Gedenkschrift : uitgegeven ter gelegenheid van het 300-jarig bestaan der onderwijsinrichtingen Talmud Tora en Ets Hai͏̈m bij de Port. Israe͏̈l. Gemeente te Amsterdam : 5376 - 5676

M. C. Paraira en J. S. da Silva Rosa

Assessment of the role of LASER-Doppler in the treatment of port-wine stains in infants

BACKGROUND Port-wine stains (PWS) are malformations of capillaries in 0.3% of newborn children. The treatment of choice is by pulsed dye LASER (PDL), and requires several sessions. The efficacy of this treatment is at present evaluated on the basis of clinical inspection and of digital photographs taken throughout the treatment. LASER-Doppler imaging (LDI) is a noninvasive method of imaging the perfusion of the tissues by the microcirculatory system (capillaries). The aim of this paper is to demonstrate that LDI allows a quantitative, numerical evaluation of the efficacy of the PDL treatment of PWS. METHOD The PDL sessions were organized according to the usual scheme, every other month, from September 1, 2012, to September 30, 2013. LDI imaging was performed at the start and at the conclusion of the PDL treatment, and simultaneously on healthy skin in order to obtain reference values. The results evidenced by LDI were analyzed according to the "Wilcoxon signed-rank" test before and after each session, and in the intervals between the three PDL treatment sessions. RESULTS Our prospective study is based on 20 new children. On average, the vascularization of the PWS was reduced by 56% after three laser sessions. Compared with healthy skin, initial vascularization of PWS was 62% higher than that of healthy skin at the start of treatment, and 6% higher after three sessions. During the 2 months between two sessions, vascularization of the capillary network increased by 27%. CONCLUSION This study shows that LDI can demonstrate and measure the efficacy of PDL treatment of PWS in children. The figures obtained when measuring the results by LDI corroborate the clinical assessments and may allow us to refine, and perhaps even modify, our present use of PDL and thus improve the efficacy of the treatment.

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 305 - Mitteilung an den Professor Hugo von Meltzl über seinen Umzug von Port-au-Prince nach Berlin

u.a.: Pensionierung; Verhandlung mit dem Stuttgarter Verlag W. Spemann wegen der geplanten Veröffentlichung zu Baron Münchhausen; Absatz des bei Brockhaus erschienenen Publikation des Schopenhauer-Nachlasses; Eduard Grisebach; W. Spemann;

Ms. lat. qu. 15 - De technica microcosmi historia T. II, Tr. 1, Sect. 2, Port. 1-7

Vorbesitzer: Johann Maximilian Zum Jungen

Geschichte von Port-Royal : der Kampf des reformirten und des jesuitischen Katholicismus unter Louis XIII und XIV

Hermann Reuchlin