Santiago de Compostela. Pilgerarchitektur und bildliche Repräsentation in neuer Perspektive

Die Kathedrale von Santiago de Compostela, als Ziel und Höhepunkt der Pilgerwege zum Jakobsgrab, darf heute mehr denn je Aufmerksamkeit beanspruchen, nicht nur als Ziel des Jakobsweges, sondern vor allem als architektonische und kulturgeschichtliche Quelle. Das mehrjährige Forschungsprojekt von Bernd Nicolai, Universität Bern und Klaus Rheidt, Universität Cottbus, 'Die Kathedrale von Santiago de Compostela - Gestalt, Funktion und Programm', das den Bau und seinen architektur- und kunstgeschichtlichen Kontext von Grund auf neu untersucht, legt hier eine Zwischenbilanz vor. Der Band präsentiert erstmalig Ergebnisse zu Bauverlauf und Ausstattung auf der Basis einer neuen Bauforschung, Baugeschichte und Quellenanalyse und konfrontiert sie mit aktuellen internationalen Forschungen in Spanien, den USA, der Schweiz, Deutschland, England und Frankreich zum Themenbereich der Pilgerstraßenarchitektur und -skulptur.

CHARACTERIZATION AND TREATMENT OF A NOVEL MOUSE MODEL OF TSC-ASSOCIATED AUTISM

Tuberous sclerosis complex (TSC) is a dominant tumor suppressor disorder caused by mutations in either TSC1 or TSC2. The proteins of these genes form a complex to inhibit the mammalian target of rapamycin complex 1 (mTORC1), which controls protein translation and cell growth. TSC causes substantial neuropathology, often leading to autism spectrum disorders (ASDs) in up to 60% of patients. The anatomic and neurophysiologic links between these two disorders are not well understood. However, both disorders share cerebellar abnormalities. Therefore, we have characterized a novel mouse model in which the Tsc2 gene was selectively deleted from cerebellar Purkinje cells (Tsc2f/-;Cre). These mice exhibit progressive Purkinje cell degeneration. Since loss of Purkinje cells is a well-reported postmortem finding in patients with ASD, we conducted a series of behavior tests to assess if Tsc2f/-;Cre mice displayed autistic-like deficits. Using the three chambered social choice assay, we found that Tsc2f/-;Cre mice showed behavioral deficits, exhibiting no preference between a stranger mouse and an inanimate object, or between a novel and a familiar mouse. Tsc2f/-;Cre mice also demonstrated increased repetitive behavior as assessed with marble burying activity. Altogether, these results demonstrate that loss of Tsc2 in Purkinje cells in a haploinsufficient background lead to behavioral deficits that are characteristic of human autism. Therefore, Purkinje cells loss and/or dysfunction may be an important link between TSC and ASD. Additionally, we have examined some of the cellular mechanisms resulting from mutations in Tsc2 leading to Purkinje cell death. Loss of Tsc2 led to upregulation of mTORC1 and increased cell size. As a consequence of increased protein synthesis, several cellular stress pathways were upregulated. Principally, these included altered calcium signaling, oxidative stress, and ER stress. Likely as a consequence of ER stress, there was also upregulation of ubiquitin and autophagy. Excitingly, treatment with an mTORC1 inhibitor, rapamycin attenuated mTORC1 activity and prevented Purkinje cell death by reducing of calcium signaling, the ER stress response, and ubiquitin. Remarkably, rapamycin treatment also reversed the social behavior deficits, thus providing a promising potential therapy for TSC-associated ASD.

Proceedings of the 23rd Annual Biochemical Engineering Symposium

The 23rd Annual Biochemical Engineering Symposium was held at the University of Oklahoma on April 17, 1993. The objectives of the symposium were to provide 1) a forum for informal discussion of biochemical engineering research being carried at the participating universities and 2) an opportunity for students to present and publish their work. Thirteen papers presented at the symposium are included in the proceedings. Because final publication usually takes place in refereed journals, the articles included here are typically brief and often cover work in progress. The program of the symposium and a list of participants are included in the proceedings. ContentsA Low-Cost Bioreactor Strategy for RNA Synthesis, H. Anthony Marble, Eleni Chrisikos, and Robert H. Davis Development of a CELSS Bioreactor: Oxygen Transfer and Micromixing in Parabolic Flight, P.E. Villeneuve, K.S. Wenger, B.G. Thompson, T. Kedar, and E.H. Dunlop Scale-up of Dexter Murine Bone Marrow Cultures Utilizing a Three-Dimensional Fiberglass Support Matrix, John G. Highfill, Paul Todd, Steve Haley, and Dhinaker Kompala Modeling and Estimation of States of Recombinant Fermentations Using Nonlinear Input/Output Models, Vicotr M. Saucedo and M. Nazmul Karim Deadent Microfiltration of Bovine Serum Albumin Suspension Through Yeast Cake Layers and Assymetric Polymeric Membranes, Naveen Arora and Robert H. Davis Monitoring the Fate of Toluene and Phenol in the Rhizosphere, N. Muralidharan, Lawrence C. Davis, and Larry E. Erickson Hydrodynamic Motions Associated with Bubble Coalescence and Breakup, T.Y. Yiin, L.A. Glasgow, and L.E. Erickson Expression and Purification of a-Human Atrial Natriuretic Peptide in Escherichia coli by Fusion with L-Asparaginase, Nien-Tung Ma and Roger G. Harrison High Pressure Crystallization of Proteins, Mungara V. Saikumar, Charles E. Glatz, and Maurice A. Larson Structure/Function Relationships in the Catalytic and Starch Binding Domains of Glucoamylase, Pedro M. Coutinho, Clark Ford, Peter J. Reilly Cellular Responses of Insect Cell Spodoptera frugiperda to Environmental Stresses, Paul Yeh, Grace Y. Sun, Gary A. Weisman, Rakesh Bajpai A Novel Approach to Understanding the Antimicrobial Activity of Peptides, Naveen Pathak, Marie-Helene Janna, Gael Ruche, David McCarthy, and Roger Harrison Mass Transfer in the Bioremediation of Soils Contaminated with Trapped Non-Aqueous Phase Liquids, Xiaoqing Yang, Larry E. Jacobson, and L.T. Fan

Geochemistry of basement clasts from sediment core CRP-3 in the ross Sea, Antarctica

Distribution patterns and petrographical and mineral chemistry data are described for the most representative basement lithologies occuring as clast in the c. 824 m thick Tertiary sedimentary sequence at the CRP-3 drillsite. These are granule to bolder grain size clasts of igneous and metamorphic rocks. Within the basement clast assemblage, granitoid pebbles are the predominant lithology. They consist of dominant grey biotic-bearing monzogranite, pink biotite-hornblende monzogranite, and biotite-bearing leucomomonzgranite. Minor lithologies include: actinolite-bearing leucotonalite, microgranite, biotite-hornblende quartz-monzonitic porphyr, and foliated biotic leucomonzogranite. Metamorphic clasts include rocks of both granitic and sedimentary derivation. They include mylonitic biotic orthogneiss, with or without garnet, muscovite-bearing quartzite, sillimanite-biotite paragneiss, biotite meta-sandstone, biotite-spotted schist, biotite-clacite-clinoamphibole meta-feldspathic arenite, biotite-calcite-clinozoisite meta-siltstone, biotite±clinoamphibole meta-marl, and graphite-bearing marble. As in previous CRP drillcores, the ubiquitous occurence of biotite±hornblende monzogranite pebbles is indicative of a local provenance, closely mirroring the dominance of these lithologies in the on-shore basement, where the Cambro-Ordovician Granite Harbour Intrusive Complex forms the most extensively exposed rock unit.

The statuary collection held at the baths of Zeuxippus (Ap 2) and the search for Constantine's museological intentions

Constantino pretendía enseñar al mundo su Constantinopla como la Nueva (la tercera) Troya, el más acabado retrato de la nueva paidea de inspiración griega y romana. Él mismo y su equipo dispusieron de no más que seis años para planear y reconstruir una ciudad entera, la antigua Bizancio; y las artes plásticas, en especial la escultura, ejercieron un rol determinante en todo ese proceso público. Volviendo una vez más la mirada hacia los restos arqueológicos y la descripción literaria de Cristodoro (Antología Griega, libro II) de la colección de estatuas de los Balnearios del Zeuxipo, el presente artículo desenvuelve una lectura museológica de estas estatuas, buscando encuadrarlas en el plan arquitectónico global de Constantino para su nueva capital del Imperio.

'Muchas artes' : Escultura, teatro y literatura en la poética de Sergio Chejfec

El presente artículo busca analizar las formas en que dialogan literatura y teatro en la poética de Sergio Chejfec partiendo de la hipótesis de que esta relación debe pensarse como una confrontación, un "hacer contra", que implica un movimiento de proximidad y exclusión, antes que un mero uso, asimilación u homogeneización. Para esto, vuelve a Baroni: un viaje para observar cómo se plantea esta interacción en el contexto de la puesta en contacto del narrador-escritor con toda una serie de artistas. Luego, muestra cómo, a partir de esa articulación inicial, la misma se torna central en La experiencia dramática como modo de armar el relato y de dramatizar sus posibilidades.