Missing Persons Bulletin, June 2004

Missing Persons Bulletin provides a list of people reported to law enforcement agencies that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation.

Missing Persons Bulletin, January 2004

Missing Persons Bulletin provides a list of people reported to law enforcement agencies that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation.

Missing Persons Bulletin, February 2004

Missing Persons Bulletin provides a list of people reported to law enforcement agencies that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation.

Missing Persons Bulletin, March 2004

Missing Persons Bulletin provides a list of people reported to law enforcement agencies that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation.

Missing Persons Bulletin, April 2004

Missing Person Bulletin providing a list of those persons reported to a law enforcment agency that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation

Missing Persons Bulletin, May 2004

Missing Persons Bulletin provides a list of people reported to law enforcement agencies that are currently missing. This is the Monthly Missing Persons Bulletin published by the Iowa Missing Person Clearinghouse, Iowa Department of Public Safety, Division of Criminal Investigation.

Iowa Commission of Persons with Disabilities Commission Members And Activities, July 1, 2001—June 30, 2002

Commission members and activities for Iowa Commission for Persons with Disabilities Commission.

Division of Persons with Disabilities Agency Performance Plan

Agency Performance Plan

Iowa Division of Persons with Disabilities Annual Report, 2003

Agency Annual Report

Iowa Division of Persons with Disabilities Annual Report, 2002

Agency Annual Report

Iowa Division of Persons with Disabilities Annual Report, 2004

Annual report from Iowa Division of Persons with Disabilities

Severe hyperlipidemia causes impaired renin-angiotensin system function in apolipoprotein E deficient mice.

Dyslipidemia is a known risk factor for cardiovascular diseases and may associate with renal injury. Using mouse models with various degrees of hypercholesterolemia and hypertryliceridemia, we investigated the effects of lipids on the renin-angiotensin system (RAS). ApoE-/- mice were fed either a high fat diet (HF-ApoE-/-; mice developed hypertriglyceridemia and severe hypercholesterolemia) or regular chow (R-ApoE(-/-); mice developed less severe hypercholesterolemia only). Renal histopathology in the HF-ApoE-/- revealed massive lipid accumulation especially at the glomerular vascular pole. In these mice plasma renin concentration was significantly reduced (489+/-111 ng/(ml h) versus 1023+/-90 ng/(ml h) in R-ApoE-/- mice) and blood pressure was consequently significantly lower than in R-ApoE-/- (104+/-2 mmHg versus 115+/-2 mmHg, respectively). A model of renin-dependent renovascular hypertension (two-kidney, one clip) was generated and HF-ApoE-/- mice proved unable to increase renin secretion, and blood pressure, in response to diminished renal perfusion as compared to regular chow fed mice (665+/-90 ng/(ml h) versus 2393+/-372 ng/(ml h), respectively and 106+/-3 mmHg versus 140+/-2 mmHg, respectively). Hypertriglyceridemia and severe hypercholesterolemia are associated with renal lipid deposition and impaired renin secretion in ApoE-/- mice exposed to high fat diet. These observations further characterize the phenotype of this widely used mouse model and provide a rationale for the use of these mice to study lipid induced organ damage.

High prevalence of peripheral arterial disease in HIV-infected persons

BACKGROUND: Atherosclerosis has been assessed in human immunodeficiency virus (HIV)-infected persons by using various methods. Peripheral arterial disease (PAD) has not been evaluated, however. We studied the cross-sectional prevalence of lower limb PAD in an HIV-infected population. METHODS: PAD was assessed using the Edinburgh Claudication Questionnaire and by measuring the systolic ankle-brachial blood pressure index (ABI) at rest and after exercise. Patients with PAD were further evaluated by duplex scan of lower limb arteries. RESULTS: Ninety-two consecutive HIV-infected patients were evaluated (23.9% women; mean age, 49.5 years; 61.9% current smokers). Claudication was reported by 15.2% of the patients. PAD was found in 20.7% of the patients: 9.8% had an abnormal ABI (<0.90) at rest, and 10.9% had normal ABI at rest but a >25% decrease after exercise. Of the patients with PAD, 84.2% were investigated with duplex scan, all of whom had atherosclerotic occlusions or stenoses of the iliac or femoral arteries. Age, diabetes, smoking, and low CD4+ T lymphocyte counts were identified as independent predictors of PAD. CONCLUSIONS: The prevalence of symptomatic and asymptomatic PAD is high in the HIV-infected population and is much higher than expected (prevalence in the general population, approximately 3% at 60 years). This study suggests the presence of an epidemic of PAD approximately 20 years earlier in the HIV-infected than in the general population. Larger epidemiological studies are needed to better define risk factors and to evaluate whether PAD is associated with increased mortality, as it is in the general population.

Iowa Missing Persons 2003 Annual Report, 2003

Annual report for Missing Persons, Division of Criminal Investigation.