Fiscal Update, November 16, 2012

The Fiscal Division newsletter, published weekly during session and periodically during the interim.

Iowa Department of Transportation Major Items - Preliminary Quantity Report, January 16, 2013; With Addendums

Weekly letting report.

EPI Update, November 16, 2012

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

List of Bid Proposal Holders, January 16, 2013

List of Bid Proposal Holders

aIr-1, a newly found locus on mouse chromosome 16 encoding a trans-acting activator factor for MHC class II gene expression.

RJ 2.2.5 is a human B cell line that has lost the capacity to express MHC class II genes. The human class II-positive phenotype is restored in somatic cell hybrids between RJ 2.2.5 and mouse spleen cells. By karyotype and molecular studies of an informative family of hybrids we have now shown that the reexpression of human class II gene products, as well as the maintenance of the mouse class II-positive phenotype, correlates with the presence of mouse chromosome 16. Thus, the existence on this mouse chromosome of a newly found locus, designated by us aIr-1, that determines a trans-acting activator function for class II gene expression, is established. Possible implications of this finding are discussed.

Comparison of thermogenic activity induced by the new sympathomimetic Ro 16-8714 between normal and obese subjects.

In a previous study, we demonstrated that the new beta-adrenoceptor agonist Ro 16-8714 possesses thermogenic property in normal male volunteers. The aim of the present study was to compare the metabolic response of lean vs obese individuals to a similar dose of this compound. Following an overnight fast, Ro 16-8714 (0.17 mg/kg fat free mass) or a placebo was given per os to six normal-weight subjects and to six moderately obese subjects. The rate of energy expenditure (EE) and the substrate utilization were determined by indirect calorimetry (hood system) before and for 6 h following the drug administration. Heart rate and blood pressure as well as plasma glucose, insulin and free fatty acid (FFA) concentrations were also measured at regular intervals throughout the study. The increment relative to base-line (mean +/- s.e.m.) in EE was similar in the two groups and averaged 4.0 +/- 1.4 per cent and 12.2 +/- 1.4 per cent with placebo and with Ro 16-8714 respectively in lean subjects, whereas the values reached 3.5 +/- 1.2 per cent and 14.4 +/- 2.0 per cent in obese subjects. Heart rate, systolic blood pressure, insulin and FFA were increased without any significant difference between the two groups. This study shows that Ro 16-8714 is a potent thermogenic agent both in normal and obese subjects.

Iowa Department of Transportation Major Items - Preliminary Quantity Report, April 16, 2013; With Addendums

Weekly letting report.

List of Bid Proposal Holders, April 16, 2013

List of Bid Proposal Holders

Iowa Department of Transportation Major Items - Preliminary Quantity Report, July 16, 2013; With Addendums

Weekly letting report.

Report on a special investigation of the Creston Water Works for the period July 1, 2005 through November 16, 2012

Report on a special investigation of the Creston Water Works for the period July 1, 2005 through November 16, 2012

List of Bid Proposal Holders, July 16, 2013

List of Bid Proposal Holders