926 resultados para histamine liberation


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Children perceive philosophy classes as space and time in which they can speak whatever they think and they like. ! at is a fact: philosophy classes for and with children open space to speak and to think. But there is a distance between speak and be heard out. Which kind of hearing is interesting in this type of class? Hearing assumes a real meeting between persons and this takes for granted that someone is also and essentially interested in the other’s thought . Such questions take us to have a problem with our concept of childhood. Recovering debates made by Walter Omar Kohan about childhood and temporality we try to connect the questions we indicate here and their meaning in the classes of philosophy for children keeping as our aim to the liberating possibility to children and teachers.

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The first diary written by a woman, Minha vida de menina brings a description of the ordinary daily live and the peaceful live of Diamantina, of the rural Minas Gerais. Helena Morley, a teenager of the end of 19th century, presents us from the crazy city, to issues of liberation of the slaves. The vision world of the young narrator also provides an idea of how the women role has changed in our society.

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In Brazil, the Catholic Church has an important role in the construction of citizenship, education and training the rural lower classes of the population. Studied in this article, this participation and contribution in the 60s, by highlighting the strong weighting would take the issue of land reform. The Catholic Church was a major player in unionization campaigns and basic education and suffered great tensions and internal conflicts that divide between those who sought the "liberation of the oppressed" and those who fought for reforms without changing the "social order". This paper recovers the trajectory of implementation of various programs of Catholic union formation and foundation of unions. We use historical methodology and retrieve the voice of the authors through interviews with trade unionists, lawyers, church authorities and militants popular.

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The Brazilian automotive industry has undergone profound changes during the 90’s decade, as a consequence of the market opening up through the liberation of automobile imports. The exposure of the Brazilian domestic market to competition with imported products of high quality and lower prices indicated the need for significant changes in those auto industries operating in this country, with the intention of making them competitive. To achieve these objectives management and production concepts were adopted, such as: the just-in-time philosophy; lean manufacturing; outsourcing; reengineering and increasing the rate of automation in both production and management systems. These changes helped to increase productivity and, in turn, reduced the level of employment in the sector, especially in activities where the required qualification levels were low. Despite this modernization, the Brazilian companies have committed themselves to meet the specific needs of the Brazilian market. The objective of this paper is to analyze and present manufacturing strategies from six manufacturers of automotive vehicles: Toyota in Japan, Fiat in Italy, Volkswagen in Brazil and Germany and General Motors in the U.S. and Brazil. The predominant method of research was from reviewing relevant literature, whereas the empirical data was analyzed qualitatively. The article seeks to identify the manufacturing strategies adopted by manufacturers located in the above countries, electing one automotive manufacturer to represent each country. The research demonstrated that the processes for production of automobiles in four plants located in, the U.S. (GM); Italy (Fiat); Japan (Toyota) and Germany (VW) are similar to those adopted in Brazilian industrial plants of the same companies (GM and VW), with differences of operations only in the business strategies adopted by each of them.

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Pós-graduação em História - FCHS

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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The article intends to articulate how the methodological proposal of Foucault, denominated genealogy, is applied to the field in which it emerged, considering that the proposal of this method appeared with the author’s study about the subject of the prisons. To apprehend the execution of the feathers in the contemporary epoch, we searched in Foucault’s theories the concepts of subjectivation processes, power relationships, discursive formations and dispositive. Starting from these concepts, we focused some practices and/or discursive formations of punishment and surveillance that happen at the present time to exemplify the form as the genealogical process raise an interlacement of subjects, information, appearances and disappearances that always obey to a normative logic. To unmask and to understand this logic can favor the liberation of manners of subjectivations crystallized in the punished people and in those ones that execute the punishment. Stiller, we question ourselves on which is the real function of the confinement, of the controls and, why not, if the paradigm of the modernity, the prison, had fail.

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The oral records, deprived of great rhetoric elaboration, mark the family accounts and the testimonies about remarkable and apparently minor particularities of grand conflicts, like the World War II. The oral memory fulfilled an important function of historical transmission, especially in handing on to written record the organization of testimonies, revealing personal memories in the form of letters, diaries and narratives, besides of integrating itself to several works of fiction. In the present work we present the value of former partigiani’s testimonies collected in the volume Io sono l’ultimo (I am the last one) as evocation and transmission of personal remembrances strongly linked to the conflict and as manifestations in the literary field as well. The valuing by descendants and fellow countrymen of a tradition of memory communication make the testimony of men and women that fought for the liberation of many Italian locations much more than fragmented reports when the interested reader in the memory of those that survived, integrated to the micro-history of the events, perceive its expressive logic. We explore both the meaning of witness adopted by Giorgio Agamben and the esthetical value of the traumatized voice in the perspective of Márcio Seligman-Silva.

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Pós-graduação em Ciências Sociais - FFC

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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We review evidence that Stem Cell Factor (SCF) plays an important role in the pathophysiology of asthma. SCF is produced by a wide variety of cells present in asthmatic lung, including mast cells and eosinophils. Its receptor, c-kit, is broadly expressed on mature mast cells and eosinophils. SCF promotes recruitment of mast cell progenitors into tissues, as well as their local maturation and activation. It also promotes eosinophil survival, maturation and functional activation. SCF enhances IgE-dependent release of mediators from mast cells, including histamine, leukotrienes, cytokines (TNF-alpha, IL-5, GM-CSF) and chemokines (RANTES/CCL5, MCP-1/CCL2, TARC/CCL17 e MDC/CCL22); it is required for IL-4 production in mast cells. SCF, acting in concert with IgE, also upregulates the expression and function of CC chemokine receptors in mast cells. Structural and resident airway cells express increased levels of SCF in the bronchus of asthmatic patients. In a murine model of asthma, allergen exposure increased production of SCF by epithelial cells and alveolar macrophages, which was transient and paralleled by histamine release. SCF induced long-lived airway hyperreactivity, which was prevented by local neutralization of SCF, as well as by inhibitors of the production or activity of cysteinyl-leukotrienes. Together, these observations suggest that SCF has an important role in asthma.

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There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines. Plasma inflammatory cytokines (IL-1β, -6, -8, -10, -12, TNF-α) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer Our findings suggest an increase of the pro-inflammatory IL-8 (p < 0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Ciências Sociais - FCLAR