Synaptic vesicle endocytosis mediates the entry of tetanus neurotoxin into hippocampal neurons

Tetanus neurotoxin causes the spastic paralysis of tetanus by blocking neurotransmitter release at inhibitory synapses of the spinal cord. This is due to the penetration of the toxin inside the neuronal cytosol where it cleaves specifically VAMP/synaptobrevin, an essential component of the neuroexocytosis apparatus. Here we show that tetanus neurotoxin is internalized inside the lumen of small synaptic vesicles following the process of vesicle reuptake. Vesicle acidification is essential for the toxin translocation in the cytosol, which results in the proteolytic cleavage of VAMP/synaptobrevin and block of exocytosis.

A long day's journey into light : school desegregation in Prince George's County.

Includes bibliographical references.

Investigation into more complete use of structural materials through a study of the stress-temperature-time conditions of a re-entry vehicle

Mode of access: Internet.

Control of foot-and-mouth disease. Report of special subcommittee to the Committee on Appropriations, United States Senate, on study of pernicious effect of foot-and-mouth disease as it exists in Mexico and elsewhere, progress of program to prevent entry of the disease into the United States, the most effective methods of combating and controlling the disease and the proper location for the authorized research facilities.

Kenneth S. Wherry, chairman of subcommittee.

Outlines of a plan for the establishment of an agricultural model school in the province of Munster : as recommended by the Irish Relief Committee in London of 1822, who appropriated three thousand pounds of their remaning funds, to aid in carrying this object into effect.

Includes "Appendix. Report of the Committee of the N.W. Society concerning an agricultural seminary" and "Extracts from Travels in Switzerland by S. Simond, respecting Mr. Fellenberg's establishment at Hofwyl."

Shorter German reader for beginners in school or college : with notes, vocabulary, and paraphrases for translation into German /

Mode of access: Internet.

Sexual knowledge, in plain and simple language; sexology or knowledge of self and sex for both male and female: especially for the instruction of youths and maidens, young wives and young husbands, all fathers and all mothers, school-teachers and nurses, and all others who feel a need of proper and reliable information on sex hygiene, sex problems, and the best way and the best time to impart sexual knowledge to boys and girls about to enter into manhood and womanhood,

At head of title: Sexual education for sex problems: sex hygiene by highest authority.

Teaching College Writing in a High School Setting: The Impact of Concurrent Enrollment on Teacher Learning and Practice

Thesis (Ph.D.)--University of Washington, 2016-06

Tympanometric findings in children at school entry: A normative study

This study presents tympanometric normative data for Australian children at school entry in view of the lack of age-specific population-based data for this group. Participants were 327 children (164 boys, 163 girls) aged between 5 and 6 years, who had no history of middle ear infection, and passed pure-tone screening at 20 dB HL. Normative values for static admittance (SA), ear canal volume (ECV), tympanometric peak pressure, tympanometric width (TW) and tympanometric gradient were established. Based on these normative data, the use of the ASHA (1997) guidelines for medical referral, in which ECV > 1.0 ml in the presence of a flat tympanogram, SA < 0.3 ml, or TW > 200 daPa may not provide the best criteria for Australian children aged between 5 and 6 years. If SA < 0.3 ml were used instead of SA < 0.16 ml, a greater proportion of Australian children would have failed tympanometry, thus increasing the false alarm rate.

Future Engineers Australia Management Project: Turning high school students into engineering entrepreneurs

There has been a strong move towards entrepreneurial education in high schools and at universities over the past few years. This has been echoed by a call from state governments around Australia to promote enterprise thinking and education in high schools. It also parallels the push within engineering to learn across the traditional boundaries , particularly between engineering and business. To meet this call, The Engineering Link Group (TELG) developed the Future Engineers Australia Management Project (FEAMP) in 2003. The project is based around Enterprise Education, and was inspired by the Smallpeice Year 12 Engineering Management course in the UK. The idea was to take high school students in years 11 and 12 and turn them into ‘engineering entrepreneurs’. This paper presents the design, development and evaluation of FEAMP as a five day residential course for year 11 and 12 students who want to learn more about being entrepreneurs and managers. It is a hands-on activity where the students invent, develop and sell an engineering concept to venture capitalists and ultimately to customers at a trade fair. It has been run successfully for two years, going from strength to strength. © 2005, Australasian Association for Engineering Education

Assessing pupil and school performance by non-parametric and parametric techniques

This paper discusses the use of the non-parametric free disposal hull (FDH) and the parametric multi-level model (MLM) as alternative methods for measuring pupil and school attainment where hierarchical structured data are available. Using robust FDH estimates, we show how to decompose the overall inefficiency of a unit (a pupil) into a unit specific and a higher level (a school) component. By a sample of entry and exit attainments of 3017 girls in British ordinary single sex schools, we test the robustness of the non-parametric and parametric estimates. Finally, the paper uses the traditional MLM model in a best practice framework so that pupil and school efficiencies can be computed.