De la veritable eloquence ou Refutation des paradoxes sur l'eloquence : avancez par l'auteur de "La Connaissance de soi-même" ([Reprod.])

Collection : Archives de la linguistique française ; 176

Two component systems: physiological effect of a third component

Signal transduction systems mediate the response and adaptation of organisms to environmental changes. In prokaryotes, this signal transduction is often done through Two Component Systems (TCS). These TCS are phosphotransfer protein cascades, and in their prototypical form they are composed by a kinase that senses the environmental signals (SK) and by a response regulator (RR) that regulates the cellular response. This basic motif can be modified by the addition of a third protein that interacts either with the SK or the RR in a way that could change the dynamic response of the TCS module. In this work we aim at understanding the effect of such an additional protein (which we call ‘‘third component’’) on the functional properties of a prototypical TCS. To do so we build mathematical models of TCS with alternative designs for their interaction with that third component. These mathematical models are analyzed in order to identify the differences in dynamic behavior inherent to each design, with respect to functionally relevant properties such as sensitivity to changes in either the parameter values or the molecular concentrations, temporal responsiveness, possibility of multiple steady states, or stochastic fluctuations in the system. The differences are then correlated to the physiological requirements that impinge on the functioning of the TCS. This analysis sheds light on both, the dynamic behavior of synthetically designed TCS, and the conditions under which natural selection might favor each of the designs. We find that a third component that modulates SK activity increases the parameter space where a bistable response of the TCS module to signals is possible, if SK is monofunctional, but decreases it when the SK is bifunctional. The presence of a third component that modulates RR activity decreases the parameter space where a bistable response of the TCS module to signals is possible.

Svecia Norvegia Russia Moscovitica. 1699 - 1

Viduae 1703

Iter S. Francisci Xaverii Ex Europa in Indiã, & Iaponiam - 1

Viduae 1703

Iter S. Francisci Xaverii Ex Europa in Indiã, & Iaponiam - 3

Viduae 1703

Iter S. Francisci Xaverii Ex Europa in Indiã, & Iaponiam - 2

Viduae 1703

Evropa Orbis Christiani domina 1699 - 1

Viduae 1703

Regionvm circum polarivm Lapponiae Islandiae et Groenlandiae novae et veteris nova descriptio geographica. 1701 - 1

Viduae 1703

Repraesentatio geographica itineris maritimi navis victoriae in qva ex personis CCXXXVII finita navigatione rediere... VI Sept. Ann. MDXXII - 1

Viduae 1703

Globvs terraqvevs ecclesiastico politicvs Esinimiö. Frontispiece

Viduae 1703, Leonhard Heckenauer sculpsit

Improving the Prediction of Spontaneous and Post-thrombolytic Recanalization in Ischemic Stroke Patients.

BACKGROUND: Endovascular treatment for acute ischemic stroke patients was recently shown to improve recanalization rates and clinical outcome in a well-defined study population. Intravenous thrombolysis (IVT) alone is insufficiently effective to recanalize in certain patients or of little value in others. Accordingly, we aimed at identifying predictors of recanalization in patients treated with or without IVT. METHODS: In the observational Acute Stroke Registry and Analysis of Lausanne (ASTRAL) registry, we selected those stroke patients (1) with an arterial occlusion on computed tomography angiography (CTA) imaging, (2) who had an arterial patency assessment at 24 hours (CTA/magnetic resonance angiography/transcranial Doppler), and (3) who were treated with IVT or had no revascularization treatment. Based on 2 separate logistic regression analyses, predictors of spontaneous and post-thrombolytic recanalization were generated. RESULTS: Partial or complete recanalization was achieved in 121 of 210 (58%) thrombolyzed patients. Recanalization was associated with atrial fibrillation (odds ratio , 1.6; 95% confidence interval, 1.2-3.0) and absence of early ischemic changes on CT (1.1, 1.1-1.2) and inversely correlated with the presence of a significant extracranial (EC) stenosis or occlusion (.6, .3-.9). In nonthrombolyzed patients, partial or complete recanalization was significantly less frequent (37%, P < .01). The recanalization was independently associated with a history of hypercholesterolemia (2.6, 1.2-5.6) and the proximal site of the intracranial occlusion (2.5, 1.2-5.4), and inversely correlated with a decreased level of consciousness (.3, .1-.8), and EC (.3, .1-.6) and basilar artery pathology (.1, .0-.6). CONCLUSIONS: Various clinical findings, cardiovascular risk factors, and arterial pathology on acute CTA-based imaging are moderately associated with spontaneous and post-thrombolytic arterial recanalization at 24 hours. If confirmed in other studies, this information may influence patient selection toward the most appropriate revascularization strategy.

Claude Lefort et Cornelius Castoriadis : regards croisés sur Mai 68

Comme tous les moments révolutionnaires, Mai 68 n'est jamais complètement passé : il reste vivant pour la pensée politique contemporaine. En 1968, Cornelius Castoriadis et Claude Lefort, deux des principaux penseurs politiques de la France de l'après-guerre, proposaient leurs lectures des événements de Mai en France dans un livre important : Mai 68 : la Brèche. Pour le vingtième anniversaire des événements, ils écrivaient à nouveau sur ceux-ci, en cherchant à examiner leur postérité à la fois sociale et intellectuelle. Ces interprétations de Mai 68 font apparaître des convergences aussi bien que des oppositions théoriques entre les deux auteurs, qui concernent aussi bien le rôle de l'intellectuel que les définitions de la révolution, du pouvoir et de la démocratie. Mai 68 sert ainsi de révélateur, qui éclaire des aspects importants du dissensus politique et théorique qui a opposé Castoriadis à Lefort dès les années 1950.

Tratamientos ortopodológicos en pacientes que presentan transtornos del equilibrio estático y dinámico.

Centrándonos en la exploración del paciente que ha sufrido o sufre caídas frecuentes, presentamos unas pruebas específicas para valorar el alcance de las alteraciones que provocan pérdidas de equilibrio. Exposición de varios casos clínicos que presentan afecciones podológicas que alteran la estabilidad, y ofreceremos una alternativa de Tratamiento Ortopodológico demostrando su acción en favor del mantenimiento del equilibrio. Conclusiones referidas al diagnóstico y expectativas de Tratamientos Ortopodológicos en los pacientes ancianos.