Contribuição das moléculas de antígeno de histocompatibilidade leucocitária (HLA) para a contratura de Dupuytren em uma população do Sudeste do Brasil

Objetivo:O objetivo deste estudo foi investigar o fenótipo do HLA em pacientes com contratura de Dupuytren (CD) para verificar a correlação desses alelos com os fatores de risco para o desenvolvimento da CD na população brasileira.Métodos:Este foi um estudo de caso-controle de 25 pacientes com CD e 443 indivíduos saudáveis sem histórico de doenças associadas ao HLA. As tipagens classe I e classe II do HLA foram feitas utilizando o método iniciador de sequências específicas da reação em cadeia da polimerase.Resultados:O fenótipo HLA-B*18 foi observado em 32% dos pacientes e 10,5% do grupo controle. Contudo, os valores de p não permaneceram significativos após correção.Discussão:Apesar de termos observado um aumento na tendência de os pacientes com CD terem o alelo HLA-B*18, os resultados não foram estatisticamente significativos após correção. Esse alelo foi maior em pacientes de etnia italiana e/ou espanhola, locais com frequências superiores a 18% e 14%, respectivamente. São necessárias investigações adicionais com uma coorte maior de pacientes com CD para confirmar o possível papel do HLA nessa doença.

Genetic diversity among volunteer donors of bone marrow in southeastern Brazil, according to the HLA system

CONTEXTO E OBJETIVO:Para a realização de transplantes de medula óssea com material alogênico, é necessária a verificação de histocompatibilidade das moléculas do sistema HLA (human leukocyte antigen), fundamental para o sucesso desses transplantes. O objetivo desta pesquisa foi caracterizar os doadores de medula óssea segundo gênero, idade, etnia e grupos HLA de um centro regional de hemoterapia brasileiro.TIPO DE ESTUDO E LOCAL:Estudo descritivo dos doadores cadastrados em um centro regional de hemoterapia de um hospital público universitário da região Sudeste do Brasil.MÉTODOS:Foram consultadas as fichas dos 66.780 doadores cadastrados entre 2005 e junho de 2011 e tabuladas as variáveis estudadas.RESULTADOS:Encontrou-se distribuição equilibrada entre os gêneros, e 82,8% dos doadores tinham até 45 anos de idade. Quanto à etnia auto-referida, 77,3% se apresentaram como brancos, 15,0% como pardos, 5,7% como negros, os 2% restantes dividindo-se em outras etnias. Quanto à caracterização imunogenética, no grupo alélico HLA-A, o mais frequente foi o HLA-A*02, com 39,20%; no grupo alélico HLA-B, o mais comum foi o HLA-B*35, com 14,18%; no grupo alélico HLA-DRB1, o mais frequente foi o HLA-DRB1*03, com 17,03% do total de doadores. Quando esses resultados são comparados com os dados do cadastro nacional de doadores (REDOME), observam-se diferenças demográficas e imunogenéticas, que se explicam pelo histórico de imigração da região de Ribeirão Preto, no Sudeste brasileiro.CONCLUSÕES:Os resultados encontrados reforçam a importância de conhecer o perfil demográfico e imunogenético das regiões do Brasil, para reduzir o tempo de espera por um doador histocompatível.

Therapeutic interventions to reduce the risk of progression from prediabetes to type 2 diabetes mellitus

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Frequencies of-308G/A (TNFA) and-509C/T (TGFB1) polymorphisms in sickle cell anemia patients from Brazil

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Identidades e diferenças: o caso da guerra civil na antiga Iugoslávia

Abstract: The civil war in the former Yugoslavia (1991 - 1995) had a strong ethnicreligious component. In an attempt to maintain the cohesion of an artificially created state post-first World War, identities were sought and accepted - and institutionalized - the differences between the various peoples that constituted the "land of the South Slavs". From the 1980s the differences were highlighted during the war and taken to the extreme, especially in the territories of Croatia and BosniaHerzegovina. From literature and the author's personal experience and using concepts of culture, ethnicity, identity, difference, belonging, nation and state, the text shows how the ethnic-religious differences were used during the civil war in Yugoslavia to claim possession of territories, strengthen discourse of the impossibility of coexistence, overvalue potential threats and fear and justify the perpetration of crimes against humanity.

Dialética da diferença

The present article aims to discuss the theme of dialectical difference according to the concepts of critical theory. At first, the issue of the difference will be thinking about their negative reception that the production of stereotypes and prejudices on ethnicity, race and gender. In a second step, the subject will be treated on its positive reception, very common among social movements and leftist academic. In a third step, both types receive the difference will be problematized from the thought of Theodor Adorno in his Negative Dialectics as possible from mediation between universality and particularity empirical conceptual.

As fronteiras: retomando a palavra e libertando significados. Quem sou eu? As mulheres e as identidades redescobertas

From one dimension of culture, the word boundary breaks away from the idea of territorial boundary defined a priori as something fixed to the delineation of boundaries. Released this commitment, it can be thought of in other dimensions: as of transition moments of identity experienced by individuals, for women, compared to established norms. Questioning the determinant and connected speech processes of change, they left the banks in which they lived and sought recognition of self, identity and new choices have taken up other possibilities for being, social inclusion, coupled with the guarantee of their rights. Recognizing the existence of this movement, I propose a look at border on the inclusion of women as widows in order to observe the multiple identities of their female protagonists. This reflection aims to take account of social fraying beyond the limits and directions in taxes and if the widow, to expand the boundaries of its meaning and consider the possibility of hybrid subjects, differentiated, and therefore mobile and moving all the time an ongoing performance of operations, as well as contemporary studies have shown about gender relations that take into account the distinctions of race, class, ethnicity, and especially for generations.

A luta pela independência na Guiné-Bissau e os caminhos do projeto educativo do PAIGC: etnicidade como problema na construção de uma identidade nacional

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Polimorfismo do gene IL6 candidato à predisposição à rotura prematura de membranas pré-termo e ao trabalho de parto pré-termo

Introduction: Preterm Labor (PTL) and Preterm Premature Rupture of Membranes (PPROM) cause severe complications for both mother and fetus. Among the risk factors associated with preterm labor and PPROM, genetic predisposition has been gaining importance. However, the association between polymorphic genes and the pathogenesis of PTL and PPROM remains elusive. A better understanding of the genetic mechanisms underlying these adverse pregnancy outcomes may enable the identification of high risk patients and allow new approaches to minimize the deleterious effects of prematurity. Aim: To determine the association between maternal IL-6 polymorphism gene and the occurrence of PTL and PPROM. Patients and Methods: The study included 109 patients with prior history of PL and/or PPROM that delivered prematurely at the Obstetrical Unit Care of Botucatu Medical School, UNESP between 2003 and 2012. The control group consisted of 68 patients that delivered at term, matched to the case group by age, ethnicity, and sex of the newborn. Oral swabs (Cath-AllTM – Epicentre Biotechnologies) were collected for analysis of genetic polymorphisms by PCR. Statistical tests were performed to compare genotype, clinical and socio-demographic data from the groups. A p-value of <0.05 was considered significant. Results: The sociodemographic characteristics in both groups were homogeneously distributed. The frequency of the polymorphic allele C, associated with less production of IL-6, and therefore thought to be protective against PTL and PPROM, was 32,5% in the study group and 30,9% in the control group, without statistically significant differences. Conclusion: Considering the sample size included in this study, the frequency of the mutated allele is similar in pregnant women who delivered at term and gestational complications as PTL and PPROM

Análise da flexibilidade e da postura em jovens atletas praticantes de futebol

there is evidence that sport can trigger the onset of postural patterns specific to each modality, regardless of the geopolitical aspects, social, cultural habits of everyday life and ethnicity. Since changes in flexibility are cited as possible precursors of decreased range of motion, thereby harming the mechanics of the lower limbs and gait. Objetcive: The objective of this study was to analyze changes in posture and flexibility in young soccer players. Methods: were assessed 51 youngsters, aged between 14 and 18 years, soccer players registered in the Municipal Presidente Prudente SP and categories of the base of Gremio of Presidente Prudente. Data were collected from the assessment by the postural software assessment, and flexibility tests the Bench, to jail and later by tests of muscle length to jail earlier proposed by Kendall et al , was also collected anthropometric data were later confronted with the results statistically. The results were organized into spreadsheets for computing, which later could be performed the statistical analysis. Values are expressed by means of central tendency and variability as well as medians and 95% confidence intervals. The comparison for each profile height and BMI was made by means of analysis of variance complemented by Tukey test. Were considered the statistical differences when P <0.05. Results: In the sample studied 64% of the subjects classified as normal posture, the same happened with 70.59% of the athletes for flexibility in relation to the center of gravity of the sample had 100% anterior displacement of the trunk and 86.28% with a deviation of center of gravity to the left, showing a tendency to some postural deviations for the group assessed. Conclusion: from the results we can conclude that there was significant relationship between the postural angle of the right leg and left angle of the pelvis with BMI and also ankle angle... (Complete abstract click electronic access below)

Práticas corporais complementares: um estudo sobre a antiginástica

The concept of physical education emerged in the XIX century through the European gymnastic methods, initially for the purpose of asserting the sovereignty of the nationality of countries, by means of exaltation of patriotism of the masses and the physical preparation for military wars. Nowadays, the cult of the ideal body has changed, becoming the unceasing desire within each society, according to its characteristics of established standards, most of the time denying the genetic determinations of each ethnicity. This social phenomenon has generated openness and encouragement to the fitness market on the rise, eager in supporting the aspirations of the cult of the body”, representing the huge seek of the idea of a healthy body and an aesthetic appearance acceptable in today's society. Parallel to this, the Body Awareness Gymnastics, also known as Technical or Complementary Practices, were introduced in Brazil in the 70s, presenting as main themes the body awareness, the mind-body relationship, and against the ideals of body training. According to authors, the pioneering technique of the movements of alternative practices in Brazil was Antiginástica of Thérèse Bertherat. Therefore, this study aims to harmonize the complementary body practices of the physical education area through literature review of published works by the author Thérèse Bertherat, entitled The body has its reasons, The body communication system, Stations of the body, The Tiger´s Den and When the body is consent. The work also includes the contribution of a particular reading of the researcher, from the experiences of the practices carried out in order to enrich the reporting work through their records, the results obtained from the experiential process

Genetic variability of inflammatory genes in the brazilian population

Inflammatory gene variants have been associated with several diseases, including cancer, diabetes, vascular diseases, neurodegenerative diseases, arthritis, and others. Therefore, determining the population genetic composition of inflammation-related genes can be useful for the determination of general risk, prognostic and therapeutic strategies to prevent or cure specific diseases. We have aimed to identify polymorphism genotype frequencies in genes related to the inflammatory response in the Brazilian population, namely, IjBL - 62AT, IjBL - 262CT, tumor necrosis factors alpha (TNFa) - 238GA, TNFa - 308GA, lymphotoxin-alpha (LTa) + 80AC, LTa + 252AG, FAS - 670AG, and FASL - 844TC, considering the white, black, and Pardo ethnicities of the Sa˜o Paulo State. Our results suggest that the Brazilian population is under a miscegenation process at the current time, since some genotypes are not in the Hardy–Weinberg equilibrium. In addition, we conclude that the Pardo ethnicity is derived from a complex mixture of ethnicities, including the native Indian population.

Envelhecimento ativo: um desafio para a equipe multidisciplinar e para as pessoas idosas frequentadoras da Unidade de Atenção ao Idoso (UAI), no município de Uberaba - MG

Pós-graduação em Serviço Social - FCHS

Relações de gênero e poder: a vivência de mulheres e homens sob o impacto da migração internacional. -

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Condição periodontal, perda dentária e diferenças socioeconômicas em adultos e idosos brasileiros

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)