School of Nursing Class of 1997

Top Row: Shelly Adkins, Nikki Alexadner, Amy L. Ancona, Adem Arslani, Noel Baldwin, Lea Bell, Michelle Bellah, Nicole Bills, Sarah Boyle, Rebekah Brandstatter, Margitt Brigant, Matthew Brooks, Julie Campbell, Lea Clemmons

Row 2: Iracema M. Crawford, Amy Decker, Danielle Terry, Jennifer McGeown, Megan Lindsey Tvaska, Molly McIntyre, Sharon M. Hoover, Mary Beth Pohanka, Jennifer Nelson, Jennifer Carney, Katheryn E. Huffman, Toria Dial, Mary Dooley

Row 3: Pamela Earl, Stacy Ekelman, Jennfier Emery, Robert Farrell, Stephanie R. Faudel, Amy Fischer, Rochelle Fountain, Diane Fox

Row 4: Tina Garcia, Monica Gatica, Meredith Giles, Karla Giminez, Emily Goodsell, Barbara Gurd, Keren Kay Hahn, Beth Hosmer, Shana N. Howard, Cina Jackson-Hanner

Row 5: Kristy Jakubiak, Rebekah Johnson, Stephanie T. Johnson, Jennifer Jorissen, Richard W. Redman, Beverly Jones, Ada Sue Hinshaw, Nola Pender, Susan Boehm, Renee Kaplan, Angela Kendrick-Newing, Emily Kerschbaum, Donulae Knuckles

Row 6: Diane Kramer, Alyce Krause, Krista L. Kuczewski, Lori LaCrone, Melissa E. Lorencen, Sarah Lyons, Melissa Magante, Kathleen Mahon, Christy Mayes, Joseph Morris, Elizabeth Morrow, Tamala Myers, Michele Nextico

Row 7: Jacquelyn Nino, Denise Noto, Catherine Orser, Elizabeth Palad, Ann Peterson, Joshua Pietsch, Pati Putt, Lisa Reinhart, Jamie C. Renken, Amy Robbins, Ernest Saxton, Amy Schafer, Joelle Schroeder, Matthew Seiler

Row 8: Sarah Bellestri Shih, Kristen Sisson, Shalonda Smith, Kathleen Stewart, Jeannine Sutter, Jamie Swan, Arita Ann Sywenkyj, Julie Talbott, Diana Thorrez, Natasha Tokarz, Whitney Tonkin, Rea Tsatsanifos, Tina Urbanski

Row 9: Maricar Uy, Dana Van Singel, Tanya D. Venton, Christina Vitucci, Samuel Walsh, Susan Warren, Tiana Washington, Yvette White, Judy M. Wilson, Cerise Wotorson, Bella Yagolkovskaya, Karen Zalenko, Susan M. Zucal

School of Nursing Class of 2001

Top Row: Cher Alaniz-Dowling, Katie Anibal, Tasneem Ba, Ethel Balaoing, Melissa Balok, Kristen Begin, Hillary bertke, Bess Bertolis, Lauren Blitz, roberta Bolio, Mariana Bordei, Christa Brock, Brianna Burg

Row 2: Kara Calhoun, Erin champieux, Sarah Marshall, Trevor Finton, Leovigildo Olivarez, Dena Fernandez, Daniel J. Tounsel, Emily Schmitt, Bridget Lufkin, Jessica Witt, Ryan VanLoocke, Quanda Chen, Vivian Cheng, Kelly Chiles

Row 3: Alicia Classens, Kristin coil, Michelle Crist, Jeremy Curtis, Shannon Dabao, Melanie Datu, Amanda Dean, Pina Desai, Theresa De Sitter, Kathryn DeWitt

Row 4: Elizabeth Dorda, Laura Dow, Jennifer Feighner, Elizabeth Findley, Katherine Fix, Lindsy Gasparovich, Michelle Gastman, Silvia Gonzafez, Cari Gray, Elizabeth Handzlik

Row 5: Lauren Hisey, Karen Hofmeister, Patricia M. Holda, Jennifer Hoskins, Emily Jacobson, Rita Jiddou, Elisabeth Jilek, Patrielle R. Johnson, Susanna Johnston, Kelly Kandt, Kelly Kazup, Sara Kile

Row 6: Lisa Kuzma, karen Kwapis, Tracey Lee, Patricia Coleman-Burns, Nola Pender, Carol Loveland-Cherry, Ada Sue Hinshaw, Beverly Jones, judith Lynch-Sauer, Jan L.Lee, Kimberly Little, Amber Manchester, Tracie Martinez

Row 7: Brenda K. Maynard, Molly McCormick, Christopher McWatters, Kirsten Meister, Dorota Meller, Kevin Michel, Emily Mulla, Geine Nolan, kelly Noyes, Brandi Otto, Alice Palmer, Tricia Pasaoa, Erika Pete, Rebekah Peterson, Menusa Petrovski

Row 8: Jacqueline pinson, Gretchen Pletz, Rachelle Ramos, Rochelle E. Ramos, Rebecca Roberts, Darice Rosario, Andrea Ryan, Clare Ryan, Jason schwartz, Andrea Sears, Sarah Skavnak, Elizabeth Slager, Sara Smith, Dana Sullivan

Row 9: Allison Sweet, Irie Thom, Charly R. Thomas, Michelle Thurman, Shamin Ullah, Kellie Vaidya, Cynthia Valerio, Erin Verkerke, Kristen Verska, Winderence Webb, Marisa Wheatley, Kristine Wiersma, Monique D. Williams, Katherine Willis, Jennifer Zelle

School of Nursing Class of 2006

Top Row: Rebecca Adams, Leslie Babich, Katherine Banas, Lori Barnett, Stacey Bednarz, Kelly C Berryman, Adam Brieger, Tina Brown, Kimberly Burleigh, Anne Byrne, Julia Carl, Terra Caswell, Angela Chabot, Molly Colgan, Desiree Conyers, Amy Cook, Melissa Cooley, Ashley Cooper, Morgan Cornell

Row 2: Delphine Cornet, Laura Cortina, Casey Cox, Bradley Crow, Lauren D'Agostino, Katelyn Davis, Kara Dendrinos, Rachael Dunckel, Carolyn Ellis, Kristin Ellis

Row 3: Deonna French, Erin Gasser, Amanda George, Michelle Gilmore, Jacquelene Goyett, LaRonda Gracia, Tera Greenberg, Tracy Guzzardo, Amy Hamlin Tapper, Shawn Hathaway

Row 4: Jennifer Heller, Michele Hetfield, Hilary Heuer, Christen Hicks, unknown, Melissa Jenkins, Terri Jobkar, Jennifer Keller, Karissa Kerg, Katherine Kern

Row 5: Keri Kingma, Amanda Kristofik, Brigid Kutner, Melissa LaDuke, Lorraine Law, Katherine Lawler, Allison Ledtke, Corinne Lee

Row 6: Kerrie Lemerand, Kristen Maki, Smith Margaret, Cynthia Mathew, Thomas Mazzocco, Cara McAlpin

Row 7: Lana McCarthy, Erin McKeever, Nicolyn Meek, Patricia Coleman-Burns, Carol Loveland-Cherry, Judith Lynch-Sauer, Ada Sue Hinshaw, Barbara Guthrie, Marge Calarco, Carolyn Sampeselle, Joanne Pohl, Therese Messing, Rachel Milkowski, Renee Miller

Row 8: Andrea S Miller, Stephanie Mizer, Melissa Morgan, Heather Bidgoli, Elisa Brunetto, Jessica Cleghorn, Jade Curry, Ashley Dorow, Megan Finn, Lisa Gruen, Margaret Kelemen, Andrea Munger, Elizabeth Spencer, Mary Vanderweele, Abigail Vertalka, Jackelyn Ng, Phuong Nguyen, Gracia Nicolaescu

Row 9: Laura Norris, Elizabeth Osborn, Lavinia Pacurar, Carly Palmer, Kristine Parish, Jill Patterson, Mary Pepper, David Perout, Michael Pfeifer, Kristin Phillips, Susanne Pickman, Vanessa Polly, Sabrina Porter, Christina Quillan, Lauren Ramoie, Natasha Rivers, Teresa Roberts, Megan Robertson, Byanqa Robinson

Row 10: Mary Rodzik, Kimberly Sanders, Weber Sasha, Rebecca Scheiblauer, Taylor Schmidt, Jacquelyn Schrot, Tanya Shisler, Daniel Shivel, Sophia Shyu, Michelle Skurulsky, Melissa Smalligan, Erin Sorensen, Allison Spinweber, Lindsay Steiger, Natalya Stokely, Karen Stoneburner, Katherine Stout, Stephanie Swihart, Aaron Taylor

Row 11: Lori Thome, Christopher Thuer, Carolyn Trabka, Kathryn Trommbley, Valerie Tumbleson, Stacey Ventola, Dana Verkade, Caitlyn Vert, Angela Videto, Kari Wanless, Abby Wegener, Stephanie Westphal, Eric Williams, Whitney Zachritz, Amber Zemer, Joanna Zizzo, Chelsea Zussman

School of Nursing Class of 2009

Top Row: Allison Anderson, Meghan Archer, Christopher Aten, Meredith Bajor, Sarah Belleville, Kimberly Bergere, Courtney Bernier, Diana Blanks, Julie Bluhm, Melanie Bork, Karyn Braley, Kathryn Melody Briones, Christine Brouillard, Alyson Bryson

Row 2: Amy Burk, Kelly Capellari, Carmon Carlson, Krystal Cavaliere, Jeffrey Chiambretti, Christine Cho, Renee Christopher, Holli Clewis, James Conway, Kelly Courtney, Jenna Dahn, Erin Daly, Nicole DeFauw, Stefanie DeVita, Jessica DiVirgil, Debra Dombrowski, Genevieve Donnell

Row 3: Kathleen Donnelly, Jennifer El Aile, William Faulkner, Kimberly Johnson, Danielle Alameda, Margaret Wheeler, Brian D Kaminski Jr, Bridget Fil, Rochelle Weller, Leslie Allen-Huisman, Jennifer Musbach, Kathy Feig, Lori Fellows, Shana Ferguson

Row 4: Lauren Frawley, Ashton Frederick, Molly Gacetta, Stephanie Ganger, Amanda Garcia, Megan Gdowski, Chad Godfrey, Emily Halpern

Row 5: Katherine Hammons, Natalie Hecht, Danielle Hiltz, Taylor Hosner, Jennifer Huber, Holly Huling, Nathaniel Hunt, Ana-Leonor Jay

Row 6: Rachel Jeltema, Jennifer Jones, Lindsey Jones, Sarah Kaherl, Jessica Kehbein, Kendra Leidecker, Vanessa Lelli, Meghan Lemmer, Rachel Levinson, Alexandra Lindsay

Row 7: Amanda MacDonald, Joelle Marineau, Laura Mason, Andrea Masser, Michele McKinney, Charles-Robert Moultry, Kathleen Potempa, Bonnie Hagerty, Nicole Nader, Minna Navvab, Rachael Newnam, Uche Obua, Sara Oles, Ceren Onsan-Fitzpatrick

Row 8: Emily Parobek, Dorasy Paul, Rosalynne Pinga, Sarah Pope, Laura Randall, Sarah Reits, Emma Rew, Annemarie Rozwadowski, Nicole Ruhlman, Lydia Sanok, Grace Savercool, Kimberly Schmidt, Renee Schoenborn, Lisa Schuman, Kaitlyn Seltzer, Catherine Sherwood, Elizabeth Smith

Row 9: Aimee Surma, Stephanie Swinteck, Hanna Taylor, Donnie Tietsema, Andreea Toader, Stephanie Upplegger, Meghan Visnick, Scharnice Ward, Tabytha Whitley, Kimberly Wilke, Carie Wright, Kyleen Young, Kristin Zawacki, Christina Ziegler, Carlotta Zirker

Junior Law Class of the U of M, 1886-1887 [standing on steps to Law Department]

(Mrs. L.D. Groves, Views of Ann Arbor)

Changes in funded debt and fixed and contingent charges of class 1 steam railways and their lessors during 1942, excluding railways in receivership or trusteeship ...

At head of title: Interstate commerce commission. Bureau of transport economics and statistics.

Bergey's manual of determinative bacteriology; a key for the identification of organisms of the class Schizomycetes,

Mode of access: Internet.

Regulation of dendrite growth, placement, and patterning in Drosophila melanogaster class 4 dendrite arborization neurons

Thesis (Ph.D.)--University of Washington, 2016-06

A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug

Relatively few cyclic peptides have reached the pharmaceutical marketplace during the past decade, most produced through fermentation rather than made synthetically. Generally, this class of compounds is synthesized for research purposes on milligram scales by solid-phase methods, but if the potential of macrocyclic peptidomimetics is to be realized, low-cost larger scale solution-phase syntheses need to be devised and optimized to provide sufficient quantities for preclinical, clinical, and commercial uses. Here, we describe a cheap, medium-scale, solution-phase synthesis of the first reported highly potent, selective, and orally active antagonist of the human C5a receptor. This compound, Ac-Phe[Orn-Pro-D-Cha-Trp-Arg], known as 3D53, is a macrocyclic peptidomimetic of the human plasma protein C5a and displays excellent antiinflammatory activity in numerous animal models of human disease. In a convergent approach, two tripeptide fragments Ac-Phe-Orn-(Boc)-Pro-OH and H-D-Cha-Trp(For)-Arg-OEt were first prepared by high-yielding solution-phase couplings using a mixed anhydride method before coupling them to give a linear hexapeptide which, after deprotection, was obtained in 38% overall yield from the commercially available amino acids. Cyclization in solution using BOP reagent gave the antagonist in 33% yield (13% overall) after HPLC purification. Significant features of the synthesis were that the Arg side chain was left unprotected throughout, the component Boe-D-Cha-OH was obtained very efficiently via hydrogenation Of D-Phe with PtO2 in TFA/water, the tripeptides were coupled at the Pro-Cha junction to minimize racemization via the oxazolone pathway, and the entire synthesis was carried out without purification of any intermediates. The target cyclic product was purified (>97%) by reversed-phase HPLC. This convergent synthesis with minimal use of protecting groups allowed batches of 50100 g to be prepared efficiently in high yield using standard laboratory equipment. This type of procedure should be useful for making even larger quantities of this and other macrocyclic peptidomimetic drugs.

Potent T cell response to a class I-binding 13-mer viral epitope and the influence of HLA micropolymorphism in controlling epitope length

The BZLF1 antigen of Epstein-Barr virus includes three overlapping sequences of different lengths that conform to the binding motif of human leukocyte antigen (HLA) B*3501. These 9-mer ((56)LPOGQLTAy(64)), 11-mer ((54)EPLPQGQLTAy(64)), and 13-mer ((52)LPEPLPQGQLTAY(64)) peptides all bound well to B*3501; however, the CTL response in individuals expressing this HILA allele was directed strongly and exclusively towards the 11-mer peptide. In contrast, EBV-exposed donors expressing HLA B*3503 showed no significant CTL response to these peptides because the single amino acid difference between B*3501 and B*3503 within the F pocket inhibited HLA binding by these peptides. The extraordinarily long 13-mer peptide was the target for the CTL response in individuals expressing B*3508, which differs from B*3501 at a single position within the D pocket (B*3501, 156 Leucine; B*3508, 156 Arginine). This minor difference was shown to enhance binding of the 13-mer peptide, presumably through a stabilizing interaction between the negatively charged glutamate at position 3 of the peptide and the positively charged arginine at HLA position 156. The 13-mer epitope defined in this study represents the longest class I-binding viral epitope identified to date as a minimal determinant. Furthermore, the potency of the response indicates that peptides of this length do not present a major structural barrier to CTL recognition.

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling

The interactions between Eph receptor tyrosine kinases and their ephrin ligands regulate cell migration and axon pathfinding. The EphA receptors are generally thought to become activated by ephrin-A ligands, whereas the EphB receptors interact with ephrin-B ligands. Here we show that two of the most widely studied of these molecules, EphB2 and ephrin-A5, which have never been described to interact with each other, do in fact bind one another with high affinity. Exposure of EphB2-expressing cells to ephrin-A5 leads to receptor clustering, autophosphorylation and initiation of downstream signaling. Ephrin-A5 induces EphB2-mediated growth cone collapse and neurite retraction in a model system. We further show, using X-ray crystallography, that the ephrin-A5-EphB2 complex is a heterodimer and is architecturally distinct from the tetrameric EphB2-ephrin-B2 structure. The structural data reveal the molecular basis for EphB2-ephrin-A5 signaling and provide a framework for understanding the complexities of functional interactions and crosstalk between A- and B-subclass Eph receptors and ephrins.

Embracing ligands. Synthesis, characterisation and the correlation between 59Co NMR and ligand field parameters of Co(III) complexes with a new class of nitrogen-thioether multidentate ligand

The syntheses of the hexadentate ligands 2,2,10,10-tetra(methyleneamine)-4,8-dithiaundecane (PrN(4)S(2)amp), 2,2,11,11-tetra(methyleneamine)-4,9-dithiadodecane (BuN(4)S(2)amp), and 1,2-bis(4,4-methyleneamine)-2-thiapentyl)benzene (XyN(4)S(2)amp) are reported and the complexes [Co(RN(4)S(2)amp)](3+) (R = Pr, Bu, Xy) characterised by single crystal X-ray study. The low-temperature (11 K) absorption spectra have been measured in Nafion films. From the observed positions of both spin-allowed (1)A(1g) --> T-1(1g) and (1)A(1g) --> T-1(2g) and spin forbidden (1)A(1g) --> T-3(1g) and (1)A(1g) --> T-3(2g) bands, octahedral ligand-field parameters (10D(q), B and C) have been determined. DFT calculations suggest that significant interaction between the d-d and CT excitations occurs for the complexes. The calculations offer an explanation for the observed deviations from linearity of the relationship between Co-59 magnetogyric ratio and beta(DeltaE)(-1) (beta = the nephelauxetic ratio; DeltaE the energy of the (1)A(1g) --> T-1(1g) transition) for a series of amine and mixed amine/thioether donor complexes.