985 resultados para poly-k
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Échelle(s) : [1:1 337 000 environ], Lieues de France, de 25 au degré, 30 [= 9,8 cm]
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[Traditions. Asie. Inde. Présidence de Madras [i.e. Chennai]. Ceded Districts]
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[Traditions. Asie. Inde. Présidence de Madras [i.e. Chennai]. Etat du Kerala. Région du Malabar]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État du Kérala. Kochi]
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[Traditions. Asie. Inde. Province de Madras [i.e. Chennai]. État de Karnataka. Région du Kanara]
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[Traditions. Asie. Inde. Etat du Maharashtra. Amravati]
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[Traditions. Asie. Inde. Province du Berar. Yavatmal]
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[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]
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[Traditions. Asie. Inde. Madhya Pradesh. Maharashtra]
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[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]
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[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]
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[Traditions. Asie. Inde. Madhya Pradesh. Chhattisgarh]
Resumo:
DP1, a dimerization partner protein of the transcription factor E2F, is known to inhibit Wnt/β-catenin signalling along with E2F, although the function of DP1 itself was not well characterized. Here, we present a novel dual regulatory mechanism of Wnt/β-catenin signalling by DP1 independent from E2F. DP1 negatively regulates Wnt/β-catenin signalling by inhibiting Dvl-Axin interaction and by enhancing poly-ubiquitination of β-catenin. In contrast, DP1 positively modulates the signalling upon Wnt stimulation, via increasing cytosolic β-catenin and antagonizing the kinase activity of NLK. In Xenopus embryos, DP1 exerts both positive and negative roles in Wnt/β-catenin signalling during anteroposterior neural patterning. From subcellular localization analyses, we suggest that the dual roles of DP1 in Wnt/β-catenin signalling are endowed by differential nucleocytoplasmic localizations. We propose that these dual functions of DP1 can promote and stabilize biphasic Wnt-on and Wnt-off states in response to a gradual gradient of Wnt/β-catenin signalling to determine differential cell fates.