reconnaissance study of radon concentrations, excavations and archaeological shelters in the Great cave of Niah, Sarawak, Malaysia. Ecotoxicology and Environmental Safety. 2005. 60 pp 213-227.

Geochemical evidence for atmospheric pollution derived from prehistoric copper mining at Copa hill, Cwmystwyth, mid-Wales. UK

Mighall, T. Abrahams, P. Grattan, J. Hayes, D. Timberlake, S. Forsyth, S. Geochemical evidence for atmospheric pollution derived from prehistoric copper mining at Copa Hill, Cwmystwyth, mid-Wales, UK. The Science of the Total Environment. 2002. 292 pp 69-80

Worlds in Collision: Terror and the Future of Global Order

Booth, Ken, Dunne, T., Worlds in Collision: Terror and the Future of Global Order (New York: Palgrave Macmillan, 2002), pp.x+376 RAE2008

The Poetics of the Limit : Ethics and Politics in Modern and Contemporary American Poetry

Woods, Timothy, The Poetics of the Limit (New York: Palgrave Macmillan, 2003) RAE2008

A Performance Cosmology (Testimony from the Future, Evidence of the Past)

Gough, Richard, et al., A Performance Cosmology (Testimony from the Future, Evidence of the Past) (New York: Routledge, 2006), pp.xi+324 RAE2008

Antyk i współczesność: wokół pragmatyki tekstu antycznego (1Tm 1, 17). Z badań nad tradycją antyczną na Górnym Śląsku

The article presents an interpretation of the Soli Deo honor et gloria inscription from the fronton of the metropolitan cathedral of Christ the King in Katowice. The interpretation of the text depends on whether the word soli is taken as solely attributive or also as predicative. Given both the ancient and the contemporary historical and cultural contexts the former appears more plausible.

Restauração directa de classes II em pré-molares com compósitos

Tese de Doutoramento apresentada à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Doutor em em Biotecnologia e Saúde, Epidemiologia e Saúde Pública.

Making DSpace your own

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DSpace How-To Guide: Tips and tricks for managing common DSpace chores

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Identification of novel innate immune mechanisms regulating inflammation in the gastrointestinal tract

The Gastro-Intestinal (GI) tract is a unique region in the body. Our innate immune system retains a fine homeostatic balance between avoiding inappropriate inflammatory responses against the myriad commensal microbes residing in the gut while also remaining active enough to prevent invasive pathogenic attack. The intestinal epithelium represents the frontline of this interface. It has long been known to act as a physical barrier preventing the lumenal bacteria of the gastro-intestinal tract from activating an inflammatory immune response in the immune cells of the underlying mucosa. However, in recent years, an appreciation has grown surrounding the role played by the intestinal epithelium in regulating innate immune responses, both in the prevention of infection and in maintaining a homeostatic environment through modulation of innate immune signalling systems. The aim of this thesis was to identify novel innate immune mechanisms regulating inflammation in the GI tract. To achieve this aim, we chose several aspects of regulatory mechanisms utilised in this region by the innate immune system. We identified several commensal strains of bacteria expressing proteins containing signalling domains used by Pattern Recognition Receptors (PRRs) of the innate immune system. Three such bacterial proteins were studied for their potentially subversive roles in host innate immune signalling as a means of regulating homeostasis in the GI tract. We also examined differential responses to PRR activation depending on their sub-cellular localisation. This was investigated based on reports that apical Toll-Like Receptor (TLR) 9 activation resulted in abrogation of inflammatory responses mediated by other TLRs in Intestinal Epithelial Cells (IECs) such as basolateral TLR4 activation. Using the well-studied invasive intra-cellular pathogen Listeria monocytogenes as a model for infection, we also used a PRR siRNA library screening technique to identify novel PRRs used by IECs in both inhibition and activation of inflammatory responses. Many of the PRRs identified in this screen were previously believed not to be expressed in IECs. Furthermore, the same study has led to the identification of the previously uncharacterised TLR10 as a functional inflammatory receptor of IECs. Further analysis revealed a similar role in macrophages where it was shown to respond to intracellular and motile pathogens such as Gram-positive L.monocytogenes and Gram negative Salmonella typhimurium. TLR10 expression in IECs was predominantly intracellular. This is likely in order to avoid inappropriate inflammatory activation through the recognition of commensal microbial antigens on the apical cell surface of IECs. Moreover, these results have revealed a more complex network of innate immune signalling mechanisms involved in both activating and inhibiting inflammatory responses in IECs than was previously believed. This contribution to our understanding of innate immune regulation in this region has several direct and indirect benefits. The identification of several novel PRRs involved in activating and inhibiting inflammation in the GI tract may be used as novel therapeutic targets in the treatment of disease; both for inducing tolerance and reducing inflammation, or indeed, as targets for adjuvant activation in the development of oral vaccines against pathogenic attack.