A case-control study of tea/coffee consumption and lung cancer risk

Background. Despite the increasing attention to the effects of dietary factors on lung cancer risk, epidemiological research on the role of black/green tea and coffee intake and lung cancer risk is scarce. The purpose of this study was to explore the following three hypotheses: (1) the preventive (protective) effect from lung cancer is higher in green tea than in black tea and coffee consumption. (2) brewed tea (either black or green) daily drinkers have lower odds of lung cancer than non-drinkers of brewed tea (3) regular black and green tea have more preventive effect against lung cancer than decaffeinated teas due to the synergistic effect of caffeine and other tea components. ^ Methods. Data on 1,088 lung cancer cases and 1,127 controls from an ongoing epidemiological study of lung cancer by the Department of Epidemiology of the University of Texas M.D. Anderson Cancer were analyzed. Multiple logistic regressions were performed for testing associations between frequency of specific types of tea/coffee consumption and the risk of lung cancer. ^ Results. We observed that more than a cup a week of green tea and decaffeinated black tea were significantly associated with reduced odds of lung cancer by 64% for green tea (adjusted OR = 0.44; 95% CI = 0.31–0.64), 36% for decaffeinated black tea (OR = 0.64; 95% CI = 0.45–0.90), when compared with non-drinkers and those who drank less than a cup a week. On the other hand, increasing intake of regular coffee (more than 3 cups a day) was associated with a 30% higher odds ratio of lung cancer (OR = 1.30; 95% CI = 1.01–1.09). No association was found between regular black tea, decaffeinated coffee consumption and the odds ratio of lung cancer. However, when drinkers of other tea/coffee beverages were excluded from each model in order to explore the independent effect of each type of tea/coffee, green tea and decaffeinated black tea-lung cancer associations remained but no association was observed for drinkers of regular coffee. ^ Conclusion. We report the chemopreventive effects of more than a cup a week of green tea and decaffeinated black tea on lung cancer. ^

Financial performance drivers and strategic control: The case of cancer treatment centers

Strategic control is defined as the use of qualitative and quantitative tools for the evaluation of strategic organizational performance. Most research in strategic planning has focused on strategy formulation and implementation, but little work has been done on strategic performance evaluation particularly in the area of cancer research. The objective of this study was to identify strategic control approaches and financial performance metrics used by major cancer centers in the country as an initial step in expanding the theory and practice behind strategic organizational performance. Focusing on hospitals which share similar mandate and resource constraints was expected to improve measurement precision. The results indicate that most cancer centers use a wide selection of evaluation tools, but sophisticated analytical approaches were less common. In addition, there was evidence that high-performing centers tend to invest a larger degree of resources in the area of strategic performance analysis than centers showing lower financial results. The conclusions point to the need for incorporating higher degree of analytical power in order to improve the tracking of strategic performance. This study is one of the first to concentrate in the area of strategic control.^

Genetic variability and the hypothalamic control of energy balance

Background. Obesity is a major health problem throughout the industrialized world. Despite numerous attempts to curtail the rapid growth of obesity, its incidence continues to rise. Therefore, it is crucial to better understand the etiology of obesity beyond the concept of energy balance.^ Aims. The first aim of this study was to first investigate the relationship between eating behaviors and body size. The second goal was to identify genetic variation associated with eating behaviors. Thirdly, this study aimed to examine the joint relationships between eating behavior, body size and genetic variation.^ Methods. This study utilized baseline data ascertained in young adults from the Training Interventions and Genetics of Exercise (TIGER) Study. Variables assessed included eating behavior (Emotional Eating Scale, Eating Attitudes Test-26, and the Block98 Food Frequency Questionnaire), body size (body mass index, waist and hip circumference, waist/hip ratio, and percent body fat), genetic variation in genes implicated related to the hypothalamic control of energy balance, and appropriate covariates (age, gender, race/ethnicity, smoking status, and physical activity. For the genetic association analyses, genotypes were collapsed by minor allele frequency, and haplotypes were estimated for each gene. Additionally, Bayesian networks were constructed in order to determine the relationships between genetic variation, eating behavior and body size.^ Results. We report that the EAT-26 score, Caloric intake, percent fat, fiber intake, HEAT index, and daily servings of vegetables, meats, grains, and fats were significantly associated with at least one body size measure. Multiple SNPs in 17 genes and haplotypes from 12 genes were tested for their association with body size. Variation within both DRD4 and HTR2A was found to be associated with EAT-26 score. In addition, variation in the ghrelin gene (GHRL) was significantly associated with daily Caloric intake. A significant interaction between daily servings of grains and the HEAT index and variation within the leptin receptor gene (LEPR) was shown to influence body size.^ Conclusion. This study has shown that there is a substantial genetic component to eating behavior and that genetic variation interacts with eating behavior to influence body size.^

Dietary patterns and risk of pancreatic cancer in a hospital-based case-control study

Background. It is important to understand the association between diet and risk of pancreatic cancer in order to better understand the etiology of pancreatic cancer.^ Objectives. Describe the dietary patterns of cases of adenocarcinoma of the pancreas and non-cancer controls and evaluate the odds of having a healthy eating pattern among cases and non-cancer controls.^ Design and Methods. An ongoing hospital-based case-control study was conducted in Houston, Texas from 2000-2008 with 678 pancreatic adenocarcinoma cases and 724 controls. Participants completed a food frequency questionnaire and a risk factor questionnaire. Dietary patterns were derived by principal component analysis and associations between dietary patterns and pancreatic cancer risk were assessed using unconditional logistic regression.^ Results. Two dietary patterns were derived: fruit-vegetable and high fat-meat. There were no statistically significant associations between the fruit-vegetable pattern and pancreatic cancer. An inverse association was seen between the high fat-meat pattern and pancreatic cancer risk when comparing those in the upper intake quintile to those scoring in the lowest quintile after adjusting for demographic and risk factor variables (OR=0.67, p=0.03). In sex-stratified analysis adjusted for demographic and risk factor variables, females scoring in the upper intake quintile of the fruit-vegetable pattern had a 49% lower risk of pancreatic cancer compared to females scoring in the lowest quintile (OR=0.51, p=0.03). An inverse relationship was also seen for the high fat-meat pattern when comparing females in the upper intake quintile to females in the lowest quintile (OR=0.50, p=0.03). In males, neither dietary pattern was significantly associated with pancreatic cancer.^ Conclusions. The current findings for the fruit-vegetable pattern are similar to those of previous studies and support the hypothesis that there is an inverse association between a “healthy” diet (comprised of fruits, vegetables, and whole grains) and risk of having pancreatic cancer (in females only). However, the inverse relationship with the high fat-meat pattern and risk of pancreatic cancer is contrary to other results. Further research on dietary patters and pancreatic cancer risk may lead to better understanding of the etiologic cause of pancreatic cancer.^

Leukemia and occupational exposure to electromagnetic fields: An incident case-control study

The existence of an association between leukemia and electromagnetic fields (EMF) is still controversial. The results of epidemiologic studies of leukemia in occupational groups with exposure to EMF are inconsistent. Weak associations have been seen in a few studies. EMF assessment is lacking in precision. Reported dose-response relationships have been based on qualitative levels of exposure to EMF without regard to duration of employment or EMF intensity on the jobs. Furthermore, potential confounding factors in the associations were not often well controlled. The current study is an analysis of the data collected from an incident case-control study. The primary objective was to test the hypothesis that occupational exposure to EMF is associated with leukemia, including total leukemia (TL), myelogenous leukemia (MYELOG) and acute non-lymphoid leukemia (ANLL). Potential confounding factors: occupational exposure to benzene, age, smoking, alcohol consumption, and previous medical radiation exposures were controlled in multivariate logistic regression models. Dose-response relationships were estimated by cumulative occupational exposure to EMF, taking into account duration of employment and EMF intensity on the jobs. In order to overcome weaknesses of most previous studies, special efforts were made to improve the precision of EMF assessment. Two definitions of EMF were used and result discrepancies using the two definitions were observed. These difference raised a question as to whether the workers at jobs with low EMF exposure should be considered as non-exposed in future studies. In addition, the current study suggested use of lifetime cumulative EMF exposure estimates to determine dose-response relationship. The analyses of the current study suggest an association between ANLL and employment at selected jobs with high EMF exposure. The existence of an association between three types of leukemia and broader categories of occupational EMF exposure, is still undetermined. If an association does exist between occupational EMF exposure and leukemia, the results of the current study suggest that EMF might only be a potential factor in the promotion of leukemia, but not its initiation. ^

SOCIO-ENVIRONMENTAL FACTORS ASSOCIATED WITH THE DISTRIBUTION OF DRACUNCULUS MEDINENSIS (GUINEA WORM DISEASE) AND SUGGESTED METHODS FOR CONTROL, IBARAPA, NIGERIA, 1982 (AFRICA)

A population-based cross-sectional survey of socio-environmental factors associated with the prevalence of Dracunculus medinensis (guinea worm disease) was conducted in Idere, a rural agricultural community in Ibarapa, Oyo state, Nigeria, during 1982.^ The epidemiologic data were collected by household interview of all 501 households. The environmental data were collected by analysis of water samples collected from all domestic water sources and rainfall records.^ The specific objectives of this research were to: (a) Describe the prevalence of guinea worm disease in Idere during 1982 by age, sex, area of residence, drinking water source, religion and weekly amount of money spent by the household to collect potable drinking water. (b) Compare the characteristics of cases with non-cases of guinea worm in order to identify factors associated with high risk of infection. (c) Investigate domestic water sources for the distribution of Cyclops. (d) Determine the extent of potable water shortage with a view to identifying factors responsible for such shortage in the community. (e) Describe the effects of guinea worm on school attendance during 1980/1982 school years by class and location of school from piped water supply.^ The findings of this research indicate that during 1982, 31.8 percent of Idere's 6,527 residents experienced guinea worm infection, with higher prevalence of infection recorded in males in their most productive years and females in their teenage years. The role of sex and age to risk of higher infection rate was explained in the context of water related exposure and water intake due to dehydration from physical occupational actitives of subgroups.^ Potable water available to residents was considerably below the minimum recommended by WHO for tropical climates, with sixty-eight percent of water needs of the residents coming from unprotected surface water which harbour Cyclops, the obligatory intermediate host of Dracunculus medinensis. An association was found between periods of relative high density of Cyclops in domestic water and rainfall.^ Impact of guinea worm infection on educational activities was considerable and its implications were discussed, including the implications of the research findings in relation to control of guinea worm disease in Ibarapa. ^

Diagramas de flujo para el diseño de un sistema de control de calidad : proceso de elaboración de vino blanco

Para la implementación de un sistema de control de calidad es necesario tener una clara visión de los procesos involucrados, las responsabilidades, organización, registros de la calidad, acciones preventivas y correctivas. En la actualidad se exige un enfoque integrador, donde se estructuran actividades y recursos físicos. Es por ello que los diagramas de flujo tienen una importancia fundamental en las decisiones de dirección. Entre los distintos diagramas de flujo posibles, en este trabajo se propone utilizar los de procesos que permiten ordenar secuencialmente una serie de actividades y recursos físicos. Se presenta un diagrama de flujo en la elaboración de vino blanco en una bodega experimental. A través de él se puede conocer la lógica del proceso de elaboración, realizar un diagnóstico del proceso, detectar los puntos críticos de control que puedan provocar deterioro en la calidad del producto o del ambiente. También es un punto de partida para armar y poner en funcionamiento un plan de inspección y ensayos, para la documentación necesaria en las auditorías y una técnica para detectar puntos de contaminación ambiental.

Las leyes sobre vagancia : Control policial y práctica judicial en el ocaso de la frontera (Tandil 1872-1881)

A fines de la década de 1870, el gobierno provincial, con el objeto de lograr mayor control social sobre la población rural, implementó una reestructuración policial en la campaña bonaerense. La misma tenía por objetivo afianzar la propiedad privada y contribuir al mercado de trabajo, asimismo perseguía un fuerte interés en satisfacer la necesidad del estado de hombres en plena etapa de expansión de la frontera. La presión reclutadora del estado se reflejará en un aumento de detenidos por vagancia, dado que las leyes de represión de la vagancia del Código Rural permitían su penalización al servicio de las armas. El Código Rural sancionado en 1865 estipulaba dos normas procesales a cumplir en los acusados: formación de un sumario y constitución de un jury para su juzgamiento. Disposiciones que raramente se pusieron en práctica por los jueces de paz desde que esta legislación entró en vigencia. Será a fines de la década de 1870 cuando el gobierno exigirá más firmemente no solo la persecución de la vagancia sino también la aplicación de estas normas procesales en los acusados. Aún así, el análisis de la práctica judicial revelará que continuará existiendo una constante manipulación normativa sobre la base de dos valores que se intentaban afianzar, el trabajo y la propiedad. En los perjudiciales que atentaran contra estos dos valores, será en quienes se manipulará la normativa sancionada y se canalizará la presión reclutadora.

Las leyes sobre vagancia : Control policial y práctica judicial en el ocaso de la frontera (Tandil 1872-1881)

A fines de la década de 1870, el gobierno provincial, con el objeto de lograr mayor control social sobre la población rural, implementó una reestructuración policial en la campaña bonaerense. La misma tenía por objetivo afianzar la propiedad privada y contribuir al mercado de trabajo, asimismo perseguía un fuerte interés en satisfacer la necesidad del estado de hombres en plena etapa de expansión de la frontera. La presión reclutadora del estado se reflejará en un aumento de detenidos por vagancia, dado que las leyes de represión de la vagancia del Código Rural permitían su penalización al servicio de las armas. El Código Rural sancionado en 1865 estipulaba dos normas procesales a cumplir en los acusados: formación de un sumario y constitución de un jury para su juzgamiento. Disposiciones que raramente se pusieron en práctica por los jueces de paz desde que esta legislación entró en vigencia. Será a fines de la década de 1870 cuando el gobierno exigirá más firmemente no solo la persecución de la vagancia sino también la aplicación de estas normas procesales en los acusados. Aún así, el análisis de la práctica judicial revelará que continuará existiendo una constante manipulación normativa sobre la base de dos valores que se intentaban afianzar, el trabajo y la propiedad. En los perjudiciales que atentaran contra estos dos valores, será en quienes se manipulará la normativa sancionada y se canalizará la presión reclutadora.

Las leyes sobre vagancia : Control policial y práctica judicial en el ocaso de la frontera (Tandil 1872-1881)

A fines de la década de 1870, el gobierno provincial, con el objeto de lograr mayor control social sobre la población rural, implementó una reestructuración policial en la campaña bonaerense. La misma tenía por objetivo afianzar la propiedad privada y contribuir al mercado de trabajo, asimismo perseguía un fuerte interés en satisfacer la necesidad del estado de hombres en plena etapa de expansión de la frontera. La presión reclutadora del estado se reflejará en un aumento de detenidos por vagancia, dado que las leyes de represión de la vagancia del Código Rural permitían su penalización al servicio de las armas. El Código Rural sancionado en 1865 estipulaba dos normas procesales a cumplir en los acusados: formación de un sumario y constitución de un jury para su juzgamiento. Disposiciones que raramente se pusieron en práctica por los jueces de paz desde que esta legislación entró en vigencia. Será a fines de la década de 1870 cuando el gobierno exigirá más firmemente no solo la persecución de la vagancia sino también la aplicación de estas normas procesales en los acusados. Aún así, el análisis de la práctica judicial revelará que continuará existiendo una constante manipulación normativa sobre la base de dos valores que se intentaban afianzar, el trabajo y la propiedad. En los perjudiciales que atentaran contra estos dos valores, será en quienes se manipulará la normativa sancionada y se canalizará la presión reclutadora.

GPS raw data (control points and ground control points) from the Liguria Region, Borghetto Santo Spirito, Italy

Monitoring the impact of sea storms on coastal areas is fundamental to study beach evolution and the vulnerability of low-lying coasts to erosion and flooding. Modelling wave runup on a beach is possible, but it requires accurate topographic data and model tuning, that can be done comparing observed and modeled runup. In this study we collected aerial photos using an Unmanned Aerial Vehicle after two different swells on the same study area. We merged the point cloud obtained with photogrammetry with multibeam data, in order to obtain a complete beach topography. Then, on each set of rectified and georeferenced UAV orthophotos, we identified the maximum wave runup for both events recognizing the wet area left by the waves. We then used our topography and numerical models to simulate the wave runup and compare the model results to observed values during the two events. Our results highlight the potential of the methodology presented, which integrates UAV platforms, photogrammetry and Geographic Information Systems to provide faster and cheaper information on beach topography and geomorphology compared with traditional techniques without losing in accuracy. We use the results obtained from this technique as a topographic base for a model that calculates runup for the two swells. The observed and modeled runups are consistent, and open new directions for future research.

Soporte de redes activas para un servicio integrado de multipunto fiable con control de congestión

Las limitaciones de las tecnologías de red actuales, identificadas en la Agencia de Proyectos de Investigación Avanzados para la Defensa (DARPA) durante 1995, han originado recientemente una propuesta de modelo de red denominado Redes Activas. En este modelo, los nodos proporcionan un entorno de ejecución sobre el que se ejecuta el código asociado a cada paquete. El objetivo es disponer de una tecnología de red que permita que nuevos servicios de red sean desarrollados e instalados rápidamente sin modificar los nodos de la red. Un servicio de red que se puede beneficiar de esta tecnología es la transmisión de datos en multipunto con diferentes grados fiabilidad. Las propuestas actuales de servicios de multipunto fiable proporcionan una solución específica para cada clase de aplicaciones, y los protocolos existentes extremo a extremo sufren de limitaciones técnicas relacionadas con una fiabilidad limitada, y con la ausencia de mecanismos de control de congestión efectivos. Esta tesis realiza propuestas originales conducentes a solucionar parte de las limitaciones actuales en el ámbito de Redes Activas y multipunto fiable con control de congestión. En primer lugar, se especificará un servicio genérico de multipunto fiable que, basándose en los requisitos de una serie de aplicaciones consideradas relevantes, proporcione diferentes clases de sesiones y grados de fiabilidad. Partiendo de la definición del servicio genérico especificado, se diseñará un protocolo de comunicaciones sobre la tecnología de Redes Activas que proporcione dicho servicio. El protocolo diseñado estará dotado de un mecanismo de control de congestión para que la fuente ajuste dinámicamente el tráfico inyectado a las condiciones de carga de la red. En esta tesis se pretende también profundizar en el estudio y análisis de la tecnología de Redes Activas, experimentando con dicha tecnología para proporcionar una realimentación a sus diseñadores. Dicha experimentación se realizará en tres ámbitos: el de los servicios y protocolos que puede soportar, el del modelo y arquitectura de las Redes Activas y el de las plataformas de ejecución disponibles. Como aportación adicional de este trabajo, se validarán los objetivos anteriores mediante una implementación piloto de las entidades de protocolo y de su interfaz de servicio sobre uno de los entornos de ejecución disponibles. Abstract The limitations of current networking technologies identified in the Defense Advance Research Projects Agency (DARPA) along 1995 have led to a recent proposal of a new network model called Active Networks. In this model, the nodes provide an execution environment over which the code used to process each packet is executed. The objective is a network technology that allows the fast design and deployment of new network services without requiring the modification of the network nodes. One network service that could benefit from this technology is the transmission of multicast data with different types of loss tolerance. The current proposals for reliable multicast services provide specific solutions for each application class, and existing end-to-end protocols suffer from technical drawbacks related to limited reliability and lack of an effective congestion control mechanism. This thesis contains original proposals that aim to solve part of the current drawbacks in the scope of Active Networks and reliable multicast with congestion control. Firstly, a generic reliable multicast network service will be specified. This service will be designed from the requirements of a relevant set of applications, and will provide different session classes and different types of reliability. Then, a network protocol based on Active Network technology will be designed such that it provides the specified network service. This protocol will incorporate a congestion control mechanism capable of performing an automatic adjustment of the traffic injected by the source to the available network capacity. This thesis will also contribute to a deeper study and analysis of Active Network technology, by experimenting with the technology in order to provide feedback to its designers. This experimentation will be done attending to three different scopes: support of Active Network for services and protocols, Active Network model and architecture, and currently available Active Network execution environments. As an additional contribution of this work, the previous objectives will be validated through a prototype implementation of the protocol entities and the service interface based on one of the current execution environments.

Rotation-Induced Breakdown of Torsional Quantum Control

Control of the torsional angles of nonrigid molecules is key for the development of emerging areas like molecular electronics and nanotechnology. Based on a rigorous calculation of the rotation-torsion-Stark energy levels of nonrigid biphenyl-like molecules, we show that, unlike previously believed, instantaneous rotation-torsion-Stark eigenstates of such molecules, interacting with a strong laser field, present a large degree of delocalization in the torsional coordinate even for the lowest energy states. This is due to a strong coupling between overall rotation and torsion leading to a breakdown of the torsional alignment. Thus, adiabatic control of changes on the planarity of this kind of molecule is essentially impossible unless the temperature is on the order of a few Kelvin.

New methods for the estimation of Takagi-Sugeno model based extended Kalman filter and its applications to optimal control for nonlinear systems

This paper describes new approaches to improve the local and global approximation (matching) and modeling capability of Takagi–Sugeno (T-S) fuzzy model. The main aim is obtaining high function approximation accuracy and fast convergence. The main problem encountered is that T-S identification method cannot be applied when the membership functions are overlapped by pairs. This restricts the application of the T-S method because this type of membership function has been widely used during the last 2 decades in the stability, controller design of fuzzy systems and is popular in industrial control applications. The approach developed here can be considered as a generalized version of T-S identification method with optimized performance in approximating nonlinear functions. We propose a noniterative method through weighting of parameters approach and an iterative algorithm by applying the extended Kalman filter, based on the same idea of parameters’ weighting. We show that the Kalman filter is an effective tool in the identification of T-S fuzzy model. A fuzzy controller based linear quadratic regulator is proposed in order to show the effectiveness of the estimation method developed here in control applications. An illustrative example of an inverted pendulum is chosen to evaluate the robustness and remarkable performance of the proposed method locally and globally in comparison with the original T-S model. Simulation results indicate the potential, simplicity, and generality of the algorithm. An illustrative example is chosen to evaluate the robustness. In this paper, we prove that these algorithms converge very fast, thereby making them very practical to use.

Estrategias para el control microclimático del espacio entre edificaciones en clima cálido – húmedo

La presente investigación parte del problema en las zonas de clima cálido - húmedo en las cuales se producen impactos asociados a la incomodidad térmica producto de la intensa radiación solar, altas temperaturas y elevada humedad. Estos factores reducen la calidad de los espacios abiertos y desarrollan en la población una actitud de rechazo hacia el uso del microespacio urbano entre edificaciones en los desarrollos urbanos - conjuntos urbanos - , los mismos frecuentemente admiten soluciones que al parecer no contribuyen a la realización de las actividades comunes de esparcimiento de la población residente. Por lo tanto, el objetivo de la investigación es profundizar en la temática urbano - ambiental - social y el diseño urbano vinculada a la particularidad morfológica local, las condiciones microclimáticas, el uso del microespacio y los requerimientos de los usuarios. La finalidad de desarrollar estrategias de control microclimático del microespacio entre edificios en clima cálido - húmedo en búsqueda de soluciones óptimas que satisfagan las necesidades de los usuarios de los espacios exteriores en estas áreas residenciales. La investigación se centra en el estudio de las particularidades contextuales relacionadas con el microclima y las características urbanas - morfotipológicas, básicamente los factores microclimáticos (soleamiento y ventilación), los morfológicos y edificatorios y las características de las superficies (pavimentos). En coherencia con el objetivo propuesto el trabajo se desarrolla en cuatro fases: la primera aborda la revisión documental, literatura relevante e investigaciones relativas a la calidad ambiental, medio social, medio físico, el microespacio urbano, control y diseño sostenible, modelización proyectual y estrategias sostenibles; la segunda fase se refiere al marco contextual, características urbanas, datos climáticos locales, planes y procesos urbanos, tipologías y conformación urbana. En esta fase se describe el proceso de selección, análisis y evaluación urbano - ambiental de los casos de estudio (conjuntos residenciales). En la tercera fase se aborda el marco evaluativo y estudio de casos, consideraciones físicas, climáticas y valoración térmico - ambiental de los conjuntos residenciales seleccionados. En esta fase se aplican Técnicas Estadísticas y de Simulación Computacional y se analizan los resultados obtenidos. Finalmente, la cuarta fase propositiva incluye el establecimiento de Estrategias, Principios y Lineamientos de optimación térmica y se exponen las Conclusiones parciales de la tesis, alcances y perspectivas futuras. Finalmente, los resultados obtenidos en la investigación demuestran que el análisis en las experiencias de la realidad permiten comprobar que las situaciones y alteraciones ambientales sustanciales, los niveles de afectación térmica y las condiciones de confortabilidad e impacto derivan de las características urbanas, los componentes del microespacio y de las condiciones climáticas las cuales afectan el desarrollo de las actividades y el uso efectivo del microespacio entre edificios. El análisis de los factores morfo - climáticos incidentes y el estudio de los efectos de interacción contribuyen al establecimiento de Principios y Lineamientos para la evaluación y diseño sostenible del microespacio entre edificios y el uso correcto de los elementos del clima en estas áreas urbanas destinadas a la actividad social y al esparcimiento de la población residente. ABSTRACT This research starts from the problem of hot - humid climate zones where impacts related to thermal discomfort are produced as a result from the intense solar radiation and high temperatures and humidity. These factors reduce the quality of open spaces and people develop an attitude of rejection towards the use of urban microspace among buildings within urban developments - urban complexes - . Usually, these complexes admit solutions that apparently do not contribute to the achievement of common leisure activities in the resident dwellers. Therefore, the main purpose of this research is to deepen in the urban - environmental - social issue and urban design linked to the local morphological particularity, microclimate conditions, use of microspace and users’ requirements. In order to develop microclimate control strategies of microspace among buildings in hot - humid climate to look for optimal solutions that satisfy users’ needs of outdoors spaces in these residential areas. The research focuses in the study of contextual particularities related to microclimate and urban - morphotypological characteristics. Basically, microclimate (sunlight and ventilation), morphological and building factors as well as road surface characteristics. According to the proposed objective, this research is developed in four phases: the first one considers documentary review, relevant literature and researches related to environmental quality, social environment, physical environment, urban microspace, control and sustainable design, project modelling and sustainable strategies; while the second phase refers to contextual framework, urban characteristics, local climate data, plans and urban processes, typologies and urban structure. In this phase, the process of selection, analysis and urban - environmental evaluation of case studies (residential complexes) is described. The third phase approaches the assessment framework and case studies, physical and climate considerations as well as environmental - thermal evaluation of selected residential complexes. In this phase, statistical techniques and computational simulations are applied. Likewise, results obtained are analysed. Similarly, fourth and proposing phase includes the establishment of strategies, principles and guidelines of thermal optimization and partial conclusions of the thesis, scopes and future perspectives are exposed. Finally, from the results obtained, it is demonstrated that the analysis on reality experiences allow proving that situations and substantial environmental changes, levels of thermal affectations, comfort conditions and impact derive from urban characteristics, microspace components and from climate conditions which affect the development of activities and the effective use of microspace among buildings. The analysis of incidental morpho - climate factors and the study of interaction effects contribute to the establishment of principles and guidelines for the assessment and sustainable design of microspace among buildings as well as the correct use of climate elements in these urban areas oriented to social and leisure activities of resident population.