Urban ecology of Triatoma infestans in San Juan, Argentina

This study was performed in an urban neighborhood of the capital city of the province of San Juan, Argentina. Erected as a housing complex, the place consists of 768 flats distributed in buildings of three and seven floors each. A survey was carried out in 33% of the dwellings, enquiring about the number of Triatoma infestans found indoors, stage of the bug development - nymph or adult - and how these insects had entered their homes. Adult T.infestans were found on all floors; 163 people (64%) had found them at least once, and 130 (51%) several times. Dispersal flight seems to have been the main mechanism of infestation by adult bugs in this area, and a total of 51% of the surveyed inhabitants reported that the insects had flown into their flats.

Business plan: PARQUETS, S.A.

Aquest Treball Final de Carrera pretén desenvolupar un Pla de Viabilitat, que garanteixi una millora en la rendibilitat de PARQUETS S.A., una empresa amb més de 40 anys d’existència en el sector de la instal-lació de paviments per al terra. A partir de la realització inicial d’un estudi del mercat, s’ha elaborat un complet anàlisi sobre els punts principals que componen qualsevol Pla de Negoci: el Pla de Marketing, el Pla d’Operacions, el Pla d’Organització i el Pla Econòmic-Financer. A més, amb la realització d’aquest estudi, hem pogut verificar que al mercat hi ha importants economies d’escala que cal aprofitar, i que intervindrien amb èxit amb l’expansió geogràfica, organitzativa i operativa de l’empresa.

El proceso de sucesión en la empresa familiar

La majoria dels experts coincideixen en definir l’empresa familiar com l’empresa a la que el capital, la gestió y el govern estan en mans de una o mes famílies que exerceixen control sobre ella. El punt mes important que diferencia l’empresa familiar de la no familiar es el propòsit de la continuïtat, que es dona en a les empreses familiars, a través de l’entrada de les successives generacions. Aquesta continuïtat es materialitza amb l’èxit del procés successori que dona lloc a la nova generació. La complexitat d’aquest tipus d’empreses deriva de la unió de les dos entitats que la formen, empresa i família. Aquesta unió suposa la combinació d’assumptes purament empresarials amb altres de caràcter més personal. La unió de tots dos interessos dins de l’empresa suposa una important font de conflictes i problemes per a l’organització. A mesura que la família es fa més gran els problemes també creixen, i les relacions entre la família i la empresa es fan més difícils i complicades. Es per això que l’empresa ha d’actuar amb temps i avançar-se a les futures dificultats que puguin presentar-se a l’organització, tractant d’evitar-les, fent servir les eines de que disposa. Per assegurar el èxit del procés successori i evitar futurs problemes interns, l’empresa, i sobretot el predecessor, han de manejar i definir de forma correcta el marc legal i el marc familiar que emmarquen les seves relacions. En primer lloc, el marc legal ha d’assegurar la bona comunicació entre la família i l’empresa, per així, evitar futurs malentesos. A través d’òrgans com el Consell d’Administració i la Junta General d’Accionistes l’empresa reforça aspectes com la unitat i el compromís, que son tan necessaris en moments de canvi generacional. Per una altra banda, el marc familiar ha de vetllar pel manteniment dels valors propis de la família que el predecessor ha inculcat al llarg dels anys, i que han servit de guia tant a l’empresa com a la família. El marc familiar el defineixen eines com el Protocol Familiar, que regula i gestiona les relacions entre la família, l’empresa i els propietaris de la organització. El òrgan encarregat de controlar el compliment d’allò pactat en el Protocol i d’encarregar-se del bon funcionament del marc familiar es el Consell de Família.

Reducció de despeses ineficients i sostenibilitat de l'Estat del Benestar: el cas de Catalunya

Malgrat que el debat de l’Estat del Benestar està en el bell mig de l’actualitat política i econòmica des de fa uns quants anys amb graus ben diversos i aproximacions diferents, la darrera gran crisi ha disparat com mai la seva actualitat. Fins el present moment, amb algunes notables excepcions, totes les tendències han conduit a desenvolupar l’Estat del Benestar fins a extrems insostenibles. Això té explicacions múltiples i variades com les que s’aborden al llarg del present text. Aquestes tendències tenen una dinàmica econòmica i social pròpia que s’ha constatat amb força durant els darrers anys. Fa unes dues dècades que aquest debat va ser encetat amb profunditat per pocs països, però amb conclusions estimulants. Suècia és l’exemple més reeixit. La reforma duta a terme en el país nòrdics és una referència de primer ordre per molts estudiosos del tema i hauria de ser font d’inspiració per a la resta de països. Seguidament, hem volgut descriure, de forma complementària i des d’una perspectiva econòmica i jurídica, un fenomen estrictament lligat al desenvolupament imparable de l’Estat del Benestar, el de la burocratització. La reflexió d’acadèmics d’escoles en diferents i, en particular, els de la Public Choice proporcionen una visió rica i complexa, que entenem fonamental per avaluar els problemes que se’n deriven. Finalment, dins el marc de la Hisenda Pública i entrant en l’estudi concret del cas català, hem volgut endinsar-nos en l’anàlisi del pressupost. Essent com és una eina indispensable per avaluar el conjunt de polítiques econòmiques i socials d’un país. Aquesta anàlisi es duu a terme des d’una doble perspectiva: la primera, mitjançant un estudi comparatiu de l’evolució del Pressupost de la Generalitat dels darrers anys i, en segon terme, el canvi que el Pressupost 2011 materialitza aquest any, prefigura el de l’any 2012 i les principals crítiques de l’oposició. Queden oberts els camins envers els possibles canvis. De fet, res està definitivament escrit, però la pretensió d’aquest treball és modesta i, alhora, clara. Sense embuts, si volem mantenir un grau de benestar sostenible, és fonamental deixar de banda l’actual concepció de l’Estat del Benestar i començar a treballar per implementar els profunds canvis necessaris que donin pas a l’únic model que, a parer nostre, aconseguirà que això sigui possible: la Societat del Benestar. Una concepció actual del paper que ha de tenir l’Estat, de caràcter liberal i, alhora, social.

Population dynamics of intermediate snail hosts of Fasciola hepatica and some environmental factors in San Juan y Martinez municipality, Cuba

The variation of abundances of intermediate snail hosts of Fasciola hepatica in Cuba (Fossaria cubensis and Pseudosuccinea columella) was studied during one year under natural conditions at five sampling sites in San Juan y Martinez municipality, Pinar del Rio province, Cuba. The effect of some environmental variables on the lymnaeid abundances was also studied. A canonical correspondence analysis showed that both species do not generally occur together in the same habitat and that most factors affect them in an opposite fashion, although both of them correlate positively through time to the diversity of the habitats. F. cubensis prefers the sites that are in or closer to the city whereas P. columella is more abundant in rural sites. Lymnaeid abundances are mainly affected by nitrite and nitrate concentrations as well as by the abundance of the thiarid Tarebia granifera. F. cubensis is more abundant in polluted habitats with low densities (or absence) of T. granifera whereas P. columella prefers cleaner habitats and can coexist with the thiarid, even at its higher densities. The implications of divergent preferences of the two lymnaeids for the control of fasciolosis are discussed.

Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease.

In Huntington's disease (HD), the expansion of polyglutamine (polyQ) repeats at the N terminus of the ubiquitous protein huntingtin (htt) leads to neurodegeneration in specific brain areas. Neurons degenerating in HD develop synaptic dysfunctions. However, it is unknown whether mutant htt impacts synaptic function in general. To investigate that, we have focused on the nerve terminals of motor neurons that typically do not degenerate in HD. Here, we have studied synaptic transmission at the neuromuscular junction of transgenic mice expressing a mutant form of htt (R6/1 mice). We have found that the size and frequency of miniature endplate potentials are similar in R6/1 and control mice. In contrast, the amplitude of evoked endplate potentials in R6/1 mice is increased compared to controls. Consistent with a presynaptic increase of release probability, synaptic depression under high-frequency stimulation is higher in R6/1 mice. In addition, no changes were detected in the size and dynamics of the recycling synaptic vesicle pool. Moreover, we have found increased amounts of the synaptic vesicle proteins synaptobrevin 1,2/VAMP 1,2 and cysteine string protein-α, and the SNARE protein SNAP-25, concomitant with normal levels of other synaptic vesicle markers. Our results reveal that the transgenic expression of a mutant form of htt leads to an unexpected gain of synaptic function. That phenotype is likely not secondary to neurodegeneration and might be due to a primary deregulation in synaptic protein levels. Our findings could be relevant to understand synaptic toxic effects of proteins with abnormal polyQ repeats.

Granes per a l' arqueologia [Ressenya de l'article de Buxó i Capdevila, Ramón. Metodología y técnicas para la recuperación de restos vegetales (en especial referéncia a semillas y frutos) en yacimientos arqueológicos. Cahier Noir, núm. 5, 63 p. Girona, 1990]

Ressenya de l'article de Ramón Buxó i Capdevila,'Metodología y técnicas para la recuperación de restos vegetales (en especial referéncia a semillas y frutos) en yacimientos arqueológicos', publicat al número 5 de 'Cahier Noir' l'any 1991. Es reflexiona sobre les disciplines auxiliars de l' Arqueologia

Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus

BACKGROUND. Several lines of evidence suggest that chemokines and cytokines play an important role in the inflammatory development and progression of systemic lupus erythematosus. The aim of this study was to evaluate the relevance of functional genetic variations of RANTES, IL-8, IL-1alpha, and MCP-1 for systemic lupus erythematosus. METHODS. The study was conducted on 500 SLE patients and 481 ethnically matched healthy controls. Genotyping of polymorphisms in the RANTES, IL-8, IL-1alpha, and MCP-1 genes were performed using a real-time polymerase chain reaction (PCR) system with pre-developed TaqMan allelic discrimination assay. RESULTS. No significant differences between SLE patients and healthy controls were observed when comparing genotype, allele or haplotype frequencies of the RANTES, IL-8, IL-1alpha, and MCP-1 polymorphisms. In addition, no evidence for association with clinical sub-features of SLE was found. CONCLUSION. These results suggest that the tested functional variation of RANTES, IL-8, IL-1alpha, and MCP-1 genes do not confer a relevant role in the susceptibility or severity of SLE in the Spanish population.

Hipertrofia benigna de próstata : cáncer de próstata : proceso asistencial integrado. 3ª ed

Publicado en la página web de la Consejería de Salud y Bienestar Social: www.juntadeandalucia.es/salud (Consejería de Salud y Bienestar Social / Profesionales / Nuestro Compromiso por la Calidad / Procesos Asistenciales Integrados)

Acute oxygen sensing in heme oxygenase-2 null mice.

Hemeoxygenase-2 (HO-2) is an antioxidant enzyme that can modulate recombinant maxi-K(+) channels and has been proposed to be the acute O(2) sensor in the carotid body (CB). We have tested the physiological contribution of this enzyme to O(2) sensing using HO-2 null mice. HO-2 deficiency leads to a CB phenotype characterized by organ growth and alteration in the expression of stress-dependent genes, including the maxi-K(+) channel alpha-subunit. However, sensitivity to hypoxia of CB is remarkably similar in HO-2 null animals and their control littermates. Moreover, the response to hypoxia in mouse and rat CB cells was maintained after blockade of maxi-K(+) channels with iberiotoxin. Hypoxia responsiveness of the adrenal medulla (AM) (another acutely responding O(2)-sensitive organ) was also unaltered by HO-2 deficiency. Our data suggest that redox disregulation resulting from HO-2 deficiency affects maxi-K(+) channel gene expression but it does not alter the intrinsic O(2) sensitivity of CB or AM cells. Therefore, HO-2 is not a universally used acute O(2) sensor.

N-3 fatty acids, cancer and cachexia: a systematic review of the literature.

Use of n-3 fatty acids (FA) has been reported to be beneficial for cancer patients. We performed a systematic review of the literature in order to issue recommendations on the clinical use of n-3 FA in the cancer setting. A systematic search was performed in MEDLINE, EMBASE, Cochrane and Healthstar databases. We selected clinical trials or prospective observational studies including patients with cancer and life expectancy >2 months, in which enteral supplements with n-3 FA were administered. Parameters evaluated individually were clinical (nutritional status, tolerance, survival and hospital stays), biochemical (inflammatory mediators), and functional (functional status, appetite and quality of life (QoL)). Seventeen studies met the inclusion criteria; eight were of high quality. The panel of experts established the following evidence: (1) oral supplements with n-3 FA benefit patients with advanced cancer and weight loss, and are indicated in tumours of the upper digestive tract and pancreas; (2) the advantages observed were: increased weight and appetite, improved QoL, and reduced post-surgical morbidity; (3) there is no defined pattern for combining different n-3 FA, and it is recommended to administer > 1.5 g/day; and (4) better tolerance is obtained administering low-fat formulas for a period of at least 8 weeks. All the evidences were grade B but for 'length of treatment' and 'advantage of survival' it was grade C. Our findings suggest that administration of n-3 FA (EPA and DHA) in doses of at least 1.5 g/day for a prolonged period of time to patients with advanced cancer is associated with an improvement in clinical, biological and QoL parameters.

Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans.

Immune-mediated nephritis contributes to disease in systemic lupus erythematosus, Goodpasture syndrome (caused by antibodies specific for glomerular basement membrane [anti-GBM antibodies]), and spontaneous lupus nephritis. Inbred mouse strains differ in susceptibility to anti-GBM antibody-induced and spontaneous lupus nephritis. This study sought to clarify the genetic and molecular factors that maybe responsible for enhanced immune-mediated renal disease in these models. When the kidneys of 3 mouse strains sensitive to anti-GBM antibody-induced nephritis were compared with those of 2 control strains using microarray analysis, one-fifth of the underexpressed genes belonged to the kallikrein gene family,which encodes serine esterases. Mouse strains that upregulated renal and urinary kallikreins exhibited less evidence of disease. Antagonizing the kallikrein pathway augmented disease, while agonists dampened the severity of anti-GBM antibody-induced nephritis. In addition, nephritis-sensitive mouse strains had kallikrein haplotypes that were distinct from those of control strains, including several regulatory polymorphisms,some of which were associated with functional consequences. Indeed, increased susceptibility to anti-GBM antibody-induced nephritis and spontaneous lupus nephritis was achieved by breeding mice with a genetic interval harboring the kallikrein genes onto a disease-resistant background. Finally, both human SLE and spontaneous lupus nephritis were found to be associated with kallikrein genes, particularly KLK1 and the KLK3 promoter, when DNA SNPs from independent cohorts of SLE patients and controls were compared. Collectively, these studies suggest that kallikreins are protective disease-associated genes in anti-GBM antibody-induced nephritis and lupus.

Clinical audit of COPD patients requiring hospital admissions in Spain: AUDIPOC study.

BACKGROUNDS AUDIPOC is a nationwide clinical audit that describes the characteristics, interventions and outcomes of patients admitted to Spanish hospitals because of an exacerbation of chronic obstructive pulmonary disease (ECOPD), assessing the compliance of these parameters with current international guidelines. The present study describes hospital resources, hospital factors related to case recruitment variability, patients' characteristics, and adherence to guidelines. METHODOLOGY/PRINCIPAL FINDINGS An organisational database was completed by all participant hospitals recording resources and organisation. Over an 8-week period 11,564 consecutive ECOPD admissions to 129 Spanish hospitals covering 70% of the Spanish population were prospectively identified. At hospital discharge, 5,178 patients (45% of eligible) were finally included, and thus constituted the audited population. Audited patients were reassessed 90 days after admission for survival and readmission rates. A wide variability was observed in relation to most variables, hospital adherence to guidelines, and readmissions and death. Median inpatient mortality was 5% (across-hospital range 0-35%). Among discharged patients, 37% required readmission (0-62%) and 6.5% died (0-35%). The overall mortality rate was 11.6% (0-50%). Hospital size and complexity and aspects related to hospital COPD awareness were significantly associated with case recruitment. Clinical management most often complied with diagnosis and treatment recommendations but rarely (<50%) addressed guidance on healthy life-styles. CONCLUSIONS/SIGNIFICANCE The AUDIPOC study highlights the large across-hospital variability in resources and organization of hospitals, patient characteristics, process of care, and outcomes. The study also identifies resources and organizational characteristics associated with the admission of COPD cases, as well as aspects of daily clinical care amenable to improvement.