Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats

To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and L-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of L-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis. (C) 2011 Elsevier Inc. All rights reserved.

Anabolic-androgenic steroid treatment induces behavioral disinhibition and downregulation of serotonin receptor messenger RNA in the prefrontal cortex and amygdala of male mice

Nandrolone is an anabolic-androgenic steroid (AAS) that is highly abused by individuals seeking enhanced physical strength or body appearance. Supraphysiological doses of this synthetic testosterone derivative have been associated with many physical and psychiatric adverse effects, particularly episodes of impulsiveness and overt aggressive behavior. As the neural mechanisms underlying AAS-induced behavioral disinhibition are unknown, we investigated the status of serotonergic system-related transcripts in several brain areas of mice receiving prolonged nandrolone administration. Male C57BL/6J mice received 15 mg/kg of nandrolone decanoate subcutaneously once daily for 28 days, and different sets of animals were used to investigate motor-related and emotion-related behaviors or 5-HT-related messenger RNA (mRNA) levels by real-time quantitative polymerase chain reaction. AAS-injected mice had increased body weight, were more active and displayed anxious-like behaviors in novel environments. They exhibited reduced immobility in the forced swim test, a higher probability of being aggressive and more readily attacked opponents. AAS treatment substantially reduced mRNA levels of most investigated postsynaptic 5-HT receptors in the amygdala and prefrontal cortex. Interestingly, the 5-HT(1B) mRNA level was further reduced in the hippocampus and hypothalamus. There was no alteration of 5-HT system transcript levels in the midbrain. In conclusion, high doses of AAS nandrolone in male mice recapitulate the behavioral disinhibition observed in abusers. Furthermore, these high doses downregulate 5-HT receptor mRNA levels in the amygdala and prefrontal cortex. Our combined findings suggest these areas as critical sites for AAS-induced effects and a possible role for the 5-HT(1B) receptor in the observed behavioral disinhibition.

Influência do desenvolvimento tecnológico sobre o desenvolvimento social a partir das atividades da incubadora tecnológica de Campina Grande, Campina Grande Paraíba

Este estudo avalia a influência do desenvolvimento tecnológico sobre o social, a partir das atividades produtivas desenvolvidas na unidade agroindustrial Recanto lI, no município de Catolé do Rocha, com o apoio da Incubadora Tecnológica de Campina Grande - ITCG, e o Programa de Estudos e Ações no Semi-Árido Paraibano da Universidade Federal de Campina Grande - PEASAlUFCG. Os problemas sociais no semi-árido surgiram por condições ambientais adversas e se intensificaram pela falta de políticas públicas adequadas à educação e ao desenvolvimento da região. O problema é expresso pela seguinte indagação: Qual a influência entre o desenvolvimento tecnológico e o desenvolvimento social gerados a partir da atividade produtiva da Incubadora de Campina Grande, em Campina Grande, Paraíba? A relevância deste trabalho vem da pretensão em colaborar para o estudo da relação entre desenvolvimento tecnológico e social, numa tentativa de tornar inteligível a necessidade de educação e inovação tecnológica para o desenvolvimento social, principalmente em países não desenvolvidos. Vem também da utilidade para a formulação de políticas públicas e estratégias de desenvolvimento tecnológico, identificando ações e medidas de desempenho, voltadas ao diagnóstico da contribuição das incubadoras tecnológicas para o bem-estar da sociedade. O referencial teórico foi composto pela análise da função das racionalidades dos diversos agentes sociais e de sua contribuição para as interações sociais, além da análise das realidades culturais da sociedade empresariada, do Estado e das incubadoras tecnológicas. A metodologia se utilizou da pesquisa descritiva e explicativa, de campo, documental, bibliográfica e estudo de caso. O universo foram as pessoas que compõem a ITCG e a amostra foram o diretor da Incubadora, o cientista da UFCG e o líder comunitário de Recanto lI. Os sujeitos da pesquisa confundem-se com a amostra. A coleta de dados se deu por meio da literatura sobre a temática e de inserções no campo de estudo. O tratamento de dados se utilizou da análise qualitativa do fenômeno. As principais limitações do método consistiram na coleta, no tratamento dos dados, e na utilização do estudo de caso, com possibilidade de compreensão tendenciosa do fenômeno estudado. O referencial prático apresenta o resultados da pesquisa, avaliando-os por meio da comparação com o referencial teórico estudado. Tem-se como resultados que a ITCG agiu articulando os grupos e traduzindo as realidades culturais de cada agente em prol do desenvolvimento de comunidades agroindustriais em situação de risco social, devido à problemática da seca. A ITCG atuou como alfabetizadora social ensinando aos agentes sociais os códigos culturais dos demais grupos. As desigualdades que existiam entre o cientista e o sertanejo, aprofundadas pelo vexatório histórico de escravidão do homem do campo no nordeste brasileiro, foram minimizadas pela educação dada pelo próprio cientista. A Universidade contribuiu para a redução do analfabetismo ambiental, onde o meio ambiente era tido como o principal rival do homem do sertão. O Estado, quando atua em parceria com os demais agentes sociais consegue, manter-se como o principal instrumento dos cidadãos para controlar a globalização em função de seus valores e interesses. Na ITCG o ambiente de incubação é educacional, onde os novos empreendedores são postos em contato com a realidade cultural do empresariado, do Estado e de outras comunidades da sociedade, seguindo modelos meramente educacionais. Como conclusão tem-se que a trajetória dos cidadãos de Recanto II - de escravos a exportadores - foi baseada em dois grandes tesouros, a família e areligião. O mérito da ITCG foi compreender, respeitar e preservar a realidade cultural de Recanto 11 e incentivar a interação social com outras realidades culturais capazes de gerar desenvolvimento naquela região. A saúde, o desenvolvimento infantil, a segurança, a habitação foram conquistas de Recanto 11. Como sugestão tem-se que as políticas públicas deveriam reproduzir este ambiente de desenvolvimento para todos os cidadãos brasileiros em situação de risco social, utilizando-se da família como base para interações sociais fluidas e harmônicas entre os diversos agentes sociais.

The inequality curse: constraints and political discretion

We live in an unjust world characterized by economic inequality. No liberal theory of justice is able to justify it. Inequality is not “solved” with equality of opportunity or meritocracy. Nor by the socialist and republican critique. The poor will have to count with them and with democracy to make social progress reality. In their political struggle, they will face one economic constraint: the expected profit rate must remain attractive to business investors. Yet, giving that technological progress in increasingly capital-saving, this economic constraint does not obstruct that wages grow above the productivity rate and inequality is reduced. What really is an obstacle to social justice in the rich countries is, on one hand, the power that capitalist rentiers retain and financists acquired, and, on the other, the competition originated in low wage countries.

O ensino de administração pública : histórico e diagnóstico : reflexões sobre a formação do administrador

Aprofunda a análise e a discussão no que tange à importância da melhoria da Qualidade do Ensino de Administração nas Escolas Superiores - em especial as de Formação do Administrador Público - e sua relação com a otimização dos Serviços prestados nas Instituições de Governo. Relata as vicissitudes impostas pela Coroa Portuguesa ao sistema educacional vigente à época; retrata os posteriores esforços do já então Governo da República, no sentido da criação de Escolas e Cursos Específicos de Administração e esclarece a luta politica e as incompreensões que foram vencidas para que se aceitasse a existência de um profissional de Administração no concerto das demais profissões que hoje atuam no mercado. Discorre sobre o atual processo de formação de administradores, perscruta os meandros didático-pedagógicos dos cursos hora ministrados e sugere mudanças genotípicas na condução dos misteres universitários, no que concerne à formação ética e profissional do Administrador Público, sugerindo a adoção de novos paradigmas de eficiência e eficácia nos serviços públicos. Apresenta reflexões quanto ao papel que a Universidade deverá assumir diante da comunidade científica mundial e quanto as soluções técnicas que poderão concorrer parar a instrução de um novo patamar didático-pedagógico no que respeita à utilização do saber científico na solução dos anseios sociais.

Cultural strategies: how do national cultures impact the operations strategy?

Through the assessment of the fourth round of the High Performance Manufacturing (HPM) project and the introduction of Hofstede’s Cultural Classification, the present work aims to deepen the comprehension of the impact of National Cultures on firms’ Operations Strategy. The ANOVA comparisons of four Operations Strategy elements in countries with different industrialization and development backgrounds (e.g. Germany, China, Brazil and South Korea) suggest that while Integrating Leadership and Implementation of Manufacturing Strategy are affected by the cultural levels of Power Distance, Individualism vs. Collectivism and Uncertainty Avoidance, the other two elements of Operations Strategy, Functional Integration and Formal Manufacturing Strategy, show effects of the degree of Individualism vs. Collectivism and Long-Term Orientation. The results of the study are expected to offer new perspectives on the planning and implementation of strategic and operations management for both practitioners and academics. More specifically, the analysis of cross-cultural influence over operations strategy may contribute to a better understanding of how cooperative behavior may lead firms to generate higher rents through the strengths and weaknesses of their relations, particularly in terms of global supply chains.

Apoio governamental à inovação Tecnológica: análise da indústria farmacêutica paraense

The transformations economical, cultural and social that happen in world ambit they are associated to the intense progress and expansion of new technologies, forcing governments, people, companies and nations to the introduction of new patterns of behavior, forcing, in that way, to the continuous renewal of products and technological processes to maintain the competitiveness, so much among nations, as in the managerial world. In that matter, the technological innovation is recognized as basic factor of maintainable economical competitiveness, being the responsible for the breaking and/or improvement of the techniques and production processes, what presupposes the systematization varied institutional arrangements that they involve firms, interaction nets among companies, government agencies, universities, research institutes, laboratories of companies and scientists and engineers activities. Those arrangements, to the if they articulate with the educational system, with the industrial and managerial section and, also, with the financial institutions, they take the form that Freeman (1987) it coined of national system of innovation, promoted through public politics of CT&I, which seek to induce and to support innovative initiatives in the companies, as well as to establish demands and to prioritize vocations and regional potentialities. In that context of government support to the technological innovation interferes this study, that it looked for to know the reasons of the fragility innovative in the pharmaceutical industry of State of Pará in Brazil, pointed for PINTEC (2005), starting from the point of view of the businessmen of that section. For such, the qualitative approach was used - with interviews directing semi and the technique of the content analysis. The results of the research pointed that the fragilities innovative of the section links to the ignorance of the government support to the technological innovation on the part of the businessmen of the pharmaceutical industry of State of Pará in Brazil

Gestão participativa em educação: compasso e descompasso de uma experiência de democracia no espaço escolar

This work aims at investigating the strategies of management used by State School Joaquim Jose de Medeiros, located in the city of Cruzeta - RN, as award practice of "School of Reference in Management", with a state title in 1999 at the beginning of the decade from 2000, being "Outstanding Brazil" from best management strategies nationally. In 2005, it is ranked among the best experiences of the state. It has been become complex by experiencing in that institution, but at the same time an enjoyable practice, mainly by using a social research, in a qualitative and quantitative approach, and a analysis of the institutional performance of two management practices: from 1995 to 2002 and from 2003 to 2007 . To understand the object, a investigative questionnaire was used with representatives of the school community and carried out an analysis of assessment of institutional and documents of institutional organization of the periods above in order to identify management strategies and examine the influences of the share capital, public policies , the institutional evaluation, in the process of democratic construction that has allowed achievements, highlighting Cruzeta, in the Seridó in the state of Rio Grande do Norte, semi-arid northeast, in the national and international juncture of well-successful experiences in management in institutional categories and leadership. This study becomes relevant to allow understand that the cultural practices of seridoenses that symbolize a capital generated by principles of trust, reciprocity, civic culture, as a driving force in overcoming the problems community and the conquest of democratic principles, worked for the school become a national reference in educational administration. Another aspect that made it natural that school was the collective creation of educational project with the participation and civic culture of self-evaluation as a way to understand the institutional practice and establish guidelines to improve the teaching and practice management in its many dimensions educational, social, administrative - financial and legal

Escola e gênero : representações de gênero na escola

The study Escola e Gênero: representações de gênero na escola show us the social man made, starting of an analysis in the having fun time in the children´s life and how it´s an important aspect of the building childish universe simbolic. My analysis started in a children´s daily at school and how they noticed the play value od dominant society. Our propouse is think about the linking between ideology, representations and gender like the children´s knowledge in the school activities. The toy, an instrument which is noticed and exist in the funny activities, is full of cultural concepts of male and female parts. Your color, lines, functions and the way you manipulate is driven of gender cathegories. In the scool, the ideological concepts have it´s important way which is to domesticate the feelings, the desires; categorize and normalize them without be known by the educational employers. In the children´s education, the funny time is noticed by others ways and turned as important as others subjects. By the way it´s not noticed by the school, like another thing which isn´t a funny moment. And it´s exactly here in the school funny time, the school did your cultural power of separete the gender and your extencions, feed by the society, generaly, in favor of the man whose woman is your subordinate. This ways of analysis help the society and the school universe about the funny time e how they are important in the Man made life. And how the toys bring the concepts and addicted thinking, ideological which put the power in the stages, without equal, addicted feelings around the gender concepts. I read and used the theories of Kishimoto, Berger & luckmann, Brougère, Sousa Filho, Bourdieu, Badinter, Geertz, Grossi, Louro, Foucault, among others

Da informação ao conhecimento :o jornalismo científico na contemporaneidade

The purpose of this dissertation is to analyze the actual nature of the Scientific Journalism, studying the historical facts from these informations segment, their matters production and the news industries that work with these specific niche of the contemporary journalism. It is taken into account the educational potential of the specialized journalism and it is considered the communication as a transdiciplinary science. To get into this point it was elected as an analyze category the Reception it Mediation Studies specially the north-americans theories besides the utilization also of the reportage concept to identify how to establish the epistemological relations between Communication and Education. Among the objectives of this dissertation are the investigation of the scientific character of the journalism; the analysis of the theoretical currents of Pedagogy that are based on the theory of Social Communication, as for example the Total Language and the analysis of the industrial and technological characteristics of the most important scientific and cultural magazines of Brazil, Northeast and Natal

Praxiologia, representação social de menopausa e práticas educativas de enfermeiras na estratégia saúde da família

This research, whose theme is related to climacteric, aims to know the social representation of menopause developed by the nurses working for Estratégia Saúde da Família (Family Health Strategy) in João Pessoa PB, as well as identifying its structure and verifying the way it interferes with the assistance and educational practices to the climacterial user. In the theoretical level, it is based on a model that articulates the social representations theory, the central nucleus complementary theory and the central concepts of Pierre Bourdieu s praxiology: habitus, cultural capital, social field and symbolic power. A hundred and forty-seven female nurses who work for Estratégia Saúde da Família (Family Health Strategy) in João Pessoa (PB) took part in this research, and the data collection period was from February 2008 to March 2009. As to the methods and techniques, we used the method to determine the central nucleus based on the free association of words, a questionnaire to identify certain regularities that constitute the nurses habitus, and the semi-structured interview to explore opinions and attitudes when facing assistance situations and educational practices and to collect other relevant information. The data analysis was developed, when referring to the free associations, with the help of the EVOC software, which is a group of articulated programs which carry out the statistical analysis of the evocations and the identification of the possible elements of both the central nucleus and the peripheral system of the social representation. As to the questionnaire, we used the descriptive statistical analysis and the analysis of correlation between the variables. The interviews were submitted to a categorical analysis of the content. The EVOC result indicated that the cognition hormone was the only element of the central nucleus of the social representation of menopause. Due to its symbolic value and structuring power, this central nucleus ensures the strict and, at the same time, flexible character of the representational content. The analysis of the social advancement, of some fundamental features of the group habitus, as well as the analysis of its insertion in the health field and of the attitudinal opinions and dispositions concerning the assistance given to the climacterial user, and the analysis of the pedagogical dimension of this assistance, all these analyses lead to the conclusion that the nurses who took part in this research share a social representation of the menopause resulting from the association of different technical and scientific knowledge. These derive from the biomedical pattern as well as from hegemonic values which disqualify old age and overvalue youth, from pedagogical conceptions arising from patterns that are presently regarded as authoritative and old-fashioned and from cultural references (responsible for the semantic variations concerning the central nucleus) which are specific to the subgroups the nurses belong to. This research enables the creation of opportunities for discussion between active nurses working for Estratégia Saúde da Família, and the nurses who are teachers at institutions of higher education, aiming at linking theory to practice, so that they can find ways of thinking about the climacteric and working, in a more comprehensive way, with users who are experiencing this stage of life

Despertando responsabilidade social no ensino médio por meio de temáticas associadas à física nuclear

Many discussions about the role of the school are on the agenda, in an increasingly complex society. Sociologists, educators, anthropologists, researchers of different areas seek that role. The objective of this dissertation is to contribute what we can consider the central role for the physics teaching, citizenship training. We have elaborated a didactic proposal to increase the interest of high school students on issues of social relevance and, throughout it, to promote the formation of attitudes of social responsibility, enhancing the formation of a more politically and socially active citizen. For the preparation of the proposal, studies were made on education for citizenship and on attitudes change, using as its main theoretical foundation the researches on the Science, Technology and Society curricular emphasis. The teaching of Nuclear Physics was integrated to our proposal, due to its pedagogical potential for the discussion of social, political and economic subjects related to scientific concepts and associated technologies. The educational proposal we have produced was applied on a high school class of a private school at Natal-RN. It was composed from the controversial issue involving the installation of nuclear power plants in Brazilian northeast. The methodology of role playing, in which students assumed social roles and produced specific subsidies for a public hearing and a later referendum, both simulated. In the analysis of the implementation of the proposal, we highlighted the difficulties but also the possibilities and the relevance of exercising skills such as reasoning, finding information, and arguing about of social problems. The results of the research showed the possibility of meaningful learning on Nuclear Physics contents, through this social, political, economic, scientific and technological contextualization using a controversial and real issue together with mechanisms that trigger for greater popular participation, as public hearing. It has also been identified changes in attitude by some students about issues related to Nuclear Physics. We hope, through this dissertation, to contribute to the formation of future citizens as well as to the initiative of teachers-researchers with pedagogical aims similar to those in the present work

Simulation Tools for Power Electronics Courses Based on Java Technologies

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Time-series-based maximization of distributed wind power generation integration

Energy policies and technological progress in the development of wind turbines have made wind power the fastest growing renewable power source worldwide. The inherent variability of this resource requires special attention when analyzing the impacts of high penetration on the distribution network. A time-series steady-state analysis is proposed that assesses technical issues such as energy export, losses, and short-circuit levels. A multiobjective programming approach based on the nondominated sorting genetic algorithm (NSGA) is applied in order to find configurations that maximize the integration of distributed wind power generation (DWPG) while satisfying voltage and thermal limits. The approach has been applied to a medium voltage distribution network considering hourly demand and wind profiles for part of the U.K. The Pareto optimal solutions obtained highlight the drawbacks of using a single demand and generation scenario, and indicate the importance of appropriate substation voltage settings for maximizing the connection of MPG.

Plasma concentrations and behavioral, antinociceptive, and physiologic effects of methadone after intravenous and oral transmucosal administration in cats

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)