690 resultados para Dr. Juan Rafael Quesada


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Presentado en las II. Jornadas de Lingüística Vasco-Románica / Euskal-Erromantze Linguistika II. Jardunaldietan aurkeztua (Bilbo, 2007)

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Com dedicatória à Camara dos Deputados do Senador Joaquim José Pais da Silva Sarmento, 1900-1902(na página de rosto)

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1 carta (manuscrita) ; 202x145mm.

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Ponencia leída en el Foro de Comunicaciones IkasArt II (BEC Barakaldo, 2010.06.17)

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José Gonçalves Maia - Representante do Estado de Pernambuco na Conferencia de Limites

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Background The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation and progression. Nimotuzumab is a humanized monoclonal antibody that recognizes the EGFR extracellular domain and reaches Central Nervous System tumors, in nonclinical and clinical setting. While it has similar activity when compared to other anti-EGFR antibodies, it does not induce skin toxicity or hypomagnesemia. Methods A randomized, double blind, multicentric clinical trial was conducted in high grade glioma patients (41 anaplastic astrocytoma and 29 glioblastoma multiforme) that received radiotherapy plus nimotuzumab or placebo. Treatment and placebo groups were well-balanced for the most important prognostic variables. Patients received 6 weekly doses of 200 mg nimotuzumab or placebo together with irradiation as induction therapy. Maintenance treatment was given for 1 year with subsequent doses administered every 3 weeks. The objectives of this study were to assess the comparative overall survival, progression free survival, response rate, immunogenicity and safety. Results The median cumulative dose was 3200 mg of nimotuzumab given over a median number of 16 doses. The combination of nimotuzumab and RT was well-tolerated. The most prevalent related adverse reactions included nausea, fever, tremors, anorexia and hepatic test alteration. No anti-idiotypic response was detected, confirming the antibody low immunogenicity. The mean and median survival time for subjects treated with nimotuzumab was 31.06 and 17.76 vs. 21.07 and 12.63 months for the control group. Conclusions In this randomized trial, nimotuzumab showed an excellent safety profile and significant survival benefit in combination with irradiation.

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Louis Cruls nasceu em Diest, Bélgica, em 1848, e morreu em Paris, em 1908. Formado em Engenharia Civil, desenvolveu notáveis trabalhos nos campos da geografia, geologia, meteorologia e astronomia. Em 1874, mudou-se para o Brail, onde participou de diversas expedições cientìficas, especialmente, pela região do Planalto Central. Foi engenheiro da Comissão da Carta-Geral do Império. Em 1876, foi admitido como voluntário no observatório astronomico do Rio de Janeiro, e em 1884 tornou-se diretor ao suceder o frances E. Liais. Planejou e integrou diversas comissões, entre as quais a de exploração do Planalto Central do Brasil, em 1892, cuja finalidade era identificar e escolher o melhor local para a implantação da futura capital do País.

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This series will include all those people who, by means of their contributions, great and small, played a part in the consolidation of ichthyology in Argentina. The general plan of this work consists of individual factsheets containing a list of works by each author, along with reference bibliography and, whenever possible, personal pictures and additional material. The datasheets will be published primarily in chronological order, although this is subject to change by the availability of materials for successive editions. This work represents another approach for the recovery and revalorization of those who set the foundations of Argentine ichthyology while in diverse historical circumstances. I expect this to be the beginning of a major work that achieves the description of such a significant part of the history of natural sciences in Argentina.