June 12, 1820 letter to Epaphras "Kibby[sic]" on Circular by Baltimore preachers in the M.E. Church

Handwritten letter from Timothy Merritt to Epaphras "Kibby [sic]" on a Circular published by local preachers of the Baltimore area. Letter dated 6/12/1820, Circular dated 5/20/1820. Both are on the subject of the changed protocols resulting from decisions made at a General Conference held just previous to publication, involving the installment of new preachers

Letter to Rev. Epaphras "Kible". 05/12/1801

Handwritten letter from T. Merritt to Rev. Epaphras "Kible[sic]" regarding the latter's desire for Merritt to take on his preaching circuit citing ailing health. Dated May 12, 1801.

Letter to nephew, 12/11/1868

Letter from Daniel Whedon to nephew, Daneil Avery Whedon. Dated December 11 1868.

Letter to D. A. Whedon. Pittsfield. July 12, 1844.

Letter from Daniel Denison Whedon to Daniel A. Whedon, his nephew.

IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC).

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by polyclonal B cell activation and by the production of anti-double-stranded (ds) DNA antibodies. Given the inhibitory effects of IL-12 on humoral immune responses, we investigated whether IL-12 displayed such an activity on in vitro immunoglobulin production by SLE PBMC. Spontaneous IgG, IgG1, IgG2, IgG3 and IgM antibody production was dramatically reduced by addition of IL-12. These results were confirmed by Elispot assays detecting IgG- and anti-dsDNA-secreting cells. While IL-6 and TNF titres measured in PBMC supernatants were not modified by addition of IL-12, interferon-gamma (IFN-gamma) titres were up-regulated and IL-10 production down-regulated. Since addition of IFN-gamma did not down-regulate immunoglobulin production and since the inhibitory activity of IL-12 on immunoglobulin synthesis was not suppressed by anti-IFN-gamma antibody, we concluded that the effect of IL-12 on immunoglobulin production was not mediated through IFN-gamma. Our data also argue against the possibility that down-regulation of endogenous IL-10 production was responsible for the effect of IL-12. Thus, inhibition of IL-10 production by IFN-gamma was not accompanied by inhibition of immunoglobulin production, and conversely, restoration of IL-10 production by anti-IFN-gamma antibody did not suppress the inhibitory activity exerted by IL-12 on immunoglobulin production. Taken together, our data indicate that reduction of excessive immunoglobulin and anti-dsDNA antibody production by lupus PBMC can be achieved in vitro by IL-12, independently of IFN-gamma and IL-10 modulation.

Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans.

Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004-2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1-3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32- 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR = 6.7; 95%CI = 1.6-27.8), compared to MTHFR A1298A noncarrier men (OR = 0.9; 95%CI = 0.24-3.92) (p-interaction = 0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings.

Induction of anti-myelin antibodies in EAE and their possible role in demyelination.

Experimental allergic encephalomyelitis is characterized by invasion of lymphocytes and macrophages into the central nervous system resulting in inflammation, edema, and demyelination. Sera from Lewis rats from 7-95 days after immunization with purified guinea pig CNS myelin were examined with respect to their ability to opsonize myelin. This was correlated with the appearance of antibody components and the relative amounts of antibody to myelin basic protein (MBP) and proteolipid protein (PLP). Sera from rats 10-95 days after immunization preincubated with purified myelin induced phagocytosis of myelin by cultured macrophages with the resulting production of cholesterol ester. This opsonization activity as measured by the percentage of cholesterol esterified reached a peak at 26-27 days after immunization but remained significantly elevated up to 95 days post-immunization compared to the activity of serum from the Freund's adjuvant-injected controls. Immunoblots of the sera revealed a gradual increase in antibody activity against myelin components. ELISA assays for MBP and PLP antibody showed a similar pattern. Antibody to galactocerebroside (GC) was not detected by immunostains nor by the ELISA assay. Areas of demyelination were observed histologically by luxol-fast blue stained spinal cords up to 60 days post-immunization. These results indicate that antibodies to myelin protein when given access to myelin through or within the blood brain barrier could initiate or enhance the phagocytic response by peripheral or resident macrophages.

Molecular dissociation of FHA-induced IL-10 and IL-12 secretion by human dendritic cells.

info:eu-repo/semantics/nonPublished

Role of the IL-10/IL-12 balance in the primary cellular immune response of infants to pertussis vaccines

info:eu-repo/semantics/nonPublished

Effects of different molecular forms of FHA on IL-10 and IL-12 secretions by human dendritic cells.

info:eu-repo/semantics/nonPublished

Con máquinas propias o con las del contratista : puntos de indiferencia a través de 12 años

p.235-240

Razonamiento inductivo de 12 alumnos de secundaria en la resolución de un problema matemático

En este trabajo se presenta el resultado obtenido del análisis de un proceso de razonamiento inductivo desarrollado por 12 estudiantes de secundaria en un contexto de resolución de problemas. Se plantea un problema, en el transcurso de una entrevista, que consiste en determinar el número máximo de regiones que se obtienen al trazar rectas sobre un plano. Durante la resolución del problema los estudiantes, y a través del dialogo con el entrevistador, han de explicar y justificar sus decisiones. Centrándonos en el trabajo de Pólya y en otras investigaciones previas relacionadas sobre este tema, se define un sistema de categorías mediante las cuales se organizan los datos para su análisis.

imátgenes 10, 11 y 12

Fue el último en poseerla quien, instantes antes de perderla para siempre y movido por una presunción ya del todo instintiva, bautizó la ciudad con el nombre de Memoria grafiando esa palabra en las fachadas de las avenidas. Presumió que en un futuro, muy lejano quizá pero alcanzable, y a pesar de los trazos ya inseguros de su escritura afectada, alguien podría leerla y recobrar la lucidez.