Tractatus de alimentis Do. Ioannis Petri Surdi Casalensis iurisconsulti, et senatoris praeclariss. : titulis, seu partibus nouem distinctus, totam alimentorum materiam exactissimè complectens, omnibus tùm theoricis, tùm practicis apprimè vtilis, ac necessarius.

Signatures: [dagger]⁶ a-k⁶ A-3N⁶ 3O⁸.

Aurea ac perutilis lectura clariss. ac iuris interpretis consummatiss. D. Martini de Caratis, Laudensis, in lucrosissimo & prae caeteris practicabili opere feudorum : ad vtilitatem studentium summarijs locupletata & à mendis innumeris repurgata : in fine adiuncta est disputatio longè vtilissima Ioannis de Anania, De reuocatione feudi alienati, ob quotidianum & crebrum eius vsum & autoris illustrissimi authoritatem ...

1 Lipen., 202 (Feuda)

Hugonis Grotii de jure belli ac pacis libri tres : cum annotatis auctoris, nec non J. F. Gronovii notis, & J. Barbeyracii animadversionibus, commentariis insuper locupletissimis Henr. l.b. de Cocceii ... sub titulo Grotii illustrati antea editis, nunc ad calcem cujusque capitis adjectis : insertis quoque observationibus Samuelis l.b. de Cocceii ... : adduntur tandem ipsius Grotii Dissertatio de mari libero, ac Libellus singularis de aequitate, indulgentia et facilitate.

Vols. 2 and 4 have at end Bibliopolae monitum = Avis du libraire, about pricing in various European currencies in 1751 and 1752.

Loci argvmentorvm legales. Nunc recens recogniti, diligentia magna emendati, summarijs singulis locis praefixis illustrati, ac P. Praetij adnotatiunculis doctissimis ad marginem adscriptis locupletati.

Mode of access: Internet.

Syntagma jurisprundentiae, secundum̀ ordinem Pandectarum concinnatum, quo solida Juris fundamenta traduntur, Digestorum, & affines Codicis, Novellarum, ac Juris Canonici Tituli methodicè explicantur, controversiae nervosè resolvuntur, &, quid in foro usum habeat, monetur /

1st vol. of 2 vol. set.

Dn. Henningi Goeden Hauelbergensis iureconsulti clarissimi Iudiciarij ordinis processus : item, domini Odofredi Summa de libellis formandis : cum indice rerum ac verborum notatu dignorum.

Includes index.

Tractatus de legibus ac Deo legislatore, : in decem libros distributus. /

Includes indexes.

Tractatus de legibus ac Deo legislatore : in decem libros distributus /

Text in 2 columns; capital A-B-C-D in the joint space between the columns; printed marginalia.

Development of a web-service-agents-based family wealth management system

The roiling financial markets, constantly changing tax law and increasing complexity of planning transaction increase the demand of aggregated family wealth management (FWM) services. However, current trend of developing such advisory systems is mainly focusing on financial or investment side. In addition, these existing systems lack of flexibility and are hard to be integrated with other organizational information systems, such as CRM systems. In this paper, a novel architecture of Web-service-agents-based FWM systems has been proposed. Multiple intelligent agents are wrapped as Web services and can communicate with each other via Web service protocols. On the one hand, these agents can collaborate with each other and provide comprehensive FWM advices. On the other hand, each service can work independently to achieve its own tasks. A prototype system for supporting financial advice is also presented to demonstrate the advances of the proposed Webservice- agents-based FWM system architecture.

ENSINAR AS MEMÓRIAS Exegese histórico-social de Deuteronômio 6,20-25

O presente estudo exegético tem por objetivo analisar o texto de Deuteronômio 6,20-25 numa perspectiva histórico-social. Para tanto, revisa-se algumas discussões exegéticas acerca do texto. Compreende-o como um ensino familiar, das famílias livres e possuidoras de terra em Judá, no século VII.a.C. Nele, narrativamente são apresentados os atos redentores de Javé: o êxodo, a dádiva da terra e das leis. Dentre esses atos, destaca-se o êxodo, como fundamento da liberdade, e sua articulação com as leis. Por sua vez as leis são a forma de manutenção da liberdade, por meio da defesa do direito dos socialmente enfraquecidos. Nessa dinâmica da catequese familiar, duas categorias são importantes, ensino e memória.

Family resemblances? Ligand binding and activation of family A and B G-protein-coupled receptors

In April 2007, the Biochemical Society held a meeting to compare and contrast ligand binding and activation of Family A and B GPCRs (G-protein-coupled receptors). Being the largest class, Family A GPCRs usually receive the most attention, although a previous Biochemical Society meeting has focused on Family B GPCRs. The aim of the present meeting was to bring researchers of both families together in order to identify commonalities between the two. The present article introduces the proceedings of the meeting, briefly commenting on the focus of each of the following articles. ©The Authors.

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling:implications for family B G-protein-coupled receptors

Calcitonin receptor like-receptor is a family B G-protein coupled receptor (GPCR). It requires receptor activity modifying protein (RAMP) 1 to give a calcitonin gene-related peptide (CGRP) receptor. Little is known of how members of this receptor family function. Proline residues often form important kinks in alpha-helices. Therefore, all proline residues within the transmembrane helices of the receptor (Pro241, Pro244 in helix 4, Pro275 in helix 5, Pro321 and Pro331 in helix 6) were mutated to alanine. Pro241 Pro275, and Pro321 are highly conserved throughout all family B GPCRs. The binding of CGRP and its ability to stimulate cAMP production were investigated in mutant and wild-type receptors after transient transfection into COS-7 cells with RAMP1. The P321A mutation significantly decreased the pEC(50) for CGRP and reduced its affinity but did not change cell-surface expression. Antagonist binding [CGRP(8-37) and 1-piperidinecarboxamide N-[2-[[5amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-1-[(3 5-dibromo-4-hydroxyphenyl)methyl]-2-oxoethyl]-4-(1,4-dihydro-2-oxo-3(2H)-quina zolinyl) (BIBN4096BS)] was little altered by the mutation. Adrenomedullin-mediated signaling was disrupted when P321A was coexpressed with RAMP1, RAMP2, or RAMP3. The P331A mutant produced a moderate reduction in CGRP binding and receptor activation. Mutation of the other residues had no effect on receptor function. Thus, Pro321 and Pro331 are required for agonist binding and receptor activation. Modeling suggested that Pro321 induces a bend in helix 6, bringing its C terminus near that of helix 3, as seen in many family A GPCRs. This is abolished in P321A. P321A-I325P predicted to restore this conformation, showed wild-type activation. Modeling can also rationalize the effects of transmembrane proline mutants previously reported for another family B GPCR, the VPAC(1) receptor.

Heterodimers and family-B GPCRs:RAMPs, CGRP and adrenomedullin

RAMPs (receptor activity-modifying proteins) are single-pass transmembrane proteins that associate with certain family-B GPCRs (G-protein-coupled receptors). Specifically for the CT (calcitonin) receptor-like receptor and the CT receptor, this results in profound changes in ligand binding and receptor pharmacology, allowing the generation of six distinct receptors with preferences for CGRP (CT gene-related peptide) adrenomedullin, amylin and CT. There are three RAMPs: RAMP1-RAMP3. The N-terminus appears to be the main determinant of receptor pharmacology whereas the transmembrane domain contributes to association of the RAMP with the GPCR. The N-terminus of all members of the RAMP family probably contains two disulphide bonds; a potential third disulphide is found in RAMP1 and RAMP3. The N-terminus appears to be in close proximity to the ligand and plays a key role in its binding, either directly or indirectly. BIBN4096BS, a CGRP antagonist, targets RAMP1 and this gives the compound very high selectivity for the human CGRP(1) receptor.

Functional and biophysical analysis of the C-terminus of the CGRP-receptor; a family B GPCR

G-protein coupled receptors (GPCRs) typically have a functionally important C-terminus which, in the largest subfamily (family A), includes a membrane-parallel eighth helix. Mutations of this region are associated with several diseases. There are few C-terminal studies on the family B GPCRs and no data supporting the existence of a similar eighth helix in this second major subfamily, which has little or no sequence homology to family A GPCRs. Here we show that the C-terminus of a family B GPCR (CLR) has a disparate region from N400 to C436 required for CGRP-mediated internalization, and a proximal region of twelve residues (from G388 to W399), in a similar position to the family A eighth helix, required for receptor localization at the cell surface. A combination of circular and linear dichroism, fluorescence and modified waterLOGSY NMR spectroscopy (SALMON) demonstrated that a peptide mimetic of this domain readily forms a membrane-parallel helix anchored to the liposome by an interfacial tryptophan residue. The study reveals two key functions held within the C-terminus of a family B GPCR and presents support for an eighth helical region with striking topological similarity to the nonhomologous family A receptor. This helix structure appears to be found in most other family B GPCRs.