Theory of compound curves in field engineering.

Reprinted from the University of Colorado studies, v.2, no.2, July 1904.

J.B. Shook's practical treatise on hog cholera, swine fever, pneumonia, and the various other diseases of swine, poultry and other live stock, with valuable information as to cause, treatment and cure, with full instructions. Showing how to compound and use the medicines for all live stock made from the receipts furnished with this book. With other valuable information.

Mode of access: Internet.

The compound eyes of Machilis.

Mode of access: Internet.

The painter and varnisher's guide, or, A treatise, both in theory and practice, on the art of making and applying varnishes, on the different kinds of painting ; and on the method of preparing colours both simple and compound ... /

Mode of access: Internet.

Cobb's explanatory arithmetick, number two : containing the compound rules, and all that is necessary of every other rule in arithmetick for practical purposes and the transactions of business ... /

Mode of access: Internet.

Cobb's explanatory arithmetick, number two : containing the compound rules and all that is necessary of every other rule in arithmetic for practical purposes ... to which is annexed a practical system of book-keeping /

Mode of access: Internet.

The painter and varnisher's guide, or, A treatise, both in theory and practice, on the art of making and applying varnishes, on the different kinds of painting, and on the method of preparing colours both simple and compound ... /

Includes index.

The Hindee story teller, or Entertaining expositor of the Roman, Persian and Nagree characters, simple and compound, in their application to the Hindoostanee language, as a written and literary vehicle.

Mode of access: Internet.

Drops of water; or, Pencillings by the sea shore, showing the mysteries of the invisible world, and the goodness of God, as seen in the wonders of creation, by the aid of the compound microscope.

pt. 1. Pencillings by the sea shore.--pt. 2. Scenery of the ocean.

A practical treatise on railway curves and location : for young engineers : containing a full description of the instruments, the manner of adjusting them, and the methods of proceeding in the field, new and simple formulae for compound and reverse curving, rules for calculating excavation and embankment, staking out work, &c., together with tables of natural sines and tangents, radii, chords, ordinates, and others of general use in the profession /

On spine: Shunk on railway curves &c.

The doctrine of compound interest : illustrated and applied to perpetual annuities, to those for terms of years certain, to life-annuities, and generally to prospective transactions, with new and compendious tables ... /

Goldsmiths'-Kress no. 24561.

A small-molecule lead compound for the treatment of Alzheimer's disease

At autopsy, Alzheimer's disease is characterised by the presence of amyloid plaques and neurofibrillary tangles, made up of two peptide sequences, amyloid-beta(1-40) (A beta 40) and amyloid-beta(1-42) (A beta 42). In Tyrode's solution (2 mM Ca2+), 10 mu M A beta 42 peptide almost immediately aggregates and eventually forms p-sheets. This aggregation can be inhibited with 4,5-dianilinophthalimide (DAPH). Ca2+-permeant AMPA receptors are involved in the neuronal Ca2+ influx (neurotoxicity) induced by the A beta 42 peptide in cultured neuronal cells. The Ca2+ influx observed with pre-incubated A beta 42 peptide was inhibited by DAPH. DAPH also inhibits epidermal growth factor receptor kinase, and this will prevent its development for use in Alzheimer's disease. The potential of DAPH as a small-molecule lead compound for the treatment of Alzheimer's disease next requires the separation of the structural requirements that reverse fibril formation and inhibit epidermal growth factor receptor kinase.

Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase

3-Fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines (14, 16, and 18-22) are highly potent and selective inhibitors of phenylethanolamine N-methyltransferase (PNMT). Molecular modeling studies with 3-fluoromethyl-7-(N-alkyl aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines, such as 16, suggested that the sulfonamide -NH-could form a hydrogen bond with the side chain of Lys57. However, SAR studies and analysis of the crystal structure of human PNMT (hPNMT) in complex with 7 indicated that the sulfonamide oxygens, and not the sulfonamide -NH-, formed favorable interactions with the enzyme. Thus, we hypothesized that replacement of the sulfonamide -NH-with a methylene group could result in compounds that would retain potency at PNMT and that would have increased lipophilicity, thus increasing the likelihood they will cross the blood brain barrier. A series of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines (23-30) were synthesized and evaluated for their PNMT inhibitory potency and affinity for the R2-adrenoceptor. A comparison of these compounds with their isosteric sulfonamides (14, 16, and 18-22) showed that the sulfones were more lipophilic but less potent than their corresponding sulfonamides. Sulfone 24 (hPNMT K-i = 1.3 mu M) is the most potent compound in this series and is quite selective for PNMT versus the R2-adrenoceptor, but 24 is less potent than the corresponding sulfonamide, 16 (hPNMT K-i = 0.13 mu M). We also report the crystal structure of hPNMT in complex with sulfonamide 15, from which a potential hydrogen bond acceptor within the hPNMT active site has been identified, the main chain carbonyl oxygen of Asn39. The interaction of this residue with the sulfonamide -NH-is likely responsible for much of the enhanced inhibitory potency of the sulfonamides versus the sulfones.