1000 resultados para Jarry, Alfred (1873-1907)


Relevância:

20.00% 20.00%

Publicador:

Resumo:

von Lorenz Curtius

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Raphael Strauß

Relevância:

20.00% 20.00%

Publicador:

Resumo:

Boberach: Die Forderung des Wiener Sicherheitsausschusses, Windischgrätz abzusetzen, wird zurückgewiesen, die Verurteilung von Prager Aufständischen durch die Provisorische Untersuchungskommission gerechtfertigt. Den Ultraradikalen in Wien wird vorgeworfen, daß sie nicht merken, als Mittel zum Zweck mißbraucht zu werden, damit das Deutschtum im Slawentum aufgehen kann, [sowie] Polen, Tschechen und Italiener die Monarchie ruinieren können. Wer eine deutsche Flotte will, darf von Österreich nicht verlangen, Venedig und Italien aufzugeben

Relevância:

20.00% 20.00%

Publicador:

Resumo:

BACKGROUND Nicotine addiction is a major public health problem and is associated with primary glutamatergic dysfunction. We recently showed marked global reductions in metabotropic glutamate receptor type 5 (mGluR5) binding in smokers and recent ex-smokers (average abstinence duration of 25 weeks). The goal of this study was to examine the role of mGluR5 downregulation in nicotine addiction by investigating a group of long-term ex-smokers (abstinence >1.5 years), and to explore associations between mGluR5 binding and relapse in recent ex-smokers. METHODS Images of mGluR5 receptor binding were acquired in 14 long-term ex-smokers, using positron emission tomography with radiolabeled [11C]ABP688, which binds to an allosteric site with high specificity. RESULTS Long-term ex-smokers and individuals who had never smoked showed no differences in mGluR5 binding in any of the brain regions examined. Long-term ex-smokers showed significantly higher mGluR5 binding than recent ex-smokers, most prominently in the frontal cortex (42%) and thalamus (57%). CONCLUSIONS Our findings suggest that downregulation of mGluR5 is a pathogenetic mechanism underlying nicotine dependence and the high relapse rate in individuals previously exposed to nicotine. Therefore, mGluR5 receptor binding appears to be an effective biomarker in smoking and a promising target for the discovery of novel medication for nicotine dependence and other substance-related disorders.