Bologna, la citta dei flussi: Riqualificare e connettere tra architettura e movimento

La città di Bologna, la storia, i flussi e le connessioni. Questo progetto di gruppo nasce dalla necessità di ripensare il ruolo dell’infrastruttura nella contemporaneità e nell’atteggiamento che l’architettura può assumere di fronte alle rinnovate priorità delle città italiane che, tra espansione demografica, monumenti e centri storici da preservare, nuove reti di comunicazione e scambio delle informazioni, necessitano sempre più di una pianificazione che prenda in analisi il passato, interpreti il presente e si ponga l’obiettivo primario di dialogare con il futuro. Il capoluogo Emiliano è collocato in una posizione strategica per le comunicazioni d i trasporti, tenendo uniti gli estremi dello stivale e svolgendo un ruolo di snodo a cui oggi la penisola Italiana non può in alcun modo rinunciare. Ogni giorno una quantità spropositata di pendolari e viaggiatori è indotta nella città concentrandosi in un primo momento nell’area della stazione ferroviaria e dei piazzali antistanti, per poi distribuirsi all’interno del tessuto urbano, chi utilizzando il sistema di rete tramviaria, chi a piedi o in bicicletta. L’intento principale del masterplan proposto è quindi valutare un range di informazioni supplementari ai tradizionali studi urbani. Si è notato come le aree più degradate della città (spesso limitrofe ad infrastrutture consegnate al comune senza valutarne l’integrazione e l’impatto urbano e ambientale) manchino di una circolazione costante e di attività. Si è identificato nelle migliaia di soggetti che ogni giorno giungono a Bologna usufruendo dei servizi delle Ferrovie dello Stato la linfa vitale di un’importante parte della città. Poiché progettare per un futuro prossimo è pensare a un presente in grado di accettare i propri limiti e assimilare le aberrazioni del passato, rifacendosi ad un immaginario che non può che sconfinare i paradigmi prefissati che hanno portato ad uno status irrisolto ma non irrisolvibile.

Assimilation of data from conventional and non conventional networks through a LETKF scheme in the COSMO model

The present work studies a km-scale data assimilation scheme based on a LETKF developed for the COSMO model. The aim is to evaluate the impact of the assimilation of two different types of data: temperature, humidity, pressure and wind data from conventional networks (SYNOP, TEMP, AIREP reports) and 3d reflectivity from radar volume. A 3-hourly continuous assimilation cycle has been implemented over an Italian domain, based on a 20 member ensemble, with boundary conditions provided from ECMWF ENS. Three different experiments have been run for evaluating the performance of the assimilation on one week in October 2014 during which Genova flood and Parma flood took place: a control run of the data assimilation cycle with assimilation of data from conventional networks only, a second run in which the SPPT scheme is activated into the COSMO model, a third run in which also reflectivity volumes from meteorological radar are assimilated. Objective evaluation of the experiments has been carried out both on case studies and on the entire week: check of the analysis increments, computing the Desroziers statistics for SYNOP, TEMP, AIREP and RADAR, over the Italian domain, verification of the analyses against data not assimilated (temperature at the lowest model level objectively verified against SYNOP data), and objective verification of the deterministic forecasts initialised with the KENDA analyses for each of the three experiments.

Using Smalltalk as a Reflective Executable Meta-Language

Object-oriented meta-languages such as MOF or EMOF are often used to specify domain specific languages. However, these meta-languages lack the ability to describe behavior or operational semantics. Several approaches used a subset of Java mixed with OCL as executable meta-languages. In this paper, we report our experience of using Smalltalk as an executable and integrated meta-language. We validated this approach in incrementally building over the last decade, Moose, a meta-described reengineering environment. The reflective capabilities of Smalltalk support a uniform way of letting the base developer focus on his tasks while at the same time allowing him to meta-describe his domain model. The advantage of our this approach is that the developer uses the same tools and environment

Expression and hypoxic regulation of the endothelin system in endocrine cells of human and rat pancreatic islets

CONTEXT: The success of pancreatic islet transplantation depends largely on the capacity of the islet graft to survive the initial phase immediately after transplantation until revascularization is completed. Endothelin-1 (ET-1) is a strong vasoconstrictor which has been involved in solid organ graft failure but is also known to be a potent mitogenic/anti-apoptotic factor which could also potentially enhance the survival of the transplanted islets. OBJECTIVE: Characterization of the endothelin system with regard to a potential endothelin agonist/antagonist treatment. DESIGN: Regulated expression of the endothelin system in human and rat pancreatic islets and beta-cell lines was assessed by means of immunohistochemistry, competition binding studies, western blot, RT-PCR, real-time PCR and transplant studies. RESULTS: ET-1, ETA- and ETB-receptor immunoreactivity was identified in the endocrine cells of human and rat pancreatic islets. The corresponding mRNA was detectable in rat beta-cell lines and isolated rat and human pancreatic islets. Competition binding studies on rat islets revealed binding sites for both receptor types. ET-1 stimulated the phosphorylation of mitogen-activated protein kinase, which was prevented by ETA- and ETB-receptor antagonists. After exposure to hypoxia equal to post-transplant environment oxygen tension, mRNA levels of ET-1 and ETB-receptor of human islets were robustly induced whereas ETA-receptor mRNA did not show significant changes. Immunostaining signals for ET-1 and ETA-receptor of transplanted rat islets were markedly decreased when compared to native pancreatic sections. CONCLUSIONS: In pancreatic islets, ET-1 and its receptors are differentially expressed by hypoxia and after transplantation. Our results provide the biological basis for the study of the potential use of endothelin agonists/antagonists to improve islet transplantation outcome.

Dendrogeomorphology in badlands: Methods, case studies and prospects

Soil and vegetation are interacting factors controlling erosion. Soil degradation processes may affect the normal tree and shrub development and inversely, vegetation can modulate the velocity and intensity of soil development or denudation. A dendrogeomorphological approach can be used to study these interactions, allowing to obtain a date and estimate mean or specific erosion rates. This is especially useful in an unrecorded badlands and gullied environments, where the scarce vegetation may be the only proxy available to quantify the different geomorphic processes which have occurred. This paper provides a fundamental review of the dendrogeomorphological methodology applied to erosion measurement in badlands. Focusing on the response of the vegetation to the geomorphic processes, this paper: (a) describes the methodology developed to estimate erosion rates with exposed roots; (b) shows new advances through case studies; and finally, (c) discusses future lines of research to reduce methodological uncertainties and for making dendrogeomorphology more widely applicable.

Prospects for measuring the gravitational free-fall of antihydrogen with emulsion detectors

The main goal of the AEgIS experiment at CERN is to test the weak equivalence principle for antimatter. AEgIS will measure the free-fall of an antihydrogen beam traversing a moir'e deflectometer. The goal is to determine the gravitational acceleration with an initial relative accuracy of 1% by using an emulsion detector combined with a silicon μ-strip detector to measure the time of flight. Nuclear emulsions can measure the annihilation vertex of antihydrogen atoms with a precision of ~ 1–2 μm r.m.s. We present here results for emulsion detectors operated in vacuum using low energy antiprotons from the CERN antiproton decelerator. We compare with Monte Carlo simulations, and discuss the impact on the AEgIS project.

Development of nuclear emulsions with 1 μm spatial resolution for the AEgIS experiment

The main goal of the AEgIS experiment at CERN is to test the weak equivalence principle for antimatter. We will measure the Earth ' s gravitational acceleration g with antihydrogen atoms being launched in a horizontal vacuum tube and traversing a moiré de fl ectometer. We intend to use a position sensitive device made of nuclear emulsions (combined with a time-of- fl ight detector such as silicon μ strips) to measure precisely their annihilation points at the end of the tube. The goal is to determine g with a 1% relative accuracy. In 2012 we tested emulsion fi lms in vacuum and at room temperature with low energy antiprotons from the CERN antiproton decelerator. First results on the expected performance for AEgIS are presented

Mesenchymal stem cells and collagen patches for anterior cruciate ligament repair

AIM: To investigate collagen patches seeded with mesenchymal stem cells (MSCs) and/or tenocytes (TCs) with regards to their suitability for anterior cruciate ligament (ACL) repair. METHODS: Dynamic Intraligamentary Stabilization (DIS) utilizes a dynamic screw system to keep ACL remnants in place and promote biological healing, supplemented by collagen patches. How these scaffolds interact with cells and what type of benefit they provide has not yet been investigated in detail. Primary ACL-derived TCs and human bone marrow derived MSCs were seeded onto two different types of 3D collagen scaffolds, Chondro-Gide® (CG) and Novocart® (NC). Cells were seeded onto the scaffolds and cultured for 7 days either as a pure populations or as “premix” containing a 1 : 1 ratio of TCs to MSCs. Additionally, as controls, cells were seeded in monolayers and in co-cultures on both sides of porous high-density membrane inserts (0.4µm). We analyzed the patches by real time polymerase chain reaction (RT-PCR), glycosaminoglycan (GAG), DNA and hydroxy-proline (HYP) content, was determined. To determine cell spreading and adherence in the scaffolds microscopic imaging techniques, i.e. confocal laser scanning microscopy (cLSM) and scanning electron microscopy (SEM), were applied. RESULTS: CLSM and SEM imaging analysis confirmed cell adherence onto scaffolds. The metabolic cell activity revealed that patches promote adherence and proliferation of cells. The most dramatic increase in absolute metabolic cell activity was measured for CG samples seeded with tenocytes or a 1:1 cell premix. Analysis of DNA content and cLSM imaging also indicated MSCs were not proliferating as nicely as tenocytes on CG. The HYP to GAG ratio significantly changed for the premix group, resulting from a slightly lower GAG content, demonstrating that the cells are modifying the underlying matrix. Real-time quantitative polymerase chain reaction data indicated that MSCs showed a trend of differentiation towards a more tenogenic-like phenotype after 7 days. CONCLUSION: CG and NC are both cyto-compatible with primary MSCs and TCs; TCs seemed to perform better on these collagen patches than MSCs.

The Aristarchus Proyect on line (www.aristarchus.it) : Electronic Tools for Classical Philology

El artículo está destinado a subrayar el proyecto ARISTARCUS, un conjunto de herramientas de trabajo para la investigación y la enseñanza en temas del área de mundo antiguo Griego y Latino y está disponible en el sitio web www.aristarchus.unige.it. Ha sido llevado a cabo por el grupo de investigación del Dipartimento di Archeologia e Filologia Classica (DARFICLET) de la Universidad de Génova, dirigido por el Profesor Franco Montanari. El sitio web incluye cinco ítems: 1) LGGA - Léxico de los Gramáticos Griegos Antiguos; 2) PAWAG - Palabras escasamente atestadas en Griego Antiguo; 3) CPhCl - Catalogus Philologorum Classicorum; 4) CIAPh - Centro Italiano de l'Année Philologique; 5) Mediaclassica, un conjunto de herramientas para la enseñanza de Griego y Latín.