Iowa Individual Income Tax School District Report, Tax Year 2001

Iowa School District Surtax Report 2001

Iowa Individual Income Tax School District Report, Tax Year 2002

Iowa School District Surtax Report 2002

Iowa Individual Income Tax School District Report, Tax Year 2003

Iowa School District Surtax Report 2003

Iowa Individual Income Tax School District Report, Tax Year 2004

Iowa School District Surtax Report 2004

Iowa Individual Income Tax School District Report, Tax Year 2005

Iowa School District Surtax Report 2005

Iowa Individual Income Annual Tax Statistical Report 1997

Iowa Individual Income Tax Statistical Report 1997

Iowa Individual Income Tax Annual Statistical Report 1998

Iowa Individual Income Tax Statistical Report 1998

Iowa Individual Income Tax Annual Statistical Report 1999

Iowa Individual Income Tax Statistical Report 1999

Iowa Individual Income Tax Annual Statistical Report 2000

Iowa Individual Income Tax Statistical Report 2000

Iowa Individual Income Tax Annual Statistical Report 2001

Iowa Individual Income Tax Statistical Report 2001

Iowa Individual Income Tax Annual Statistical Report 2002

Iowa Individual Income Tax Statistical Report 2002

Iowa Individual Income Tax Annual Statistical Report 2003

Iowa Individual Income Tax Statistical Report 2003

Iowa Individual Income Tax Annual Statistical Report 2004

Iowa Individual Income Tax Statistical Report 2004

Iowa Individual Income Tax Annual Statistical Report 2005

Iowa Individual Income Tax Statistical Report 2005

Increased mobility of major histocompatibility complex I-peptide complexes decreases the sensitivity of antigen recognition.

CD8(+) cytotoxic T lymphocytes (CTL) can recognize and kill target cells expressing only a few cognate major histocompatibility complex (MHC) I-peptide complexes. This high sensitivity requires efficient scanning of a vast number of highly diverse MHC I-peptide complexes by the T cell receptor in the contact site of transient conjugates formed mainly by nonspecific interactions of ICAM-1 and LFA-1. Tracking of single H-2K(d) molecules loaded with fluorescent peptides on target cells and nascent conjugates with CTL showed dynamic transitions between states of free diffusion and immobility. The immobilizations were explained by association of MHC I-peptide complexes with ICAM-1 and strongly increased their local concentration in cell adhesion sites and hence their scanning by T cell receptor. In nascent immunological synapses cognate complexes became immobile, whereas noncognate ones diffused out again. Interfering with this mobility modulation-based concentration and sorting of MHC I-peptide complexes strongly impaired the sensitivity of antigen recognition by CTL, demonstrating that it constitutes a new basic aspect of antigen presentation by MHC I molecules.