Kehittyvien markkinoiden kasvu - uudet haastajat

Maailman talouden kehittyessä nousee kehittyvien markkinoiden joukosta jatkuvasti uusia haastajia jo kehittyneille markkinoille. Tässä tutkimuksessa tavoitteena on löytää kehittyvien markkinoiden talouskasvuun vaikuttavia tekijöitä, joiden perusteella kehittyviä markkinoita voidaan vertailla sekä arvioida niiden tulevaa kehitystä valituilla mittareilla. Tietyn markkinan talouskasvuun vaikuttavat tekijät voidaan jakaa valtion sisäisiin ja ulkoisiin tekijöihin. Näitä tekijöitä on runsaasti ja niiden tärkeys vaihtelee valtioittain. Talouskasvuun vaikuttavista tekijöistä mittareina tässä tutkimuksessa käytetään bruttokansantuotetta, koulutustasoa, poliittista vakautta, suoria ulkomaisia investointeja sekä kansainvälistä kilpailukykyä. Vertailemalla kehittyvien markkinoiden tuloksia edellä mainituilla mittareilla potentiaalisimmiksi tulevaisuuden kehittyneiksi markkinoiksi tunnistettiin Chile ja Malesia. Chilen talouskasvua tukevat kaivosteollisuus sekä sijoittajaystävällinen lainsäädäntö. Suurimmat kasvun hidasteet Chilessä ovat heikko koulutustaso sekä erittäin suuri riippuvuus Kiinan talouskasvusta. Malesian vahvuuksia ovat kehittynyt liiketoimintaympäristö sekä vahva tahto kehittyä. Valtion heikkouksina ovat heikko koulutustaso sekä suuri riippuvuus öljyntuotannosta.

Quantitative Analysis of Novel Prostate Cancer Markers in Tissue

Prostate cancer is a heterogeneous disease affecting an increasing number of men all over the world, but particularly in the countries with the Western lifestyle. The best biomarker assay currently available for the diagnosis of the disease, the measurement of prostate specific antigen (PSA) levels from blood, lacks specificity, and even when combined with invasive tests such as digital rectal exam and prostate tissue biopsies, these methods can both miss cancers, and lead to overdiagnosis and subsequent overtreatment of cancers. Moreover, they cannot provide an accurate prognosis for the disease. Due to the high prevalence of indolent prostate cancers, the majority of men affected by prostate cancer would be able to live without any medical intervention. Their latent prostate tumors would not cause any clinical symptoms during their lifetime, but few are willing to take the risk, as currently there are no methods or biomarkers to reliably differentiate the indolent cancers from the aggressive, lethal cases that really are in need of immediate medical treatment. This doctoral work concentrated on validating 12 novel candidate genes for use as biomarkers for prostate cancer by measuring their mRNA expression levels in prostate tissue and peripheral blood of men with cancer as well as unaffected individuals. The panel of genes included the most prominent markers in the current literature: PCA3 and the fusion gene TMPRSS2-ERG, in addition to BMP-6, FGF-8b, MSMB, PSCA, SPINK1, and TRPM8; and the kallikrein-related peptidase genes 2, 3, 4, and 15. Truly quantitative reverse-transcription PCR assays were developed for each of the genes for the purpose, time-resolved fluorometry was applied in the real-time detection of the amplification products, and the gene expression data were normalized by using artificial internal RNA standards. Cancer-related, statistically significant differences in gene transcript levels were found for TMPRSS2-ERG, PCA3, and in a more modest scale, for KLK15, PSCA, and SPINK1. PCA3 RNA was found in the blood of men with metastatic prostate cancer, but not in localized cases of cancer, suggesting limitations for using this method for early cancer detection in blood. TMPRSS2-ERG mRNA transcripts were found more frequently in cancerous than in benign prostate tissues, but they were present also in 51% of the histologically benign prostate tissues of men with prostate cancer, while being absent in specimens from men without any signs of prostate cancer. PCA3 was shown to be 5.8 times overexpressed in cancerous tissue, but similarly to the fusion gene mRNA, its levels were upregulated also in the histologically benign regions of the tissue if the corresponding prostate was harboring carcinoma. These results indicate a possibility to utilize these molecular assays to assist in prostate cancer risk evaluation especially in men with initially histologically negative biopsies.

The Effect of Plant Closures on Market Value: Empirical Evidence from Pulp and Paper Industry 2004-2012

The aim of this study was to research how plant closure announcements affect the market value of the largest pulp and paper industry companies in the world. Also the effect of announcements on competitors was researched and whether the location of plants, timing, reasons for the closures, and characteristics of the closing firms and competitors have an impact on the results. The overall sample included 57 events in the years 2004-2012 and event study was used as a research method. Main theories were signaling theory and spillover effect. According to empirical results, investors consider plant closure announcements as a positive signal for market value. The spillover effect on competitors was, on average, positive and characteristics of the firms and closures had an effect on the results. Furthermore, the market generally predicted the closures and overreacted to them on the announcement day and after it. It is possible for corporate management and investors to learn from the results and use them as support for their decision making.

The dominions of the Czar of Russia Alba or Great Duke of Moscovia in which are the Dukedoms of Moscow, Wolodimer, Rezan, Worotin, Novogorod-Sewierski, Czernihow, Smolensko, Reschow, Twer, Novogorod-Weliki, Biele Jezora, Wologda, .. /

1 kartta :, käsinvär. ;, 57 x 88 cm, lehti 62,5 x 92,5 cm

La Lapponia Russa coi Governi di Olonechoi, Carelia, Bielozero, ed Ingria Nella Russia Europea di nuova projezione

1 kartta :, käsinvär. ;, 40,5 x 31 cm, lehti 47,7 x 38,8 cm

Scandinavia and its confines, in which are the Kingdoms of Sweden, Denmark, and Norway, divided into their principall provinces viz. Under the crown of Sweden, those of Gothland, Sweden, Lapland, Finland, Ingria, and Livonia; Under the crown of Denmark, those of Jutland, Sleswick, Zealand, Fyonie, &c. In Denmark those of Agger, Dronthem, and Wardhous, in Norway /

1 kartta :, käsinvär. ;, 56,4 x 86,7 cm, lehti 62,5 x 91,5 cm

Charte von dem Europäischen Russland / berichtiget im Jahre 1817.

1 kartta : käsinvär. ; 40,7 x 29,7 cm, lehti 48,8 x 38,7 cm.

Carte de la partie européenne de l'empire de Russie, avec l'indication des chemins de poste, ainsi que des douanes frontières et de la repartition actuelle en gouvernements et districts /

1 kartta kahdellatoista lehdellä :, käsinvär. ;, n. 136 x 158 cm, lehdet n. 34 x 52,5 cm

Handkarta öfver Finland för skolorna af R. Hult

1 kartta :, vär. ;, 62,8 x 46,5 cm, lehti 71 x 55 cm

Suomen käsikartta kouluja varten /

1 kartta :, vär. ;, 62,8 x 46,7 cm, lehti 66 x 49,5 cm

Suomen käsikartta Handkarta öfver Finland /

1 kartta :, vär. ;, 70,1 x 51,5 cm, lehti 78,8 x 58,2 cm

Suomen käsikartta /

1 kartta :, vär. ;, 70,4 x 52 cm, lehti 74,5 x 55,3 cm

Carte internationale du monde au 1:1000000 Kansainvälinen maailmankartta 1:1000000 = Internationella världskartan 1:1000000 (N.P-34)

1 kartta :, vär. ;, 65 x 81 cm

Karta öfver Finland (Sektionen F5)

1 kartta :, vär. ;, 51 x 42,9 cm, lehti 58 x 50,3 cm

Nova tabula magni ducatus Finlandiae in provincias divisa, multis locis aucta et correcta pre F. de Witt

1 kartta :, käsinvär. ;, 44,2 x 53,4 cm, lehti 53 x 62 cm