Subregional preparations for the 2004 international meeting that will undertake a full and comprehensive review of the implementation of the SIDS POA to ensure the most effective participation of Caribbean SIDS

In Part XV (Implementation Monitoring and Review);, of the Programme of Action of Small Island Developing States (SIDS POA);, which was adopted at the United Nations Global Conference on the Sustainable Development of Small Island Developing States (UNGCSIDS);, 26 April- 6 May 1994, in its paragraph 117, it is provided that the Commission on Sustainable Development (CSD); should, inter alia: Carry out an initial review of the progress achieved and steps taken to implement the Programme of Action, to be undertaken by the Commission on Sustainable Development in 1996 in accordance with its Multi-Year Thematic Programme of Work. Furthermore, in 1997, when the Commission will carry out the overall review of Agenda 21 with a view to preparing for the 1997 special session of the General Assembly, the Commission should recommend specific modalities for the full review of the Programme of Action in 1999. That full review would include the question of the convening of a second global conference in accordance with chapter 17, Section G of Agenda 21. At the twenty-second special session which convened on 27-28 September 1999 to undertake a "review and appraisal of the implementation of the Programme of Action for the Sustainable Development of Small Island Developing States", it was recommended, inter alia, that: "Although periodic reviews of certain aspects of the Programme of Action are envisaged within the context of the work of the Commission on Sustainable Development, a full and comprehensive review of these decisions and the implementation of the Programme of Action would be useful and required in 2004." In the Plan of Implementation adopted at the World Summit on Sustainable Development (WSSD);, which convened in Johannesburg, South Africa, over the period, 26 August-4 Septemeber 2002, the relevant recommendation was as follows: "Undertake a full and comprehensive review of the implementation of the Barbados Programme of Action for the Sustainable Development of Small Island Developing States in 2004, in accordance with the provisions set forth in General Assembly resolution S-22/2, and in this context requests the General Assembly at its fifty-seventh session to consider convening an international meeting for the sustainable development of small island developing States."

International experiences with comprehensive and effective road safety campaigns

This issue of the FAL bulletin analyses the main characteristics of public policy and of the design of road safety campaigns, using six international (Latin American and European) experiences.

Tocantins river as an effective barrier to gene flow in Saguinus niger populations

The Saguinus represent the basal genus of the Callitrichinae subfamily. Traditionally this genus is divided into three groups: Hairy, Mottled and Bare-face, however, molecular data failed to validate these groups as monophyletic units, as well as raised some subspecies to the species status. This is the case of the former subspecies Saguinus midas midas and S. midas niger, which are now considered as different species. In the present study, we sequenced a portion of the D-loop mtDNA region in populations from the East bank of the Xingu and from both banks of the Tocantins river, in order to test the effectiveness of large rivers as barriers to the gene flow in Saguinus. According to our results, the populations from the East and West banks of the Tocantins river are more divergent than true species like S. mystax and S. imperator. The Tocantins river may be acting as a barrier to gene flow, and consequently these very divergent populations may represent distinct taxonomic entities (species?).

Effective Use of Alteplase for Occluded Tunneled Venous Catheter in Hemodialysis Patients

Despite their propensity for significant infectious and mechanical complications, tunneled central venous catheters (CVCs) have become a common means of vascular access in the world for patients requiring chronic hemodialysis for end-stage renal disease. The objective of this study was to explore if cryopreserved solutions of the thrombolytic agent alteplase could be used as an effective, safe, and economically reasonable alternative in hemodialysis patients with occluded tunneled CVC. Patients requiring chronic hemodialysis and presenting with occluded tunneled CVC received a sufficient volume of the alteplase solution to fill the occluded catheter. To make alteplase economically feasible, it was diluted to 1-mg/mL aliquots and they were stored at -20 degrees C until use. Eighty-one patients accounting for 179 attempted clearances were assessable for efficacy. One hundred forty-seven (82.1%) of the 179 catheter clearance attempts resulted in successful catheter clearance after one dose. Twenty-seven (15.1%) of all occluded CVCs were successful after two doses whereas five (2.8%) were not. No adverse events were reported. Cryopreserved 1-mg/mL aliquots of alteplase are safe and effective in the clearance of occluded CVC for hemodialysis patients.

Study of pK Values and Effective Dielectric Constants of Ionizable Residues in Pentapeptides and in Staphylococcal Nuclease (SNase) Using a Mean-Field Approach

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Effective tooth-bleaching protocols capable of reducing H2O2 diffusion through enamel and dentine

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Production of the First Effective Hyperimmune Equine Serum Antivenom against Africanized Bees

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

3D stability orbits close to 433 Eros using an effective polyhedral model method

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Inbreeding, Average Relatedness Coefficient and Effective Population Size In Jaffarabadi Buffaloes Raised In Brazil

The major aim of this study was to evaluate the inbreeding (F), average relatedness coefficient (AR) and effective population size (Ne) in the Jaffarabadi buffalo breed from Brazil. Pedigree information of 1,272 animals born from 1966 was used. The effective population size was calculated in two ways: first, computed via individual increase in inbreeding and second estimated by individual increase in coancestry. The known generation numbers were 1.24, 1.76 and 2.64 for complete, equivalent and maximum generation, respectively. The effective size computed via individual increase in coancestry was small with a value of 10.82 +/- 1.29. The effective size computed by individual increase in inbreeding (10.40 +/- 3.69) was very similar but a little smaller than the previous reported value. The average values of F and AR for the population reference (1,059) were 4.22 and 12.5 percent. The mean of F for inbred animals (319) was 14.0%. The F and AR means were 5.7 and 13.3% for animals with at least 1.5 known equivalent generation and 9.3 and 15.97% for individuals having at least 2.5 equivalent generations known. It was found 78 matings between half sibs (6.14%) and 67 matings (5.27%) between parent-offspring. The estimated inbreeding increase per generation by considering maximum generation, complete generation and equivalent generation were 1.21%, 5.18% and 3.57%, respectively. Considering the uncompleted pedigree, the estimated inbreeding for the reference population could be underestimated.