The Amplifier - v. 2, no. 14

In this issue...Dean Adami, M club, Red Rock, Bernice, Montana, Mineral Club, Mines Football, Sam Worcester, Professor Laity, Western Civilization class

The Amplifier - v. 9, no. 1

In this issue...New Faculty, Orediggers, Anderson-Carlisle, campus parking, cheerleaders, freshman class, Phil Judd, Mineral dressing, Coach Ed Simonich

The Amplifier - v. 9, no. 8

In this issue...Ceramic testing, Bob LeCoure, Butte Civic Center, Rotary Club, Saint Patrick's Day, First-Aid Class, Mine Rescue, Career Day, American Legion Baseball

The Amplifier - v. 9, no. 10

In this issue...Spanish class, Peace Corps, Coast Guard, NASA, Allen Winters, M-Days, Alumni Stadium, Chess Club, Charles Russell, computer class, Columbia Riding Club

A New Class Of Potential Chloroquine Resistance Reversal Agents For Plasmodia: Syntheses And Biological Evaluation 1-[(3’-Diethylaminopropyl)-3-(Substituted Phenylmethylene)-Pyrrolidines

1-[(3’-Diethylaminopropyl)-3-(substitutedphenylmethylene) pyrrolidines] were synthe-sized and evaluated for CQ resistant reversal activity. The compounds of the series elicit better biological response than their phenyl methyl analogues in general. The most active compound 4b has been evaluated in vivo in details and the results are presented. The possible mode of action of the compounds of this series is by inhibition of the enzyme heme oxygenase, thereby increasing the levels of heme and hemozoin, which are lethal to the parasite.

Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds

Fifty members of a novel class of antimicrobial compounds, 2-(4-R-phenoxymethyl)benzoic acid thioureides, were synthesized and characterized with respect to their activities against three parasites of human relevance, namely the protozoa Giardia lamblia and Toxoplasma gondii, and the larval (metacestode) stage of the tapeworm Echinococcus multilocularis. To determine the selective toxicity of these compounds, the human colon cancer cell line Caco2 and primary cultures of human foreskin fibroblasts (HFF) were also investigated. The new thioureides were obtained in a three-step-reaction process and subsequently characterized by their physical constants (melting point, solubility). The chemical structures were elucidated by (1)H NMR, (13)C NMR, IR spectral methods and elemental analysis. The analyses confirmed the final and intermediate compound structures and the synthesis. The compounds were then tested on the parasites in vitro. All thioureides, except two compounds with a nitro group, were totally ineffective against Giardia lamblia. 23 compounds inhibited the proliferation of T. gondii, three of them with an IC(50) of approximately 1 microM. The structural integrity of E. multilocularis metacestodes was affected by 22 compounds. In contrast, HFF were not susceptible to any of these thioureides, while Caco2 cells were affected by 17 compounds, two of them inhibiting proliferation with an IC(50) in the micromolar range. Thioureides may thus present a promising class of anti-infective agents.

Copyright Exhaustion Rationales and Used Software: A Law and Economics Approach to Oracle v. UsedSoft

This article aims to provide courts and policymakers with an analytical framework that, building upon the traditional rationales of IP exhaustion doctrine, identifies factors which advocate for a modulation or flexibilization of the role of exhaustion in copyright law. Factors include (i) the personal features of acquirers of copies of copyrighted works, distinguishing between consumers and commercial users; (ii) whether post-sale restrictions have been adequately communicated to acquirers and have been agreed in the contract or license; (iii) the degree of complexity of the acquired goods and their prospects of productive uses and interoperability; (iv) the role of other exclusive rights in providing rightholders with indirect control over uses of the copies in the aftermarket; (v) the impact of post-sale restraints in preventing opportunism in long-term contracts and in reducing deadweight losses created by IP pricing; and (vi) the temporal scope of post-sale restraints. After setting out this analytical framework, the ECJ Judgement in Oracle v. UsedSoft is discussed.

Improving Chat in an Online Graduate Class

Introduction: Foundations of Health Information Sciences I is the first class many students take to introduce them to the field of health informatics. It is completely online, and uses optional weekly text-only chats to provide real time interaction between faculty and students. Chat sessions were very disorganized and difficult to follow, both real time and on the transcript. Research suggests that the disorganization contributes to cognitive load. [See PDF for complete abstract]

Macrofauna abundance and sediment characteristics during R/V Senckenberg cruise west of Sylt in september 2010

The continuously influence of human impacts on the seafloor and benthic habitats demands the knowledge of clearly defined habitats to assess recent conditions and to monitor future changes. In this study, a benthic habitat dominated by sorted bedforms was mapped in 2010 using biological, sedimentological and acoustic data. This approach reveals the first interdisciplinary analysis of macrofauna communities in sorted bedforms in the German Bight. The study area covered 4 km², and was located ca. 3.5 km west of island of Sylt. Sorted bedforms formed as sinuous depressions with an east west orientation. Inside these depressions coarse sand covers the seafloor, while outside predominantly fine to medium sand was found. Based on the hydroacoustic data, two seafloor classes were identified. Acoustic class 1 was linked to coarse sand (type A) found inside these sorted bedforms, whereas acoustic class 2 was related to mainly fine to medium sands (type B). The two acoustic classes and sediment types corresponded with the macrofauna communities 1 and 2. The Aoinides paucibranchiata-Goniadella bobretzkii community on coarse sand and the Spiophanes bombyx - Magelona johnstonii community on fine sand. A transitional community 3 (Scoloplos armiger - Ophelia community), with species found in communities 1 and 2, could not be detected by hydroacoustic methods. This study showed the limits of the used acoustic methods, which were unable to detect insignificant differences in the fauna composition of sandy areas.