[Bula]

Bula fechada en Roma a 22 de Junio de 1709

El hombre moribundo : oratorio que se canto en la iglesia de la Real Congregacion de San Felipe Neri de ... Valencia, año de 1702

Sign.: A12

Traitté des scrupules de leurs causes, de leurs especes ... [Texto impreso]

Autor tomado de Barbier, IV, col. 787

Por el Excelentissimo Señor Arçobispo, canonigos, y Cabildo de la Santa Iglesia de Valencia, con los padres de la Compañia de Iesus [Texto impreso]

Sign.: A-H2, I1

Censura y pareceres de los dotores telogos, canonistas y legistas, sobre la pretensa descomunion nulliter... contra don Iosef Sanz arcediano de Alzira, canonigo de la..., Metropolitana Iglesia de Valencia, vicario general... [Texto impreso]

Texto fechado en Valencia, 1649

Gerardi Joan. Vossii Etymologicon linguae latinae praefigitur eiusdem de literarum permutatione tractatus [Texto impreso]

Tit. en anteport. : Gerardi Joannis Vossii De literarum permutatione tractatus

FUNDASE en derecho la aprehension que la S.R.A. de Valencia hizo de vnas letras declaratorias del Auditor de la Camara, a instancia del Dotor don Ioseph Sanz Arcediano de Alzira. [Texto impreso]

Tit. tomado de encabezamiento de texto

Sermon de la Purissima Concepcion...En la Santa Metropolitana Iglesia de Valencia,en el dia de su fiesta 8.de Diziembre,año 1648 [Texto impreso]

Sign.: A14

Villancicos que se han de cantar la noche de Nauidad, en la Iglesia Metropolitana de Valencia, este año de 1687 [Texto impreso]

Sign.: A8

ANÁLISE COMPARATIVA DO NÚMERO DE CONTATOS OCLUSAIS AO FINAL DA FASE DE CONTENÇÃO, E APÓS UM PERÍODO DE 5 ANOS, EM PACIENTES COM MÁ-OCLUSÃO DE CLASSE II, TRATADOS COM EXTRAÇÕES DE 4 PRÉ- MOLARES.

Realizou-se um estudo comparativo do número de pontos de contato oclusais na posição de máxima intercuspidação habitual em uma amostra composta por 14 pacientes leucodermas, sendo 9 do sexo feminino e 5 do sexo masculino, com máoclusão de Classe II, divisão 1a de Angle, tratados ortodonticamente pela técnica de Edgewise, com extrações dos 4 primeiros pré-molares. Estes pontos foram registrados em dois tempos: T1 - ao final da fase de contenção superior e T2 - após um período médio de 5,2 anos. A contagem dos contatos oclusais foram realizadas nos arcos superior e inferior, separadamente, para as regiões anterior e posteriores. Depois da análise estatística, pôde-se concluir que não houve diferença estatisticamente significante entre o número médio de contatos oclusais nos diferentes períodos estudados.(AU)

ATP-dependent uptake of natural product cytotoxic drugs by membrane vesicles establishes MRP as a broad specificity transporter.

MRP is a recently isolated ATP-binding cassette family transporter. We previously reported transfection studies that established that MRP confers multidrug resistance [Kruh, G. D., Chan, A., Myers, K., Gaughan, K., Miki, T. & Aaronson, S. A. (1994) Cancer Res. 54, 1649-1652] and that expression of MRP is associated with enhanced cellular efflux of lipophilic cytotoxic agents [Breuninger, L. M., Paul, S., Gaughan, K., Miki, T., Chan, A., Aaronson, S. A. & Kruh, G. D. (1995) Cancer Res. 55, 5342-5347]. To examine the biochemical mechanism by which MRP confers multidrug resistance, drug uptake experiments were performed using inside-out membrane vesicles prepared from NIH 3T3 cells transfected with an MRP expression vector. ATP-dependent transport was observed for several lipophilic cytotoxic agents including daunorubicin, etoposide, and vincristine, as well as for the glutathione conjugate leukotriene C4 (LTC4). However, only marginally increased uptake was observed for vinblastine and Taxol. Drug uptake was osmotically sensitive and saturable with regard to substrate concentration, with Km values of 6.3 microM, 4.4 microM, 4.2 microM, 35 nM, and 38 microM, for daunorubicin, etoposide, vincristine, LTC4, and ATP, respectively. The broad substrate specificity of MRP was confirmed by the observation that daunorubicin transport was competitively inhibited by reduced and oxidized glutathione, the glutathione conjugates S-(p-azidophenacyl)-glutathione (APA-SG) and S-(2,4-dinitrophenyl)glutathione (DNP-SG), arsenate, and the LTD4 antagonist MK571. This study establishes that MRP pumps unaltered lipophilic cytotoxic drugs, and suggests that this activity is an important mechanism by which the transporter confers multidrug resistance. The present study also indicates that the substrate specificity of MRP is overlapping but distinct from that of P-glycoprotein, and includes both the neutral or mildly cationic natural product cytotoxic drugs and the anionic products of glutathione conjugation. The widespread expression of MRP in tissues, combined with its ability to transport both lipophilic xenobiotics and the products of phase II detoxification, indicates that the transporter represents a widespread and remarkably versatile cellular defense mechanism.

New Approaches for Teaching Soil and Rock Mechanics Using Information and Communication Technologies

Soil and rock mechanics are disciplines with a strong conceptual and methodological basis. Initially, when engineering students study these subjects, they have to understand new theoretical phenomena, which are explained through mathematical and/or physical laws (e.g. consolidation process, water flow through a porous media). In addition to the study of these phenomena, students have to learn how to carry out estimations of soil and rock parameters in laboratories according to standard tests. Nowadays, information and communication technologies (ICTs) provide a unique opportunity to improve the learning process of students studying the aforementioned subjects. In this paper, we describe our experience of the incorporation of ICTs into the classical teaching-learning process of soil and rock mechanics and explain in detail how we have successfully developed various initiatives which, in summary, are: (a) implementation of an online social networking and microblogging service (using Twitter) for gradually sending key concepts to students throughout the semester (gradual learning); (b) detailed online virtual laboratory tests for a delocalized development of lab practices (self-learning); (c) integration of different complementary learning resources (e.g. videos, free software, technical regulations, etc.) using an open webpage. The complementary use to the classical teaching-learning process of these ICT resources has been highly satisfactory for students, who have positively evaluated this new approach.

Ledger for the Classes of 1703-1718, 1703-1731

The parchment-bound hardcover folio volume contains accounts for Fellows, Tutors, the President, and members of the Classes of 1703-1718. Payments were often made with bills of credit, money, and notes. The Steward's accounts with the College are interspersed in the volume.

Audited accounts, 1713-1745

The parchment-bound hardcover folio volume contains the Steward's accounts with the College from March 20, 1712/13 through August 9, 1745. The accounts are arranged as Harvard College's debits to the Steward with entries listing the Steward's expenses for students, salaries, and provisions and equipment, and the Steward's credits collected from the quarterly bills, arranged by type of charge (such as study rent, payments from the Butler, and repairs).

Accounts with Harvard College, 1719-1722

The thin paper-covered notebook contains the Steward's accounts with Harvard College kept by Steward Andrew Bordman II from 1719-1722. Arranged by quarters, the entries list money collected by the Steward from students, and money paid for food supplies, household provisions, the Butler's salary, and for services provided to the College.