Der Synagogal-Cultus in histor[isch]-kritischer Entwickelung populär dargestellt

von [David] Rothschild

Me-ḥayil el ḥayil : "from strength to strength" ; lessons for the use of Jewish children

[Verf.: Klementine Freiin von Rothschild]

Die israelitische Gemeinde Bürgel am Main

von C. Lammert

Die Judengemeinden zu Mainz, Speyer und Worms von 1349 - 1438 : ein Beitrag zur Geschichte des Mittelalters

Marburg, Univ., Diss., 1903

Me-ḥayil el ḥayil : zur Belehrung und Erbauung für Schule und Haus

[Klementine Freiin von Rothschild. Übers. von Rudolf Plaut]

Die synagogalen Gebete

[David] Rothschild

Emanzipations-Bestrebungen der jüdischen Großgemeinden des Großherzogtums Hessen im vorigen Jahrhundert : auf Grund von Protokollen und Akten des Archivs der jüd. Gemeinde Worms

von S. Rothschild

Aus der Vergangenheit der israelitischen Gemeinde zu Offenbach am Main : zur Einweihung der neuen Synagoge

hrsg. von [Siegfried] Guggenheim

Aus Vergangenheit und Gegenwart der Israelitischen Gemeinde Worms

von Samson Rothschild

Circulating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05).

OBJECTIVES Molecular subclassification of non small-cell lung cancer (NSCLC) is essential to improve clinical outcome. This study assessed the prognostic and predictive value of circulating micro-RNA (miRNA) in patients with non-squamous NSCLC enrolled in the phase II SAKK (Swiss Group for Clinical Cancer Research) trial 19/05, receiving uniform treatment with first-line bevacizumab and erlotinib followed by platinum-based chemotherapy at progression. MATERIALS AND METHODS Fifty patients with baseline and 24 h blood samples were included from SAKK 19/05. The primary study endpoint was to identify prognostic (overall survival, OS) miRNA's. Patient samples were analyzed with Agilent human miRNA 8x60K microarrays, each glass slide formatted with eight high-definition 60K arrays. Each array contained 40 probes targeting each of the 1347 miRNA. Data preprocessing included quantile normalization using robust multi-array average (RMA) algorithm. Prognostic and predictive miRNA expression profiles were identified by Spearman's rank correlation test (percentage tumor shrinkage) or log-rank testing (for time-to-event endpoints). RESULTS Data preprocessing kept 49 patients and 424 miRNA for further analysis. Ten miRNA's were significantly associated with OS, with hsa-miR-29a being the strongest prognostic marker (HR=6.44, 95%-CI 2.39-17.33). Patients with high has-miR-29a expression had a significantly lower survival at 10 months compared to patients with a low expression (54% versus 83%). Six out of the 10 miRNA's (hsa-miRN-29a, hsa-miR-542-5p, hsa-miR-502-3p, hsa-miR-376a, hsa-miR-500a, hsa-miR-424) were insensitive to perturbations according to jackknife cross-validation on their HR for OS. The respective principal component analysis (PCA) defined a meta-miRNA signature including the same 6 miRNA's, resulting in a HR of 0.66 (95%-CI 0.53-0.82). CONCLUSION Cell-free circulating miRNA-profiling successfully identified a highly prognostic 6-gene signature in patients with advanced non-squamous NSCLC. Circulating miRNA profiling should further be validated in external cohorts for the selection and monitoring of systemic treatment in patients with advanced NSCLC.

Beamte der Wormser jüdischen Gemeinde : (Mitte des 18. Jahrhunderts bis zur Gegenwart)

von S. Rothschild

Die Abgaben und die Schuldenlast der Wormser jüd. Gemeinde : 1563 - 1854

ein Beitrag zur Geschichte der jüd. Gemeinde Worms mit zwei Briefen des A. Weckerling. Von S. Rothschild