Síndrome urêmica em cães com doença renal crônica

Uremic syndrome, arising from kidney malfunction, consists of a set of systemic changes caused by the accumulation of toxic substances to the body. Since, with the advance of medicine, the animals lived more reaching advanced age and entering thus on track of senility, chronic renal disease, became a common complaint in the routine of the ambulatory. This high rate of morbidity generates an increased need for clarification of pathophysiology involved in this disease. The components of the uremic syndrome include water and sodium imbalance, anemia, intolerance to carbohydrate, neurological disorders, disorders of the gastrointestinal tract, osteoarthritis, immunological incompetence and metabolic acidosis. The clinical manifestations occur in isolation or in combination. In most cases canines patients are subject to an assessment when the kidney disease has evolved to the final stage with uremic syndrome and installed already, under these conditions, the prognosis is reserved

Influência da composição corporal e da síndrome metabólica sobre a relação da aptidão cardiorrespiratória com o estresse inflamatório

Physical activity is associated with lower cardiovascular disease risk factors, being cardiorespiratory fitness a major component of physical activity health related. Body fatness and sarcopenia are related to sedentary lifestyle leading to proinflammatory stress and lower cadiorespiratory capacity. This study aimed correlates C-reactive protein with cardiorespiratory fitness, analyzing the influences of anthropometrics variables and metabolic syndrome (MS) presence. the cross-sectional retrospective study included baseline data of 194 adults (62 male and 132 female), 53,74 ± 8,77 years, clinically and ethically selected for a lifestyle modification program. Total cholesterol (TC) and cholesterol lipoprotein fractions, triglycerides (TG) and glucose was dosed by dry chemistry (Vitros® system, Johnson & Johnson). Blood leukocytes was quantified by automatic cell counter (Coulter ABX®, Horiba). LDL-cholesterol was obtained by Friedwald formula. Serum ultrasensitive C-reactive protein (US-CRP) was accessed by the immunochemoluminescence method (Immulite 2000®, DPC Medlab). Weight, height, body mass index (BMI) and waist circumference (WC) were measured. Muscular mass and fat mass were obtained by bioelectrical impedance analysis (impedancemeter Quantum BIA-101Q®, Clinton Township). Arterial blood pressure was checked by auscultatory method and cardiorespiratory fitness was determined by ergoespirometric test (Balke protocol). The metabolic syndrome was diagnosed according NCEP – ATP III (2001), following recommendations of American Diabetes Association (2004). Pearson’s correlation crude and adjusted for confounders variables with p<0,05. The prevalence of MS was 30.4%. Crude correlation shows hsCRP was correlated inverse and significantly with VO2max (r= -0.21; p=-0.003) ...(Complete abstract click electronic access below)

Síndrome dilatação-vólvulo gástrico em cães

The gastric dilatation- volvulus (GDV) is an acute and potentially lethal disease, characterized by increased size of the stomach associated with mesenteric rotation on its axis, which affects mainly large breed dogs and giants with deep and narrow chest. The diagnosis is made from the history, physical examination, clinical signs and radiographic evaluation. It is an emergency that requires immediate therapy and consists on protocols to treat shock, gastric decompression, surgical repositioning of the stomach, gastropexy and intensive post-operative care. Despite the significant progress in the elucidation of pathophysiological events, risk factors and treatment, there was almost no progress in determining the root causes of this disease. A significant advance was recently described in the literature on this topic is the technique of gastropexy laparoscopy. Instruct the owners of the high risk breeds is extremely important to avoid situations in which the severity of the illness make the surgical treatment impracticable and the animal’s condition irreversible

Aspectos gerais da síndrome anorexia caquexia do câncer em pequenos animais

The cancer anorexia-cachexia syndrome is the most common paraneoplastic syndrome in Veterinary Medicine. It is characterized by severe loss of muscle mass and adipose tissue resulting in severe unintentional weight loss, anemia, fatigue, negative nitrogen balance, immune dysfuntion and other metabolic disturbances. The SAC is not only a result of inadequate intake of nutrients. The tumor requires large amounts of nutrients to allow growth and causes changes in pacient metabolism to get this energy. Recent studies suggest that the metabolic changes by cancer can be measured by hormones and cytokines produced or by the patient or the tumor, but this not completely understood. Animals with SAC have lower survival time, the greater chance of complications during treatment and lower quality of life. With the increase in the number of cancer cases in domestic animals and longer lifespan after diagnosis of malignant disease through the use of antineoplastics drugs, diagnosis and treatment of cancer anorexia-cachexia syndrome has shown great importance in that patients may have higher survival then better quality of life. This paper aims to provide information about this complex and multifunctional syndrome and its possible treatments

Utilização da ultrassonografia transcuneal como auxílio no diagnóstico da síndrome do navicular em eqüinos

The equine locomotors system alterations are very frequent and corresponds a large portion of cases in equine medicine. The most equine veterinarian’s challenge is to do a precise diagnosis of lameness cause to perform a specific and proper treatment as early as possible. The navicular syndrome is considered responsible for one third of lameness causes and, although much studied, its etiology is still not fully understood. The most varied methods of diagnosis, such as x-ray, magnetic resonance, bursography, scintigraphy, computed tomography and ultrasound, have been used to assess podotrochlear apparatus situation in order to diagnose this syndrome. Among them transcuneal ultrasound can be used to observe some important structures such as the flexor surface of distal sesamoid bone, distal deep digital flexor tendon, distal sesamoid ligament entheses odd and the distal phalanx. The aim of this present paper is provide a brief review on the use and the technique of ultrasonography on third phalanx transcuneal region evaluation and its interpretation on navicular syndrome diagnosis in horses

Antioxidantes e biomarcadores da injúria oxidativa na saliva de pacientes com síndrome de down

Vulnerability of patients with Down syndrome (DS) to oxidative stress and damage has been attributed to the overexpression of the superoxide dismutase gene, which is located in the triplicated critical region 21q22.2 of chromosome 21. The objective of this study was to investigate enzymatic and non-enzymatic antioxidant systems and levels of biomarkers of oxidative damage in saliva of patients with DS. Saliva samples were collected from 30 patients with DS and 30 controls, ranging in age from 14 to 24 years. The following parameters were analyzed: superoxide dismutase activity, concentration of malondialdehyde, carbonylated proteins, uric acid, vitamin C and total protein, peroxidase activity, and total antioxidant capacity. Patients with DS presented significantly higher superoxide dismutase activity and malondialdehyde levels than controls (p<0.05). On the other hand, no difference in carbonylated proteins or antioxidants (uric acid, vitamin C, peroxidase, and total antioxidant capacity) was observed between DS patients and controls (p>0.05). Patients with DS also presented higher salivary total protein content (p<0.05). In conclusion, despite similar antioxidant levels patients with DS are more vulnerable to oxidative stress in saliva as indicated by a significant increase in malondialdehyde concentration and superoxide dismutase activity

Acupuntura na abordagem da Síndrome da Cauda Equina em pequenos animais Trabalho

Nowadays, in any area that acts within the veterinary medicine, we talk a lot of specialists. Specialists in neurology, cardiology, dermatology, endocrinology, finally, more specialized in a subject, better is the veterinarian. However, on one hand to deepen the knowledge helped in the discovery of new diagnostics and treatments, secondly, a bit lost sight of the patient as a whole. Traditional Chinese medicine, one of whose branches is acupuncture, is aimed at exactly this approach to be fully alive, where all body is interconnected and the disease is not seen as the imbalance of one system, but, as the imbalance between our being and the environment external. Acupuncture is an alternative in the treatment of many diseases, among them Cauda Equina Syndrome, and consists of stimulating specific points on the body surface, which help the body return to its natural harmony. A Cauda Equina Syndrome is a frame subsequent to a neuromuscular spinal cord at the level of the spinal canal of the lower lumbar spine and sacral, whose treatment is almost always surgical. This study aims to show the relevance of acupuncture treatment in this condition and report the importance of the philosophy of traditional Chinese medicine nowadays, even when their arms are not in the treatment of choice

Análise multivariada de leucograma e da resposta de fase aguda em equinos acometidos por síndrome cólica de origem natural ou experimental

Pós-graduação em Medicina Veterinária - FCAV

Análise citogenética e investigação molecular do gene RASSF1A em indivíduos com síndrome mielodisplásica

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Análise de parâmetros cinéticos em mulheres com Síndrome da Dor Femoropatelar no gesto de subida de escada

Pós-graduação em Fisioterapia - FCT

Estimativa da frequência da inversão SWBinv-1 entre pais de portadores ds síndrome de Williams-Beuren e pais de filhos normais do Brasil

Pós-graduação em Ciências Biológicas (Genética) - IBB

Risco de Farmingham e evento cardiovascular em mulheres com síndrome dos ovários policísticos

Pós-graduação em Ginecologia, Obstetrícia e Mastologia - FMB

Eficácia da haptoglobina como marcador de hemólise no diagnóstico da síndrome HELLP

Introduction: The HELLP syndrome is a severe complication of pregnant women with preeclampsia (PE), characterized by association of hemolysis, changes in liver enzymes and thrombocytopenia. Hemolysis, defined by the presence of microangiopathic hemolytic anemia, is one of the characteristics in this syndrome. However, as hemolysis occurs in a short time there is some difficulty in its laboratory diagnosis. Therefore, the search for a more sensitive and specific method for hemolysis determination may help in the early diagnosis of the HELLP syndrome. Objectives: a) To determine the plasma concentration of haptoglobin in normotensive pregnant women and in pregnant women with PE, classified into mild PE, severe PE and HELLP/partial HELLP syndrome; b) To compare the efficacy of haptoglobin plasma concentration and serum total bilirubin as criteria for hemolysis diagnosis in HELLP/partial HELLP syndrome. Methods: We conducted a cross-sectional analytical and comparative study involving 66 pregnant women diagnosed with PE, being 25 cases with mild PE, 28 with severe PE, and 13 with HELLP/partial HELLP syndrome. Twenty-one normotensive pregnant women were included for comparison of haptoglobin plasma concentration between the groups and to determine the normal values for pregnant women. The variables studied were: maternal age, gestational age, systolic and diastolic blood pressure, proteinuria, hematocrit and hemoglobin values, platelet count, serum total bilirubin, lactate dehydrogenase (LDH), glutamic oxaloacetic transaminase (AST) and glutamic-pyruvic transaminase (ALT), urea, creatinine and uric acid, and also plasma concentrations of haptoglobin. The results were analyzed by nonparametric tests, with a significance level of 5%. Results: The values of urea, uric acid, AST, ALT and LDH were significantly higher, while the number of platelets was lower in pregnant women with HELLP/partial HELLP syndrome compared to pregnant women with mild PE and ...

Reabilitação oral de paciente com síndrome da combinação: relato de caso

The Combination Syndrome represents an important pathologic condition of the masticatory system that requires a complex rehabilitation treatment. The presence of flaccid mucosa is one of the most common features due to bone resorption of the pre-maxilla caused by anterior hyperfunction of the mandibular teeth on the maxillary complete denture, where the impact of oclusal loading in this region results in movement of the maxillary prosthesis into the ridge, resulting in increased resorption of the residual ridge, internal misfit and loss of the retention of the maxillary complete denture. The presence of flaccid mucosa, in such cases, leads to problems of support and stability of the maxillary complete denture, which can be treated by surgical reduction of the thickness of the tissue or using specific techniques of fabrication of prostheses. This article describes the oral rehabilitation of a patient with the Combination Syndrome where the surgical reduction of flaccid mucosa was not performed, using a modified technique of functional impression in two steps, with the objective of generating forces and less distortion in flaccid mucosa during functional impression.

Displasia ectodérmica hipohidrótica: un síndrome de interés para la odontología

Hypohidrotic ectodermal dysplasia (HED) is a rare disease of genetic etiology. The most frequent form is of recessive linked to X-chromosome inheritance with affected male and female carriers. It can occur through autosomal mutations, of the gene EDA1 gene being responsible for the majority of the cases. It is characterized by the triad: hypohidrosis, oligodontia and hypotrichosis. We present two cases of patients with HED in which we observed characteristic signs of this syndrome: delicate skin, sparce hair, eyebrows and eyelashes, periorbital wrinkles, perioral and periorbital hyperpigmentation, prominent lips, in addition the patient in case 2 also present the depressed nasal bridge. We also found decreased salivary and lacrimal secretion and maxillary hypoplasia in both cases. At the oral examination in case 1 the upper right and left deciduous canines and lower right deciduous canine were present, and in case 2 the upper and lower (right and left) deciduous canines and two upper (one right and other left) permanent incisors were present with altered morphology, all of these dental elements were healthy. The early dental treatment of patients with HED, especially in the presence of oligodontia, as observed in our cases, is important not only to provide a better quality of life for these patients in the short term, but also an attempt to minimize the changes in facial growth to which these patients are subject.