An extract from the will of Samuel Emlen, of Burlington, N.J., who died 12th month 29th, 1837, creating a trust for the benefit of persons of Indian and African descent.

Interleaved.

Our navy; extract from the Lucky Bag on the reorganization of the navy.

Signed: - Harry Bluff [pseud]

The female pilgrim, or, The travels of Hephzibah : under the similtude of a dream, in which is given an historical account of the Pilgrim's extract ...

Attributed to John Mitchell in Mansell 388:25.

Extract of the review of Lord Byron's Hours of idleness, from Edinburgh review, no. XXII., which occasioned "English bards and Scotch reviewers".

Mode of access: Internet.

Defence of Lieut. Col. Gardner Burbank : before the general court-martial, whereof Maj. Gen. Nathaniel Goodwin was president, held at Hathaway's Hall, in Worcester, on the 8th September, 1818, against charges preferred against him, by Col. Prentice Cushing and others : to which is prefixed an extract from the records of said court, containing all the evidence adduced upon his trials.

Mode of access: Internet.

Explanation of the views of the Society for Employing the Poor : with the constitution and by-laws; and an extract from the report of the managers, for the first three months, and a list of subscribers' names.

Shoemaker

An extract from the Report of the directors of Massachusetts State Prison, made to his excellency the governor and the honourable council. October 18, 1827. : Reviewing certain parts of the Second annual report of the Prison Discipline Society.

Mode of access: Internet.

Descendants of Jaquelin Ambler : with letters from his daughter, Mrs. Col. Ed. Carrington, and extract from his funeral sermon delivered by Rev. John Buchanan /

Mode of access: Internet.

Pabst Malt extract" giant bottle in window of Palmer's Pharmacy, 46 S. State St., Ann Arbor c. 1896-9

Glass negative is overexposed. hs13234: actual unchanged scan, hs13234alt: increased contrast in Photoshop to allow for image to be clearer

An historical account of Cumner; with some particulars of the traditions respecting the death of the Countess of Leicester; also an extract from Ashmole's Antiquities of Berkshire, relative to that transaction and illustrative of the romance of Kenilworth. To which is added an appendix, containing the original ballad of Cumner Hall, and other interesting matter.

Mode of access: Internet.

Report of the committee on the Wills Legacy; with an extract from the will of the late James Wills and the ordinances for the management of the Wills hospital.

Report addressed: To the Select and Common Councils of Philadelphia. - p. 3.

Leukocyte subset responses during exercise under heat stress with carbohydrate or water intake

Purpose: This study investigated leukocyte subset responses to moderate-intensity exercise under heat stress, with water (W) or carbohydrate (CHO) drink ingestion. Methods: In repeated trials, 13 soldiers consumed either a W or CHO drink during 3 h of walking at 4.4 km center dot h(-1) with a 5% gradient (15 min rest per hour) under heat stress (35 C and 55% relative humidity). The soldiers wore combat uniforms and carried water bottles and dummy rifles and ammunition, altogether weighing about 11.5 +/- 1.0 kg. Results: Plasma glucose concentration was significantly higher with CHO than W ingestion during exercise (p < 0.01). There were no significant differences between W and CHO conditions in exercise performance, plasma cortisol concentration, heart rate, or core temperature. CHO ingestion significantly moderated the increases in leukocyte (83% in W, 28% in CHO; p < 0.001), monocyte (60% in W, 34% in CHO; p < 0.05), and granulocyte counts (120% in W, 30% in CHO; p < 0.001), but not in lymphocyte count (41% in W, 25% in CHO). Conclusions: The increases in leukocyte and subset counts during moderate-intensity exercise under heat stress may be comparable to those observed during intense exercise in cool conditions. The response of immune cell counts is blunted by CHO intake during moderate-intensity exercise in the heat, and may not occur through the cortisol pathway.

Investigation of oxidative stress defenses of Neisseria gonorrhoeae by using a human polymorphonuclear leukocyte survival assay

Neisseria gonorrhoeae has well-characterized oxidative stress defense systems that protect against oxidative killing in in vitro assays. In contrast, mutant strains of N. gonorrhoeae lacking oxidative stress defenses are identical to the wild type when tested in an ex vivo survival assay using human polymorphonuclear leukocytes.

Generation and maturation of dendritic cells for clinical application under serum-free conditions

Monocyte-derived dendritic cells (MoDCs) in clinical use for cancer immunotherapy are ideally generated in serum-free medium (SFM) with inclusion of a suitable maturation factor toward the end of the incubation period. Three good manfacturing practice (GMP) grade SFMs (AIM-V, X-VIVO 15, and X-VIVO 20) were compared with RPMI-1640, supplemented with 10% fetal bovine serum or 10% human serum. DCs generated for 7 days in SFM were less mature and secreted less interleukin (IL) 12p70 and IL-10 than DCs generated in 10% serum. DC yield was comparable in SFMs, and a greater proportion of cells was viable after maturation. Toll-like receptor (TLR) ligands were compared for their ability to induce cytokine secretion under serum-free conditions in the presence of interferon (IFN) gamma. With the exception of Poly I:C, TLR ligands stimulated high levels of IL-10 secretion. High levels of IL-12p70 were induced by two TLR4-mediated stimuli, lipopolysaccharide and Ribomunyl, a clinical-grade bacterial extract. When T-cell responses were compared in allogeneic mixed leukocyte reaction, DCs stimulated with Ribomunyl induced higher levels of IFN gamma than DCs stimulated with the cytokine cocktail: tumor necrosis factor-alpha, IL-1 beta, IL-6, and prostaglandin E-2. In the presence of IL-10 neutralizing antibodies, DC IL-12p70 production and T-cell IFN gamma were increased in vitro. Similarly, DCs stimulated with Ribomunyl, IFN gamma, and anti-IL-10 induced high levels of tetanus toxoid-specific T-cell proliferation and IFN gamma secretion. Thus, MoDCs generated ill SFM efficiently stimulate T-cell IFN gamma production after maturation in the presence of a clinical-grade TLR4 agonist and IL-10 neutralization.