985 resultados para William P. Whelihan III


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One letter regarding payment of a balance by a Mendoza, possibly related to the Chanca silver mine.

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This folder contains transcriptions of archival materials used in Lane's research for the article, published by the Colonial Society of Massachusetts in 1923. Included are two letters from the papers of Harvard President Jared Sparks (1849-1853) regarding the christening basin and the role of the College steward in the care of the silver collection; and a 1781 inventory (see also in folder 7) and 1829 Corporation vote excerpted from College records. There are also two notes containing citations.

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Sterile immunity against malaria can be achieved by the induction of IFNgamma-producing CD8(+) T cells that target infected hepatocytes presenting epitopes of the circumsporozoite protein (CSP). In the present study we evaluate the protective efficacy of a heterologous prime/boost immunization protocol based on the delivery of the CD8(+) epitope of Plasmodium berghei CSP into the MHC class I presentation pathway, by either a type III secretion system of live recombinant Salmonella and/or by direct translocation of a recombinant Bordetella adenylate cyclase toxoid fusion (ACT-CSP) into the cytosol of professional antigen-presenting cells (APCs). A single intraperitoneal application of the recombinant ACT-CSP toxoid, as well as a single oral immunization with the Salmonella vaccine, induced a specific CD8(+) T cell response, which however conferred only a partial protection on mice against a subsequent sporozoite challenge. In contrast, a heterologous prime/boost vaccination with the live Salmonella followed by ACT-CSP led to a significant enhancement of the CSP-specific T cell response and induced complete protection in all vaccinated mice.

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National Highway Traffic Safety Administration, Washington, D.C.

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Vols.[1-4] edited by William John Hardy; v.[5-6] by Edward Bateson.

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Mode of access: Internet.