Social Democracy, Globalization and Governance: Why is there no European Left Program in the EU? CES Germany & Europe Working Papers, No. 00.6, April 2000

This paper addresses globalization and governance in the EU by attempting to generate some plausible hypotheses that might explain the policy choices of the 12 out of 15 European democratic left governments. With all of the discussion in recent years of a democratic deficit, and then need to maintain a "social Europe," why have these governments not produced more explicit left-wing policies? It suggests three possible hypotheses to account for this apparently mysterious outcome. Hypothesis #1: They want to but they can't. Hypothesis #2: They don't want to because they aren't really left anymore. Hypothesis #3: They could, but they all are suffering from a fundamental failure of imagination. The paper explores each of these hypotheses in two ways. First it examines the initial years of the Schröder government in Germany apparently, pursuing each of these three hypotheses and different times during this period. Then it looks more systematically and comparatively and each of the three hypotheses by including analysis both of Germany and several other EU member states. The larger goal of this work is to provoke discussion and research on what role left political movements can actually play. Is it even reasonable to expect such a group of nation states to develop innovative forms of cross-national governance? Or are new and/or revised forms of representation and governance beyond traditional nation-state models.

Zalpha-domains: At the intersection between RNA editing and innate immunity

The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections. However, in only a few cases an antiviral role was ever demonstrated and surprisingly, it turns out that ADARs - the RNA editing enzymes - may have a prominent pro-viral role through the modulation/down-regulation of the interferon response. A key role in this regulatory function of RNA editing is played by ADAR1, an interferon inducible RNA editing enzyme. A distinguishing feature of ADAR1, when compared with other ADARs, is the presence of a Z-DNA binding domain, Zalpha. Since the initial discovery of the specific and high affinity binding of Zalpha to CpG repeats in a left-handed helical conformation, other proteins, all related to the interferon response pathway, were shown to have similar domains throughout the vertebrate lineage. What is the biological function of this domain family remains unclear but a significant body of work provides pieces of a puzzle that points to an important role of Zalpha domains in the recognition of foreign nucleic acids in the cytoplasm by the innate immune system. Here we will provide an overview of our knowledge on ADAR1 function in interferon response with emphasis on Zalpha domains.

Surgical cryoablation for ventricular tachyarrhythmia arising from the left ventricular outflow tract region.

BACKGROUND Ventricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) region can be inaccessible for ablation because of epicardial fat or overlying coronary arteries. OBJECTIVE We describe surgical cryoablation of this type of VA. METHODS From March 2009 to 2014, 190 consecutive patients with VAs originating from the LVOT underwent ablation at our institution. Four patients (2%) underwent surgical cryoablation for highly symptomatic VAs after failing catheter ablation. RESULTS In all patients, endocardial or percutaneous epicardial mapping was consistent with origin in the LVOT. In 2 patients, the points of earliest activation during VAs were marked with a bipolar pacing lead in the overlying cardiac vein for guidance during surgery. Surgical cryoablation was successful in 3 of the 4 patients. The fourth patient subsequently had successful endocardial catheter ablation. During a mean follow-up of 22 ± 16 months (range 4-42 months), all patients showed abolition of or marked reduction in symptomatic VA. However, 1 patient subsequently required percutaneous intervention to the left anterior descending coronary artery; another developed progressive left ventricular systolic dysfunction caused by nonischemic cardiomyopathy; and a third patient underwent permanent pacemaker implantation because of complete atrioventricular block after concomitant aortic valve replacement. CONCLUSION Surgical cryoablation is an option for highly symptomatic drug-resistant VAs emanating from the LVOT region. Despite extensive preoperative mapping, the procedure is not effective for all patients, and coronary injury is a risk.

Top left: Res. of Horace N. Johnson, Sec. 29, Dexter Tp. Mich. Top right: Res. of John Costell, Dexter, Mich. Bottom: St. Joseph's Catholic Church, Dexter, Michigan

Dexter, Mich. residences and church. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Top left: F. Sorg, house sign and ornamental painter, dealer in oils, varnishes, glass, 26 & 28 East Washington St., Ann Arbor, Mich. Left: Res. of Mrs. Chas. Behr, Ann Arbor, Mich.; Botttom: Res. of Andrew Ten Brook, Ann Arbor, Mich. (na11,064)

Ann Arbor, Mich. residences and business. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Left: Livery & Sale Stables, J.A. Polhemus & Son, Proprs., Ann Arbor, Mich. Left: Buchoz's Block, Ann Arbor, Mich. Bottom: Orchestrian Hall, Fred Rettich, Proprietor, Ann Arbor, Mich.

Ann Arbor, Mich. businesses. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Left: Res. of John Starkweather, Sec. 5, Ypsilanti Tp. Mich. Right: Res. of Edwin Crane, Sec. 25, Pittsfield Tp. Mich. Bottom: Res. of A. Worden, Congress St. Ypsilanti, Michigan

Ypsilanti, Pittsfield Township (Mich.) residences. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Left: Union School, Ypsilanti, Mich. Right: Res. of J.C. Gillett, Sec.6, Ypsilanti Tp. Mich. Bottom: Res. of J.S. Worden, Congress St., Ypsilanti, Mich.

Ypsilanti, Mich. school and residences. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Left: Res. of J.S. Henderson, Sec. 5, Pittsfield Tp. Mich. Right: Res. of Randall Ross, Sec. 24, Pittsfield Tp. Mich. Bottom: Res. of Allen N. Crittenden, Sec. 35, Pittsfield Tp. Mich.

Pittsfield Township (Mich.) residences. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Top Left: Mr. O.C. Sweetland. Top Right: Mrs. O.C. Sweetland. Bottom: Res. of O.C. Sweetland, Sec. 9, Lodi Tp. Michigan

Lodi Township (Mich.) residence. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Top left: Paint Creek Cheese Factory, H.W. Smith, proprietor, Sec. 3, Augusta Tp. Mich. Top right: Res. of Hiram P. Thompson, Sec. 19, Augusta Tp. Mich.; Res. of Webster Childs, Sec. 15, Augusta Tp. Mich.

Augusta Township (Mich.) residences and businesses. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Top left: Res. of Aaron Childs, Sec. 4, Augusta Tp., Mich. Top right: Res. of G. Muir, Sec. 9, Augusta Tp. Mich. Bottom: Res. of Robert Campbell, Sec. 4, Augusta Tp. Mich.

Augusta Township (Mich.) residences. Inset: Sheep barn & young orchard of Robt Campbell. Publication information: Chicago, Ill. : Everts & Stewart, 1874.

Boulder with plaque beside elm tree planted by the class of 1869. In front of Angell Hall to the left of the steps. Gift of the Class of 1869.

On verso: M-10