Nasal and systemic inflammatory profile after short term smoking cessation

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Utilização de armadilha de emersão para captura de flebotomíneos em área com transmissão e sem transmissão de LVA e LTA, na região centro-oeste do estado de São Paulo, Brasil

Pós-graduação em Medicina Veterinária - FMVZ

Os registros não-convencionais da coda nasal em dados de EJA

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Repensando o lugar da representação, da transmissão e da experiência no ensino da Filosofia

The question that we develop in this study can be proposed as follows: can knowledge be transmitted in a representational way through an explanation in such a way that the one who is learning does not have an experience itself of what he is learning? Grounded on Hume, Deleuze, Rancière and Gallo, we aim to show that only the experience with the object can promote effective learning, for violating the thought to search by itself for its meaning and for its own understanding, and not for the mere repetition of contents that have been shared and taken as important, as we have seen in schools.

As grafias não-convencionais da coda silábica nasal: análise de dados de EJA

Este artigo trata das grafias não convencionais da sílaba com coda nasal encontradasem textos escritos por jovens e adultos. Para a descrição desses dados de escrita, sãoconsideradas duas complexidades: (i) a fonético-fonológica da sílaba, particularmente doelemento nasal em coda, e (ii) a da representação ortográfica da nasalidade em português.Sob o aspecto fonético, a coda corresponde a uma redução de energia, o que pode tornar ossegmentos que preenchem essa posição da sílaba menos audíveis. Sob o aspecto fonológico,a coda pode ser vista como um constituinte não imediato da sílaba cujo preenchimento sofrerestrições. Sob o aspecto ortográfico, são três as possibilidades de registro da nasalidade:, como, respectivamente, em “campo”, “canto”, “maçã”. Argumenta-se que asgrafias não convencionais analisadas podem ser motivadas pelas características fonéticofonológicasdos enunciados falados (particularmente, da sílaba com coda nasal) e, também,pelas características das convenções ortográficas dos enunciados escritos (especificamente,as convenções para representação da nasalidade da coda). Defende-se que essas grafias nãosejam vistas como erros decorrentes da interferência da fala na escrita, mas como pistas darelação constitutiva dos enunciados falados e escritos.

Desenvolvimento de uma ferramenta de otimização para avaliar a expansão da transmissão de energia

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Preparation and Characterization of Chitosan Nanoparticles for Zidovudine Nasal Delivery

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Desenvolvimento de nanopartículas de quitosana para adminstração nasal de zidovudina

Zidovudine (AZT) is the drug most commonly used in AIDS treatment, isolated or in combination with other antiretroviral agents, but it has certain limitations due to its therapeutic dose-dependent haematological toxicity. In addition, it has low oral bioavailability, since it undergoes pre-systemic metabolism. The nasal route has been used as an alternative route for drug administration, because it can promote its direct absorption to blood circulation, avoiding hepatic metabolism. However, this route presents as a factor limiting the mucociliary clearance mechanisms that remove quickly the formulation of the nasal cavity. To prolong the residence time of formulations, in this direction, has been proposed the development of mucoadhesive systems. Among the various existing systems, the use of chitosan (QS), as mucoadhesive polymer, has been widely exploited in the preparation of nanoparticles (NPs). The objective of this study was to develop and characterize QS’s NPs for intranasal administration of AZT. For both NPs have been developed by ionic crosslinking of QS with sodium tripolyphosphate (TPP). These NPs were characterized by studies of particle size distribution, zeta potential, morphology, mucoadhesion tests, assessing the ability of encapsulation of the drug and permeation profile of AZT. The evaluation of AZT in the NPs was determined by UV-Vis spectroscopy. Mucoadhesion measures were made using a texture analyzer, using a mucin disk and porcine mucous membrane , and permeation assay were conducted using porcine nasal mucous membrane adapted to the Franz cell. These results suggest that the systems in hand have great potential for nasal AZT administration

Métodos de estudo da transmissão neuromuscular

Este trabalho tem como objetivo documentar as atividades realizadas no Estágio Curricular Obrigatório do curso de Graduação em Física Médica, realizado no Laboratório de Farmacologia da Junção Neuromuscular do Departamento de Farmacologia do Instituto de Biociências da UNESP de Botucatu. O estágio englobou atividades relacionadas à Instrumentação e à Iniciação Científica, ambas visando ao estudo da Farmacologia da Transmissão Neuromuscular. Desta forma, neste relatório serão apresentados, inicialmente, uma breve revisão dos aspectos fundamentais da morfologia e da fisiologia da junção neuromuscular. Posteriormente, serão descritos os métodos de estudo da transmissão neuromuscular aprendidos no decorrer do estágio, especificamente, as técnicas miográfica, que permite o registro da contração muscular, e eletrofisiológica, que possibilita o registro de atividade elétrica celular, ambas in vitro. Finalizando, serão apresentados os resultados do Projeto de Iniciação Científica desenvolvido, cujo objetivo foi estudar a ação do extrato etanólico da planta Tabernaemontana catharinensis sobre o bloqueio neuromuscular induzido por toxinas ofídicas na preparação do nervo frênico-músculo diafragma isolado de camundongos

Estudo da transmissão esportiva na televisão brasileira

ports is an editorial present in every and any large scale news company, wheter it print, radio, television or web. However, their approach is made differently from other editorials, they have more freedom and constant use of elements that soften the text, leaving it close to entertainment. There fore, this work seeks to analyze and understand the sports broadcasting, which on the Brazilian television is usually limitate to the football. To perform the project of the conclusion of major, there was a need to study how the sport broke into television, how the sports broadcast is carried out by television media, which are the elements used for their coverage of sports events, especially football ones, and the effects that this broadcasting causes in society

Projeto mecânico do sistema de transmissão de um veículo Baja

This study aims to determine the best configuration for the new gearbox of the new Baja´s vehicle from Piratas do Vale team, focusing on the gear train, in order to achieve high performance of it. To this end, first some information about the vehicle is gathered to determine the best pair of gears configuration, then calculations about maximum bending stress, fatigue and surface thereof are performed; ; thereafter static simulations are performed using an a appropriated software. Thus this paper shows a satisfactory design of the addressed, besides providing the Baja SAE team consultation material for future use in the project

Uma análise da eficiência de uma transmissão CVT

This undergraduate thesis evaluates the effects of temperature variation of the air inside the CVT gearbox on the performance of a Continuously Variable Transmission (CVT). The CVT used in the tests was manufactured by Gaged Engineering (GX9 model) and is currently used in a Baja prototype. It’s a mechanically operated CVT, which the movement of the pulley plates varies according to the drive shaft rotation, shifting the belt along the diameter, and varying the transmission ratio. The purpose of this work is to analyze the change in the slip factor, coefficient that compares the variation between the actual transmission ratio and the ratio of geometric transmission, and its correlation with the power variation. A test bench was built and some tests were performed, indicating that was possible to achieve output power ratios of 1.75 [ℎ

Análise de falhas por fadiga de alto ciclo em eixos de transmissão utilizando o método dos elementos finitos

This work presents a study that aims to validate the fatigue analyses developed on finite element commercial software, ANSYS Workbench. It was based on mechanical tests development of traction and hardness, to verify the mechanical properties of material that the shaft was manufactured (ABNT 1045 steel), it was developed bend test, with purpose to prove the confiability degree of computational analyses, obtaining the maximum stress in a work condition determined with 40 [kgf] of load applied, and at the end, was developed the fatigue test to obtain the number of cycles that the transmission shaft can support in a work condition with 8 [kgf] of load applied. The results obtained during the work present, have to be quite satisfactory with the theoretically expected

Transmissão de potência em corrente contínua e em corrente alternada: estudo comparativo

This paper presents a comparative study based on literature and examples in the literature, the two main technologies for the transmission of electricity at high voltage: alternate current transmission and direct current transmission. Inside the direct current transmission will be shown two technologies currently employed, transmission by current source and transmission by voltage source, contributing to a better understanding of them. The ultimate goal is to provide a text for consultation to identify key characteristics that influence the choice of future transmission lines

Telemetria automotiva usando módulo de transmissão Wireless Zigbee

This paper presents a design and construct the system of data acquisition with wireless transmission of some important parameters like motor temperature, motor rotation and velocity of Unesp Racing´s formula car prototype from Universidade Estadual Paulista, Campus Guaratinguetá. This system development presents a contribution for the electrical technical features adding important points in the competition due car´s electric, in addition, enables preventive maintenance and fine adjustment of the car with the data obtained during training and racing