Antibody levels against GLURP R2, MSP1 block 2 hybrid and AS202.11 and the risk of malaria in children living in hyperendemic (Burkina Faso) and hypo-endemic (Ghana) areas.

Differences in parasite transmission intensity influence the process of acquisition of host immunity to Plasmodium falciparum malaria and ultimately, the rate of malaria related morbidity and mortality. Potential vaccines being designed to complement current intervention efforts therefore need to be evaluated against different malaria endemicity backgrounds. The associations between antibody responses to the chimeric merozoite surface protein 1 block 2 hybrid (MSP1 hybrid), glutamate-rich protein region 2 (GLURP R2) and the peptide AS202.11, and the risk of malaria were assessed in children living in malaria hyperendemic (Burkina Faso, n = 354) and hypo-endemic (Ghana, n = 209) areas. Using the same reagent lots and standardized protocols for both study sites, immunoglobulin (Ig) M, IgG and IgG sub-class levels to each antigen were measured by ELISA in plasma from the children (aged 6-72 months). Associations between antibody levels and risk of malaria were assessed using Cox regression models adjusting for covariates. There was a significant association between GLURP R2 IgG3 and reduced risk of malaria after adjusting age of children in both the Burkinabe (hazard ratio 0.82; 95 % CI 0.74-0.91, p < 0.0001) and the Ghanaian (HR 0.48; 95 % CI 0.25-0.91, p = 0.02) cohorts. MSP1 hybrid IgM was associated (HR 0.85; 95 % CI 0.73-0.98, p = 0.02) with reduced risk of malaria in Burkina Faso cohort while IgG against AS202.11 in the Ghanaian children was associated with increased risk of malaria (HR 1.29; 95 % CI 1.01-1.65, p = 0.04). These findings support further development of GLURP R2 and MSP1 block 2 hybrid, perhaps as a fusion vaccine antigen targeting malaria blood stage that can be deployed in areas of varying transmission intensity.

1.° Lex Longobardorum. — 2.° Lex Alamannorum. — 3.° Lex Bajuariorum. — 4.° Legis Longobardorum libri quatuor : accedunt glossae. — Hujusce codicis tres primae partes undecimo saeculo, altera decimo quarto videtur exarata.

Colbertinus

1.° Guillermi de Conchis philosophia in quatuor partes divisa. — 2.° Secundi, Philosophi, vita : authoris nomen non comparet.

Colbertinus

summa dictaminis, sive Magistri Petri de Vineis, Judicis magnae curiae Friderici, Imperatoris, epistolae in sex partes divisae.

Colbertinus

Observatorio de las exportaciones: Bogotá y Cundinamarca comportamiento de las exportaciones 2003-2004. Un aporte de los empresarios que se ve en todas partes. N. 7. Mayo de 2005

Gestión del conocimiento

Observatorio de las finanzas públicas de Bogotá: un aporte de los empresarios que se ve en todas partes. No. 2. Mayo de 2005

Gestión del conocimiento

Quaternary geology of the Campbellford, Trenton, Consecon, Tweed, Belleville, Wellington, Sydenham, Bath, and Yorkshire Island map-areas, Ontario /

Sediment relationships observed during geological mapping in southeastern Ontario indicate a relatively simple deglaciation history for the area during late Wisconsin time. The ice from the north (part of the Lake Simcoe lobe) and the Lake Ontario ice lobe, which were coalesced during most of late Wisconsin time, initially separated along the crest of the Oak Ridges Moraine. Available data indicate that the Oak Ridges Moraine is composed primarily of sediments pre-late Wisconsin in age capped by late Wisconsin till and interlobate deposits. Retreat of the northern ice was relatively steady and resulted in the deposition of the Dummer Moraines, a facies of the drumlinized till to the south. Retreat of the Lake Ontario ice lobe into the Lake Ontario basin was interrupted by a re-advance which covered the southeastern half of the map area. The northern ice had already retreated from the area by this time. The Lake Ontario lobe was fed through the St. Lawrence Valley, indicating that the Ottawa Valley was ice filled at this time. High level glacial lakes fronted the ice during deglaciation. These waters quickly fell to low levels as the ice retreated from the St. Lawrence Valley, opening lower outlets.

Autocuidado y calidad de vida de adultos mayores en areas urbano marginadas de Monterrey

Tesis (Maestría en Enfermería con Especialidad en Salud Comunitaria) UANL

Procesamiento y utilización de diferentes partes del cuerpo del calamar gigante Dosidicus gigas en forma de harina como factor de crecimiento en dietas balanceadas para Penaeus vannamei

Tesis (Maestría en Ciencias con Especialidad en Ecología Acuática y Pesca) U.A.N.L. Facultad de Ciencias Biológicas.

Areas de ubicación de los egresados de la carrera de Ingeniería en Sistemas Computacionales del Instituto Tecnológico de Nuevo Laredo

Tesis (Maestría en Ciencias de la Administración con Especialidad en Sistemas) U.A.N.L. Facultad de Ingeniería Mecánica y Eléctrica, 1999.

Influencia de la permeabilidad de las vías aéreas en el desarrollo facial por Dora Octavia Cantú Ríos

Tesis (Maestría en Ciencias Odontológicas con Especialidad en Ortodoncia) U.A.N.L.

El drama del alma, algo sobre México y Maximiliano, poesía en dos partes con notas en prosa y comentarios de un loco por José Zorrilla

UANL

Fotografías de la sombra : retratos en silueta de las muchas, caricaturas sociales que nos estorban el paso y nos salen al encuentro por todas partes

UANL

Siestas dogmaticas, en la que con un estilo dulce, claro y llano, por un niño es cabalmente instruido un ranchero en las cuatro partes principales de la doctrina christiana

UANL