Perspectivas hermenêuticas de Isaías 45,1-7: Uma análise do título messiânico atribuído a Ciro.

O livro do profeta Dêutero-Isaías aborda que Javé vem consolar seu povo exilado na Babilônia. O rei estrangeiro Ciro, no texto de Is 45,1-7 é intitulado de Messias de Javé. Portanto, esta pesquisa tem como objetivo refletir sobre o título messiânico atribuído ao rei Ciro, no contexto do exílio babilônico. Para isto, analiso algumas contribuições de diversos autores e autoras da área bíblica, explorando a diversidade de pesquisas sobre este tema. Há muitas interpretações sobre o significado do título messiânico atribuído ao rei Ciro, entre elas, há quem define Ciro como o Messias de Javé, ou seja, Ciro como libertador dos exilados e não como o substituto da esperança messiânica em um Messias proveniente da casa de Davi. Neste trabalho, discuto ainda a esperança messiânica, manifesta no período exílico e pós-exílico, destacando a fé que as comunidades messiânicas exerciam nestes períodos. Enfim, analiso o messianismo das comunidades pós-macabaicas e neo-testamentárias na tentativa de descobrir se Ciro era uma figura messiânica, nestes períodos.

NÃO TEMAS! GRITEI POR TEU NOME: Estudo da concepção materna de Javé em Dêutero- Isaías a partir da análise exegética de Is 43,1-7

O presente estudo exegético tem por objetivo demonstrar a face materna de Javé revelada nos textos de Dêutero-Isaías, tendo como fonte principal o oráculo de salvação de Is 43,1-7. Para tal, partimos da análise do contexto literário, histórico e religioso de Dêutero-Isaías, paraentão fazer a análise exegética do texto proposto, através da qual enfocaremos, dentre os diversos conteúdos, a característica materna apresentada na perícope. Compreendendo que um texto surge dentro de um ambiente social, evidenciaremos, com base nos escritos de Dêutero-Isaías, a comunidade exilada à qual se dirigem profetas e profetisas. Por fim, combinando os atributos maternos das deusas Asherah e Ishtar com a incipiente concepção materna de Javé apresentado por Oséias, propomos a face materna de Deus com base nos textos dêuteroisaiânicos, em especial, Is 43,1-7.

N-terminal His7-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity

Glucagon-like peptide-1(7-36)amide (GLP-1) possesses several unique and beneficial effects for the potential treatment of type 2 diabetes. However, the rapid inactivation of GLP-1 by dipeptidyl peptidase IV (DPP IV) results in a short half-life in vivo (less than 2 min) hindering therapeutic development. In the present study, a novel His7-modified analogue of GLP-1, N-pyroglutamyl-GLP-1 as well as N-acetyl-GLP-1 were synthesised and tested for DPP IV stability and biological activity. Incubation of GLP-1 with either DPP IV or human plasma resulted in rapid degradation of native GLP-1 to GLP-1(9-36)amide, while N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 were completely resistant to degradation. N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 bound to the GLP-1 receptor but had reduced affinities (IC50 values 32.9 and 6.7 nM, respectively) compared with native GLP-1 (IC50-37 nM). Similarly, both analogues stimulated cAMP production with EC50 values of 16.3 and 27 nM respectively compared with GLP-1 (EC50 4.7 nM). However, N-acetyl-GLP-1 and N-pyroglutamyl-GLP-1 exhibited potent insulinotropic activity in vitro at 5.6 mM glucose (P< 0.05 to P< 0.001) similar to native GLP-1. Both analogues (25 nM/kg body weight) lowered plasma glucose and increased plasma insulin levels when administered in conjunction with glucose (18 nM/kg body weight) to adult obese diabetic (ob/ob) mice. N-pyroglutamyl-GLP-1 was substantially better at lowering plasma glucose compared with the native peptide, while N-acetyl-GLP-1 was significantly more potent at stimulating insulin secretion. These studies indicate that N-terminal modification of GLP-1 results in DPP IV-resistant and biologically potent forms of GLP-1. The particularly powerful antihyperglycaemic action of N-pyroglutamyl-GLP-1 shows potential for the treatment of type 2 diabetes. © 2004 Society for Endocrinology.

Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39)

The incretin hormone glucagon-like peptide-1(7-36)amide (GLP-1) has been deemed of considerable importance in the regulation of blood glucose. Its effects, mediated through the regulation of insulin, glucagon, and somatostatin, are glucose-dependent and contribute to the tight control of glucose levels. Much enthusiasm has been assigned to a possible role of GLP-1 in the treatment of type 2 diabetes. GLIP-l's action unfortunately is limited through enzymatic inactivation caused by dipeptidylpeptidase IV (DPP IV). It is now well established that modifying GLP-1 at the N-terminal amino acids, His7 and Ala8, can greatly improve resistance to this enzyme. Little research has assessed what effect Glu9-substitution has on GLP-1 activity and its degradation by DPP IV. Here, we report that the replacement of Glu9 of GLP-1 with Lys dramatically increased resistance to DPP IV. This analogue (Lys9)GLP-1, exhibited a preserved GLP-1 receptor affinity, but the usual stimulatory effects of GLP-1 were completely eliminated, a trait duplicated by the other established GLP-1-antagonists, exendin (9-39) and GLP-1 (9-36)amide. We investigated the in vivo antagonistic actions of (Lys9)GLP-1 in comparison with GLP-1(9-36)amide and exendin (9-39) and revealed that this novel analogue may serve as a functional antagonist of the GLP-1 receptor.

Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo

Although the incretin hormone glucagon-like peptide-1 (GLP-1) is a potent stimulator of insulin release, its rapid degradation in vivo by the enzyme dipeptidyl peptidase IV (DPP IV) greatly limits its potential for treatment of type 2 diabetes. Here, we report two novel Ala8-substituted analogues of GLP-1, (Abu8)GLP-1 and (Val8)GLP-1 which were completely resistant to inactivation by DPP IV or human plasma. (Abu8)GLP-1 and (Val8)GLP-1 exhibited moderate affinities (IC50: 4.76 and 81.1 nM, respectively) for the human GLP-1 receptor compared with native GLP-1 (IC50: 0.37 nM). (Abu8)GLP-1 and (Val8)GLP-1 dose-dependently stimulated cAMP in insulin-secreting BRIN BD11 cells with reduced potency compared with native GLP-1 (1.5- and 3.5-fold, respectively). Consistent with other mechanisms of action, the analogues showed similar, or in the case of (Val8)GLP-1 slightly impaired insulin releasing activity in BRIN BD11 cells. Using adult obese (ob/ob) mice, (Abu8 )GLP-1 had similar glucose-lowering potency to native GLP-1 whereas the action of (Val8)GLP-1 was enhanced by 37%. The in vivo insulin-releasing activities were similar. These data indicate that substitution of Ala8 in GLP-1 with Abu or Val confers resistance to DPP IV inactivation and that (Val8)GLP-1 is a particularly potent N-terminally modified GLP-1 analogue of possible use in type 2 diabetes.

Generation of 1.7-μJ pulses at 1.55μm by a self-modelocked all-fiber laser with a kilometers-long linear-ring cavity

We report on the record-high pulse energy of nearly 1.7 μJ obtained directly from a self-mode-locked all-fiber erbium laser with a linear-ring cavity owing its extreme elongation up to several kilometers. Specially selected telecommunication fibers, providing large normal net cavity dispersion in the vicinity of 1.55 μm, have been used for this purpose. Along with compensation for polarization instability in the longer linear arm of the cavity, such approach has ensured stable wavebreaking- free mode-locked lasing with an ultra-low pulse repetition rate of 35.1 kHz. © 2010 by Astro Ltd.

Mapping of the Eltanin impact area in the South-East Pacific

Two Polarstern expeditions were conducted in 1995 (ANT-XII/4) and 2001 (ANT-XVIII/5a) to the Bellingshausen Sea and Amundsen Sea and the suspected Eltanin meteorite impact in the SE-Pacific. A survey of the sediment distribution and its acoustic structure along the cruise track was performed. The seafloor topography was sampled using the multibeam sonar system Hydrosweep DS2 which operates on a frequency of 15.5 kHz. The resulting AWI Bathymetric Chart of the Eltanin Meteorite Impact Area is based on a Digital Terrain Model of this area. The mapping was performed using ArcGIS. The Eltanin impact area which covers the 4.100 m high Freden Seamount is visualized by one overview sheet of the scale 1:200,000 and four 1:100,000 subsheets.

Interactions between Late Quaternary volcanic and sedimentary processes in the Naples Bay, Southern Tyrrhenian sea

The interactions between Late Quaternary volcanic and sedimentary processes in the Naples Bay, Southern Tyrrhenian sea, are here discussed through the results of the marine geological survey at the scale 1:25.000. The example of the geological map n. 465 “Isola di Procida”, herein presented, has put in evidence the stratigraphy of marine Quaternary deposits and related volcanic seismic units. The volcanic deposits cropping out in the Procida island have been explained as the result of eruptions of local eruptive centres. The geological survey carried out onshore indicates the occurrence of several pyroclastic units linked to the eruptive activity of the Ischian and Phlegrean volcanic complexes, interstratified with the products erupted by local volcanic centres. The occurrence in the pyroclastic sequences of Ischia and Procida islands of several marker horizons and their stratigraphic correlations have allowed to reconstruct the volcanological evolution of the two islands and the interactions with sedimentary processes at the scale of the whole Tyrrhenian margin. Four geological maps at the scale 1:25.000 covering the whole Naples Bay have been reconstructed based on the interpretation of marine geological and geophysical data. The stratigraphic relationships between the seismic units and the eruptive deposits have testified the activity of several monogenetic volcanic centers, whose products are interstratified with marine and continental deposits of the Late Quaternary depositional sequence.

Appalachian Trail /

"March 1981."

State of Connecticut.

Scale 1:125,000: 1 in. equals approx. 2 miles.