Escolhas de letras nas primeiras escritas infantis: função e unidade no discurso

The article deals, initially, from a theoretical point of view, the concept of function in the perspective of Vygotsky (2001), and functional equivalence from the point of view of Smith (1989) and articulates them with the letter funcion in the construction of words in discursive statements. Taking as reference these concepts, it was analysed writings of a student in early literacy at a school in a countryside city in the state of São Paulo, in a situation of writing letters of personal correspondence, whose data were collected in 2009 in order to determine which letters are chosen by the student and why they are chosen to record the speech. The concept of function in Vygotsky and the functional equivalence of Smith (1989) used for the analysis of corpus, revealed that the student’s decisions are characterized by diversity sources and criteria, and rely mainly on the basis that a letter can have the constitution of the word, in the process of enunciation, regardless of their phonetic correspondence. The letter, used as a basis, would lose its status as strictly technical element to achieve the status of a unit of sense since is a constituent part of discourse.

Influência da infecção endodôntica associada ou não à diabetes nos níveis da citocina pró-inflamatória IL-17 nos tecidos periapical, hepático e renal de ratos Wistar

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Proposta teórico-metodológica para análise de inserções parentéticas em chat educacional no ensino de língua espanhola =: Propuesta teórico-metodológica para el análisis de inserciones parentéticas en chat educacional en la enseñanza de lengua española

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Unidade da Pinacoteca de São Paulo de Botucatu

O antigo edifício do Fórum e Cadeia, de autoria do arquiteto Ramos de Azevedo, aparece no cenário do município de Botucatu como um importante elemento do imaginário social urbano e de forte valor arquitetônico e histórico. É possível perceber a presença de marcos e lugares que revelam uma leitura da arquitetura no centro histórico da cidade, inspirada no Ecletismo, e que compõem um conjunto de edifícios de interesse cultural neste espaço urbano. Este trabalho elabora uma análise detalhada da paisagem antiga e atual e quais são os registros histórico/culturais materializados no contexto urbano central de Botucatu e propõe adequar o edifício às novas funções urbanas contemporâneas, com o propósito de preservar o antigo Fórum de Botucatu e recuperar esta herança para cidade e seu valor patrimonial

Transplante de medula óssea para suporte de células tronco hematopoiéticas em cães acometidos por linfoma

Lymphoma represents the most prevalent hematopoietic malignancy in small animal medicine. It is highly responsible to chemotherapy and therefore several protocols are used as therapeutic tools. For that reason, the bone marrow transplantation, enshrined in human medicine through initial trial in canine patients, has increasingly become the focus of studies in order to make it a reality also in veterinary medicine. First, the treatment with the chosen chemotherapy protocol is made. As complete remission of lymphoma is observed, it must be initiated the bone marrow harvesting. The obtained material is subjected to the processes of erythrocyte depletion, plasma depletion, cryoprotectants addition, total nuclear cells counting, hematopoietic progenitor quantification, analysis of cell viability and freezing. Following that, with radiotherapy or application of cyclophosphamide, the conditioning phase of the patient who is receiving the transplantation is carried out. The bags containing hematopoietic stem cells are then thawed and transplanted into the receptor organism. Support with hematopoietic stem cells allows the use of lethal doses of chemotherapy or radiotherapy and has been shown to considerably raise the disease remission time and survival rate of the canine patients

Análise multitemporal de indicadores geoambientais como subsídio ao plano de gestão ambiental - Floresta Nacional de Ipanema - SP

The objective of this research was to conduct an analysis of multitemporal landscape Ipanema National Forest, located in the municipalities of Iperó, Capela do Alto and Araçoiaba da Serra – São Paulo estate, Brazil, considering the scenarios of 1965, 2007 and 2011. The multitemporal analysis, using aerial photographs and satellite images, contributed to the contextualization and spatialization of the evolution of the landscape area. Through analysis interpretation of the images, performed by means of supervised classification were obtained thematic maps of the area, equivalent to approximately 53 km2. Through geoprocessing techniques, especially Geographic Information Systems, it was possible the integration and manipulation of data, both spatial and statistical, allowing integrated analysis of data from the entire area of the National Forest of Ipanema. As the main result, we found that the Ipanema National Forest is in landscape evolution positive, with those 46 years examined the increase of native heavy foliage areas. Increasing from 7.1 km2 of the total area of dense vegetation in 1965 to 35.9 km2 in 2011. Overall, it was possible to realize a scenario landscape quite optimistic about the evolution of forest conservation area

Análise de fácies sedimentares e de paleocorrentes das sequências inferiores do grupo Itararé, Centro-Leste do estado de São Paulo

The Itararé Group is the record of one of the most significant glaciation events of the Gondwana. Of neocarboniferous-eopermian age, this unit has facies associations interpreted as resulted from shallow marine settings with glacial and deglacial water influence. The role of glaciers on the tectonic-sedimentary processes of the Itararé Group is striking, as typical facies such as diamictites, tilites, shales and rhythmites with dropstones are generated, besides the existence of glacially striated and polished surfaces. This work had as main goal to contribute to the geological knowledge of the Itararé Group in the central eastern portion of São Paulo State, using as basis outcrops from Itu, Salto and Porto Feliz, and also pertinent bibliographic data and well profiles located in the surrounding areas. About the stratigraphic framework, genetic association and paleogeography of these deposits, this work concludes that the area studied comprises the basal section of the Itararé Group. The stacking of the facies recognized during the field work begins with the striated and polished surfaces of the basement, described in Salto, superposed by tilites and diamictites with glacial movement features. Over these are the turbidites from Itu, associated with the glacier retreat. The outcrops of Porto Feliz are at the top of this succession, with deposits generated by flows with lateral and vertical variations, sometimes with prevalence of tractive conditions, and sometimes with sediments transported largely by suspension. Paleocurrent measurements show main flow directions towards NW, the same as glacial striae, suggesting the influence of reworking of sediments by the meltwater during deglacial periods

A aglomeração urbana de Piracicaba: uma análise da integração funcional entre os municípios sob a ótica do movimento pendular

The growth area of cities has resulted in a phenomenon of conurbation (or expressing tendency). This correspond to a combine of two or more urban cores, there are formations of conurbations. In this way, there are the formations of urban concentrations and can achieve the step metropolitan or not metropolitan. Besides, this kind of expansion generates many social and environmental problems related about habitation, rubbish, drain, and others. Piracicaba, a city in expansion, recently, shows evidences of conurbation not metropolitan around itself. Like this, the paulista government, at June, 26 of 2012, institutionalized the Urban Concentration of Piracicaba, a regional unity, intending the administration along with 22 cities. However, for this fact, must be taken into account functional integration among urban centers, because the number of municipalities are presented to compose a urban concentration of level not metropolitan. It has checked along this research, according with proposition about 22 cities. Thus, the objective of this research is identify and analyze the functional integration among participating municipalities through the commuting, in other words, the spatial displacement of people, important factor to be taken into account when defining urban concentration. Considering the displacement routine people, the commuting, also aimed identify the flow of public transport intercity travel among the cities of Piracicaba Regional Unity. Then, analyze the criteria used for establish the Piracicaba Regional Unity, if it was considered technical character or if it was prioritized the political character. To conduct this research, it was done the literature review related to the theme and data collection related lines of intercity transportation and often travel with ARTESP and companies responsible for it service

Análise socioeconômica e ambiental das populações tradicionais da Reserva de Desenvolvimento Sustentável (RDS) dos Quilombos de Barra do Turvo e Área de Proteção Ambiental (APA) do Planalto do Turvo, Mosaico de Jacupiranga/SP

As Unidades de Conservação são sub-divididas em duas categorias: Proteção Integral, com objetivos de manutenção do ecossistema livre da interferência humana na qual é permitido apenas o uso indireto; e de Desenvolvimento Sustentável, que tem por objetivo equilibrar a conservação da natureza com o uso sustentável dos recursos naturais. O Parque de Jacupiranga era localizado na região sul do estado de São Paulo, denominada Vale do Ribeira, sendo criado em 1961 com aproximadamente 141 mil ha e cerca de 8 mil moradores presentes no seu interior, incluindo comunidades tradicionais, quilombolas, e agricultores migrantes de outros estados. O mosaico de Jacupiranga foi criado em 2008, com o objetivo de atender reivindicações dos moradores que sofriam restrições de suas atividades por estar dentro de uma unidade de conservação de proteção integral, com isso, o antigo PEJ sofreu a recategorização, e foram criadas 3 unidades de proteção integral e 7 de uso sustentável na antiga área do parque. O objetivo foi analisar as mudanças socioeconômicas e ambientais das famílias que sofreram com a recategorização do antigo Parque Estadual do Jacupiranga para a Reserva de Desenvolvimento Sustentável (RDS) dos Quilombos de Barra do Turvo e a Área de Proteção Ambiental (APA) do Planalto do Turvo, Mosaico de Jacupiranga/SP, onde a legislação ambiental permite a presença de moradores bem como suas atividades de subsistência. A coleta de dados foi feita pelo processo de entrevistas estruturadas realizadas com 12 moradores escolhidos por indicação dos próprios moradores das áreas tanto da APA quando da RDS. Com isso, pode-se observar uma maior liberdade nas atividades de uso da terra praticadas pelos moradores, contudo, mesmo com a recategorização, os investimentos públicos locais não são suficientes para propiciar uma boa qualidade de vida para as famílias das áreas analisadas

Análise da expressão protéica de moléculas de adesão celular em melanomas cutâneos

Cutaneous melanoma is a malignancy caused by the uncontrolled proliferation of melanocytes. Has been increasing in incidence and mortality over the years. This type of tumor may arise in the skin or any other place where there was migration of neural crest cells. Melanocytes are located in the basal layer of the epidermis forming the epidermal melanin unit, involving a melanocyte to 36 keratinocytes. The proliferation of melanocytes depends on this relationship with the keratinocytes, gap junctions, E-cadherin and desmoglein. The basal membrane is responsible for promoting the integrity of the skin, their adhesion structures shown to be altered in several skin diseases. Some molecules that play the role of adherence in this membrane are the laminins, type IV collagen and type XVII and perlecan. Analysis of protein expression of cell adhesion molecules in melanoma by immunohistochemistry on tissue microarray (TMA). We selected paraffin blocks of patients who were diagnosed with cutaneous melanoma in the period 1995 to 2010, reaching a sample of 124 cases. All these have gone through review of preparation for subsequent histological analysis of tissue microarray (TMA). The protein expression will be analyzed by immunohistochemistry, using markers anti-laminin, anti-collagen type IV and type XVII and anti-perlecan. There was a predominance of female patients, Caucasians and southeastern Brazil. There were frequent in type of extensive superficial ulcers with Breslow depth greater than 4 mm, Clark level IV and mitotic index greater than 6 mitoses per cga. The patients, most of them were female with mean age of 57.13 years and Caucasian. The most frequent histological type was extensive superficial followed by acral lentiginous. Predominated cases very deep, with Breslow thickness greater than 4 mm, Clark IV, ulcerated and on average by 9 cga mitosis, leading to worse prognosis in this sample. It...(Complete abstract click electronic access below)

Estudo sobre eficiência energética em uma unidade industrial

This work contemplates an opportunities study of the rational use of energy in an industrial unity from the demand analysis and electrical energy consumption. Through a guide of energy analysis it was described how to find the main problems that create energy wastes in an industry, showing the ways so the production processes avoid such wastes and start to use energy in a more sensible e efficient way. It was also studied, the technical e economical viability of possible interventions to be implemented in terms of energy conservation and of possible demand supply alternatives

Análise da expressão de antígenos câncer/testítulo (CTs) em pacientes com mieloma múltiplo

O mieloma múltiplo (MM) é uma neoplasia maligna secundária à expansão clonal de células plasmáticas caracterizada pela presença de imunoglobulina monoclonal no sangue e/ou na urina, lesões líticas ósseas e infiltração de plasmócitos monoclonais na medula óssea. A caracterização dos mecanismos responsáveis pela expansão das células tumorais do MM é difícil e envolve uma série de alterações genéticas e mudanças no microambiente da medula óssea, favorecendo o crescimento do tumor e a falha do sistema imune em reconhecê-lo. O MM é uma doença incurável, sendo a sobrevida mediana dos pacientes em torno de 3-5 anos. Terapias atuais como quimioterapia e transplante autólogo de células-tronco podem induzir remissão da doença, mas a recaída e a morte são inevitáveis. Os antígenos específicos câncer/testículo (CTs) foram originalmente descritos em pacientes com melanoma e são assim denominados, pois suas proteínas foram identificadas em espermatogônias, células conhecidas por não expressarem antígenos de histocompatibilidade (HLA), o que as impossibilita de desencadear uma resposta imune específica. Esses antígenos foram identificados posteriormente em vários tipos de tumores humanos, como melanoma, carcinoma pulmonar, câncer renal, entre outros. Até o momento, existem poucas informações a respeito de sua importância como fatores de prognóstico clínico ou relacionado à proliferação aberrante das células plasmáticas. Assim, o objetivo deste estudo é avaliar o nível de expressão gênica dos antígenos câncer/testículo MAGEC1(CT7), MAGEA3/6, LAGE-1, NY-ESO-1 e GAGE em amostras de aspirado de medula óssea total de pacientes com mieloma múltiplo. A análise de expressão por RT-PCR dos 5 CTs de interesse, realizada em 21 amostras de medula total de pacientes com MM, demonstrou as seguintes freqüências: CT7 (42,9%), LAGE-1 (23,8%)... (Resumo completo, clicar acesso eletrônico abaixo)

Análise retrospectiva e tendências do serviço de inspeção do estado de São Paulo

Pós-graduação em Medicina Veterinária - FCAV

Simulação geoestatística e classificação numérica para o delineamento de unidade de mapeamento de atributos e erosão do solo

Pós-graduação em Agronomia (Ciência do Solo) - FCAV

Envelhecimento ativo: um desafio para a equipe multidisciplinar e para as pessoas idosas frequentadoras da Unidade de Atenção ao Idoso (UAI), no município de Uberaba - MG

Pós-graduação em Serviço Social - FCHS