Secure and Prepared Newsletter, December 16, 2010, Vol. 6, no. 24

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Postmenopausal circulating levels of 2- and 16α-hydroxyestrone and risk of endometrial cancer.

Background:It has been suggested that the relative importance of oestrogen-metabolising pathways may affect the risk of oestrogen-dependent tumours including endometrial cancer. One hypothesis is that the 2-hydroxy pathway is protective, whereas the 16α-hydroxy pathway is harmful.Methods:We conducted a case-control study nested within three prospective cohorts to assess whether the circulating 2-hydroxyestrone : 16α-hydroxyestrone (2-OHE1 : 16α-OHE1) ratio is inversely associated with endometrial cancer risk in postmenopausal women. A total of 179 cases and 336 controls, matching cases on cohort, age and date of blood donation, were included. Levels of 2-OHE1 and 16α-OHE1 were measured using a monoclonal antibody-based enzyme assay.Results:Endometrial cancer risk increased with increasing levels of both metabolites, with odds ratios in the top tertiles of 2.4 (95% CI=1.3, 4.6; P(trend)=0.007) for 2-OHE1 and 1.9 (95% CI=1.1, 3.5; P(trend)=0.03) for 16α-OHE1 in analyses adjusting for endometrial cancer risk factors. These associations were attenuated and no longer statistically significant after further adjustment for oestrone or oestradiol levels. No significant association was observed for the 2-OHE1 : 16α-OHE1 ratio.Conclusion:Our results do not support the hypothesis that greater metabolism of oestrogen via the 2-OH pathway, relative to the 16α-OH pathway, protects against endometrial cancer.

Vendor Ranking, March 16, 2011

Vendor Ranking for letting reports from the Iowa Department of Transportation.

Agreed upon procedures report on the City of Lacona, Iowa for the period August 16, 2008 through August 31, 2010

Agreed upon procedures report on the City of Lacona, Iowa for the period August 16, 2008 through August 31, 2010

Kléber, général en chef, au Directoire exécutif. Au quartier-général du Kaire, le 25 brumaire an 8 [16 novembre 1799]

[Acte. 1799-11-16]

Lottery Action Newsletter, January 28-February 8, 2009, Vol. 16, no. 2

Lottery Newsletter for Retailers

Lottery Action Newsletter, March 9-22, 2009, Vol 16, no. 5

Lottery Newsletter for Lottery Retailers

Lottery Action Newsletter, March 23-April 5, 2009, Vol. 16, no. 8

Lottery Newsletter for Lottery Retailers