976 resultados para Aug, Vincent


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Includes bibliographical references.

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Thesis (doctoral)--

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Mode of access: Internet.

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Thesis (doctoral)--Universite de Geneve.

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Editors: 1882/83-Aug./Sept. 1901, H. B. Adams.--Oct. 1901-Nov./Dec. 1907, J. M. Vincent (with J. H. Hollander and W. W. Willoughby, 1902-07)

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At head of title: Institut de France. Académie des sciences.

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From Jan. 1826-July 1830 title reads: American journal of education. In August 1830 the title was changed to American Annuals of Education and instruction. The numbers for August-Dec. 1830, however, were issued both under this later title (as 3d ser., b.1, no 1-4) and under the title American journal and annals of education and instruction, new ser., v.1 of the 3d ser. They are preceded by 24 pages ("Editor's address" and "Sketches of Hofwyl") reprinted from the numbers for Aug.-Dec. 1830) In 1838 the title was shortened to American annuals of education. Editors: 1826-29, Williams Russell.--1830-37, W.C. Woodbridge.--1837--38 W.A. Alcott.

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"The Dred Scott decision: speech, delivered, in part, at the anniversary of the American Abolition Society, held in New York, May 14th, 1857" on pages [25]-46, with half title page.

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Upstream AUGs (uAUGs) and upstream open reading frames (uORFs) are common features of mRNAs that encode regulatory proteins and have been shown to profoundly influence translation of the main ORF. In this study, we employed a series of artificial 5'-untranslated regions (5'-UTRs) containing one or more uAUGs/uORFs to systematically assess translation initiation at the main AUG by leaky scanning and reinitiation mechanisms. Constructs containing either one or two uAUGs in varying contexts but without an in-frame stop codon upstream of the main AUG were used to analyse the leaky scanning mechanism. This analysis largely confirmed the ranking of different AUG contextual sequences that was determined previously by Kozak. In addition, this ranking was the same for both the first and second uAUGs, although the magnitude of initiation efficiency differed. Moreover, similar to10% of ribosomes exhibited leaky scanning at uAUGs in the most favourable context and initiated at a downstream AUG. A second group of constructs containing different numbers of uORFs, each with optimal uAUGs, were used to measure the capacity for reinitiation. We found significant levels of initiation at the main ORF even in constructs containing four uORFs, with nearly 10% of ribosomes capable of reinitiating five times. This study shows that for mRNAs containing multiple uORFs/uAUGs, ribosome reinitiation and leaky scanning are efficient mechanisms for initiation at their main AUGs.

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Press Release from the School of Medicine Initiative published August 2004.