Letters and memorials of state, in the reigns of Queen Mary, Queen Elizabeth, King James, King Charles the First, part of the reign of King Charles the Second, and Oliver's usurpation.

Binder's title: Sidney's state letters.

Corpus Schwenckfeldianorum /

Editors: v. 1-5, C.D. Hartranft and others; v. 6-14, E.E.S. Johnson and others; v. 15-19, S.G. Schultz and A.S. Berky.

Examen de ingenios; or, The tryal of wits. Discovering the great difference of wits among men, and what sort of learning suits best with each genius.

Classified for chess: p. 196.

Il libro del cortegiano, nuovamente corretto ad uso nella gioventu'.

Pref. signed: P.R.

Reflexiones politico-consolatoriae, oder, Reiffliche Uberlegūgen derjenigen Widerwertigkeiten und Unglück welchen ein Politicus und vornehmer Weltmann ... underworffen ist ... /

The portrait, by Melchior Küssel, shows the author as chancellor of the Prince Bishop of Fulda at the age of 36; the text includes some charmingly human and humorous passages, with various anecdotes & instances, also a translation of the English letter of Sir Thomas More to his wife, 13 September, 1529.

Antonii Heringii ... Tractatvs de fideivssoribvs, in qvo ex ivre commvni, civili ac canonico, nec non variorvm ivris interpretum commentariis, ac consiliis, vt et diversis imperii Romani, Germanici aliorvmqve regnorvm ... constitutionibus, ordinationibus ... integra materia fideivssionvm, tam practicè quàm theoricè, iusta methodo, ac summatim est collecta & exposita. Additis nunc primùm tractatibus Hippolyti de Marsiliis, Gvlielmi a Cvneo, & Petri Santernae in eadem, & affini materia. Cum indicibvs.

Mode of access: Internet.

The structural and electrochemical consequences of hydrogenating Copper N2S2 Schiff base macrocycles

A series of cis and trans tetradentate copper macrocyclic complexes, of ring size fourteen - sixteen, which employ amine and thioether donor groups are reported. Apart from 5,6,15,16-bisbenzo-8,13-diaza-1,4-dithia-cyclohexadecane copper(I) (cis-[Cu(H4NbuSen)]+) all of the complexes are obtained in the copper(II) form. Crystallographic analysis shows that the copper(II) complexes all adopt a distorted planar geometry around the copper. In contrast, cis-[Cu(H4NbuSen)]+ is found to adopt a distorted tetrahedral geometry. The complexes were subjected to electrochemical analysis in water and acetonitrile. The effect of the solvent, positions of the donor atoms (cis/trans) on E1/2 is discussed as is the comparison of the electrochemical behaviour of these complexes with their parent Schiff base macrocycles.

The in vivo susceptibility of Leishmania donovani to sodium stibogluconate is drug specific and can be reversed by inhibiting glutathione biosynthesis

Resistance to pentavallent antimonial (Sb-v) agents such as sodium stibogluconate (SSG) is creating a major problem in the treatment of visceral leishmaniasis. In the present study the in vivo susceptibilities of Leishmania donovani strains, typed as SSG resistant (strain 200011) or SSG sensitive (strain 200016) on the basis of their responses to a single SSG dose of 300 mg of Sb-v/kg of body weight, to other antileishmanial drugs were determined. In addition, the role of glutathione in SSG resistance was investigated by determining the influence on SSG treatment of concomitant treatment with a nonionic surfactant vesicle formulation of buthionine sulfoximine (BSO), a specific inhibitor of the enzyme gamma-glutamylcysteine synthetase which is involved in glutathione biosynthesis, and SSG, on the efficacy of SSG treatment. L. donovani strains that were SSG resistant (strain 200011) and SSG sensitive (strain 200016) were equally susceptible to in vivo treatment with miltefosine, paromomycin and amphotericin B (Fungizone and AmBisome) formulations. Combined treatment with SSG and vesicular BSO significantly increased the in vivo efficacy of SSG against both the 200011 and the 200016 L. donovani strains. However, joint treatment that included high SSG doses was unexpectedly associated with toxicity. Measurement of glutathione levels in the spleens and livers of treated mice showed that the ability of the combined therapy to inhibit glutathione levels was also dependent on the SSG dose used and that the combined treatment exhibited organ-dependent effects. The SSG resistance exhibited by the L. donovani strains was not associated with cross-resistance to other classes of compounds and could be reversed by treatment with an inhibitor of glutathione biosynthesis, indicating that clinical resistance to antimonial drugs should not affect the antileishmanial efficacies of alternative drugs. In addition, it should be possible to identify a treatment regimen that could reverse antimony resistance.

Технологично подпомогнато редовно обучение по информатика – полезни практики

Доклад, поместен в сборника на Националната конференция "Образованието в информационното общество", Пловдив, май 2011 г.

Random distributed feedback Raman fiber laser operating in a 1.2 μm wavelength range

The random distributed feedback fiber laser operating via the stimulated Raman scattering and random distributed feedback based on the Rayleigh scattering is demonstrated in the 1.2 μm frequency band. The RDFB fiber laser generates at 1174 nm up to 2.4 W of output power with corresponding slope efficiency more than 30%. The output radiation has the spectral shape similar to the conventional Raman fiber lasers and spectral width less than 1.7 nm. © 2011 Pleiades Publishing, Ltd.

Trends for Meetings and Expositions Industry

During the last decade, the meetings and expositions industry has flourished, even as it has struggled to cope with difficult challenges. This is a taste of things to me. In the years ahead, the global population will continue to grow and change, science and technology will tighten their hold on business and society and the world will knit itself ever more tightly into a single market. As a result, both opportunities and trials will abound.

The Beacon, April 8, 2011

Vol. 22, Issue 34, 8 pages