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Title varies: Vol. II has title History of Hampton Falls, N.H.

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"This volume is in one sense a second edition of a tract which was printed in 1849, entitled 'Collections concerning the early history of the founders of a New Plymouth, the first colonists of New England'"--P. vii.

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Reprinted from the Edinburgh review.

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Ascribed to Samuel Gott by S. K. Jones (in the Library, 3d ser., no. 3, v. 1, July 1910)

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A rapid method has been developed for the quantification of the prototypic cyclotide kalata B I in water and plasma utilizing matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry. The unusual structure of the cyclotides means that they do not ionise as readily as linear peptides and as a result of their low ionisation efficiency, traditional LC/MS analyses were not able to reach the levels of detection required for the quantification of cyclotides in plasma for pharmacokinetic studies. MALDI-TOF-MS analysis showed linearity (R-2 > 0.99) in the concentration range 0.05-10 mu g/mL with a limit of detection of 0.05 mu g/mL (9 fmol) in plasma. This paper highlights the applicability of MALDI-TOF mass spectrometry for the rapid and sensitive quantification of peptides in biological samples without the need for extensive extraction procedures. (c) 2005 Elsevier B.V. All rights reserved.