1000 resultados para 325.21


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Es presenta un cas d’intervenció en educació per la sostenibilitat en un centre de preescolar d’Estelí ( Nicaragua) que es duu a terme creant una Agenda 21 Escolar. El marc teòric de la investigació es recolza en l’educació per la sostenibilitat i el marc metodològic es recolza en el model d’ Agenda 21 Escolar de Barcelona, adaptant-ho a la realitat del país i del centre de preescolar concret. Els resultats destaquen: una millora de la qualitat ambiental , una promoció de nous hàbits més sensibilitzats cap al medi ambient, una millora de la participació de la comunitat educativa i una bona cohesió de l’equip docent a partir del procés de creació de l’A21 E. Seguint com a model l’ A21 E de BCN i un cop fetes les adaptacions corresponents i creades les activitats dinamitzadores l’aplicació de la A21 E en preescolars d’ Estelí és una intervenció en educació per la sostenibilitat satisfactòria .

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Weekly Newsletter from the Northwest District Office for libraries containing programs, activities, classes for the upcoming week.

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Key factors that provide context for the state's Maternal and Child Health (MCH) annual report and state plan are highlighted in this overview. This section briefly outlines Iowa's demographics, population changes, economic indicators and significant public initiatives. Major strategic planning efforts affecting development of program activities are also identified.

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Crop and livestock summaries for the state of Iowa, produced by the Iowa Department of Agriculture. Previously Agri-News

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Although approximately 50% of Down Syndrome (DS) patients have heart abnormalities, they exhibit an overprotection against cardiac abnormalities related with the connective tissue, for example a lower risk of coronary artery disease. A recent study reported a case of a person affected by DS who carried mutations in FBN1, the gene causative for a connective tissue disorder called Marfan Syndrome (MFS). The fact that the person did not have any cardiac alterations suggested compensation effects due to DS. This observation is supported by a previous DS meta-analysis at the molecular level where we have found an overall upregulation of FBN1 (which is usually downregulated in MFS). Additionally, that result was cross-validated with independent expression data from DS heart tissue. The aim of this work is to elucidate the role of FBN1 in DS and to establish a molecular link to MFS and MFS-related syndromes using a computational approach. To reach that, we conducted different analytical approaches over two DS studies (our previous meta-analysis and independent expression data from DS heart tissue) and revealed expression alterations in the FBN1 interaction network, in FBN1 co-expressed genes and FBN1-related pathways. After merging the significant results from different datasets with a Bayesian approach, we prioritized 85 genes that were able to distinguish control from DS cases. We further found evidence for several of these genes (47%), such as FBN1, DCN, and COL1A2, being dysregulated in MFS and MFS-related diseases. Consequently, we further encourage the scientific community to take into account FBN1 and its related network for the study of DS cardiovascular characteristics.

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[Documents. 1789, mars-avril]