Leopold Letter: A Newsletter of the Leopold Center for Sustainable Agriculture, Summer 2014

The Leopold Center was created by the Iowa Legislature as part of the Iowa Groundwater Protection Act of 1987. The Leopold Center believes contribute to a healthy ways of thinking about markets for Iowa farmers, a better understanding of local ecosystems, public policies and economic practices, and partnerships with consumers.

Leopold Letter: A Newsletter of the Leopold Center for Sustainable Agriculture, Fall 2014

The Leopold Center was created by the Iowa Legislature as part of the Iowa Groundwater Protection Act of 1987. The Leopold Center believes contribute to a healthy ways of thinking about markets for Iowa farmers, a better understanding of local ecosystems, public policies and economic practices, and partnerships with consumers.

Leopold Letter: A Newsletter of the Leopold Center for Sustainable Agriculture, Winter 2014

The Leopold Center was created by the Iowa Legislature as part of the Iowa Groundwater Protection Act of 1987. The Leopold Center believes contribute to a healthy ways of thinking about markets for Iowa farmers, a better understanding of local ecosystems, public policies and economic practices, and partnerships with consumers.

The QUASAR reproducibility study, Part II: Results from a multi-center Arterial Spin Labeling test-retest study.

Arterial Spin Labeling (ASL) is a method to measure perfusion using magnetically labeled blood water as an endogenous tracer. Being fully non-invasive, this technique is attractive for longitudinal studies of cerebral blood flow in healthy and diseased individuals, or as a surrogate marker of metabolism. So far, ASL has been restricted mostly to specialist centers due to a generally low SNR of the method and potential issues with user-dependent analysis needed to obtain quantitative measurement of cerebral blood flow (CBF). Here, we evaluated a particular implementation of ASL (called Quantitative STAR labeling of Arterial Regions or QUASAR), a method providing user independent quantification of CBF in a large test-retest study across sites from around the world, dubbed "The QUASAR reproducibility study". Altogether, 28 sites located in Asia, Europe and North America participated and a total of 284 healthy volunteers were scanned. Minimal operator dependence was assured by using an automatic planning tool and its accuracy and potential usefulness in multi-center trials was evaluated as well. Accurate repositioning between sessions was achieved with the automatic planning tool showing mean displacements of 1.87+/-0.95 mm and rotations of 1.56+/-0.66 degrees . Mean gray matter CBF was 47.4+/-7.5 [ml/100 g/min] with a between-subject standard variation SD(b)=5.5 [ml/100 g/min] and a within-subject standard deviation SD(w)=4.7 [ml/100 g/min]. The corresponding repeatability was 13.0 [ml/100 g/min] and was found to be within the range of previous studies.

Gene Promoter Evolution Targets the Center of the Human Protein Interaction Network

Assessing the contribution of promoters and coding sequences to gene evolution is an important step toward discovering the major genetic determinants of human evolution. Many specific examples have revealed the evolutionary importance of cis-regulatory regions. However, the relative contribution of regulatory and coding regions to the evolutionary process and whether systemic factors differentially influence their evolution remains unclear. To address these questions, we carried out an analysis at the genome scale to identify signatures of positive selection in human proximal promoters. Next, we examined whether genes with positively selected promoters (Prom+ genes) show systemic differences with respect to a set of genes with positively selected protein-coding regions (Cod+ genes). We found that the number of genes in each set was not significantly different (8.1% and 8.5%, respectively). Furthermore, a functional analysis showed that, in both cases, positive selection affects almost all biological processes and only a few genes of each group are located in enriched categories, indicating that promoters and coding regions are not evolutionarily specialized with respect to gene function. On the other hand, we show that the topology of the human protein network has a different influence on the molecular evolution of proximal promoters and coding regions. Notably, Prom+ genes have an unexpectedly high centrality when compared with a reference distribution (P = 0.008, for Eigenvalue centrality). Moreover, the frequency of Prom+ genes increases from the periphery to the center of the protein network (P = 0.02, for the logistic regression coefficient). This means that gene centrality does not constrain the evolution of proximal promoters, unlike the case with coding regions, and further indicates that the evolution of proximal promoters is more efficient in the center of the protein network than in the periphery. These results show that proximal promoters have had a systemic contribution to human evolution by increasing the participation of central genes in the evolutionary process.

A guide to understanding the variation in premiums in rural health insurance marketplaces (RUPRI Center for Rural Health Policy Analysis rural policy brief)

This brief discusses several important factors that should be considered when comparing health insurance plans in the health insurance marketplaces across geographic areas.

Audit report on the Central Iowa Juvenile Detention Center in Eldora, Iowa for the year ended June 30, 2014

Audit report on the Central Iowa Juvenile Detention Center in Eldora, Iowa for the year ended June 30, 2014

Leopold Letter: A Newsletter of the Leopold Center for Sustainable Agriculture, Spring 2015, vol. 27, no.1

The Leopold Center was created by the Iowa Legislature as part of the Iowa Groundwater Protection Act of 1987. The Leopold Center believes contribute to a healthy ways of thinking about markets for Iowa farmers, a better understanding of local ecosystems, public policies and economic practices, and partnerships with consumers.

Pla de màrqueting de Barcelona is golf

El turisme és una de les indústries més importants del país, representant prop de l’11% del PIB espanyol, segons dades de el “Instituto de estudios turísticos” de 2012. Un 86% dels estrangers que visiten el país ho fan per raons vacacionals i són vàries les motivacions que porten a aquests turistes a escollir Espanya i Catalunya per al seu període d’oci: sol i platja, cultura, gastronomia o esports, per exemple. El golf l’inclouríem dintre aquest últim grup. Espanya, té destinacions de turisme de golf que gaudeixen d’una reputació mundial ben merescuda. La Costa el Sol s’emporta un percentatge molt elevat de turisme de golf, seguit per les illes Canàries, les Balears i la Costa Brava. Aquesta última, és una destinació en desenvolupament i que està agafant cada cop més prestigi, tot i que encara està molt allunyada dels números que presenten les altres destinacions que hem comentat, podríem considerar-la ja, com una destinació de golf. En canvi, Barcelona, que segons la Organització Mundial del Turisme és una de les destinacions turístiques més importants del món i que compta amb una molt bona infraestructura de camps de golf, no és reconeguda com una destinació turística de golf i els camps, fins ara, vivien d’esquena al turisme, acomodats en les quotes anuals que els seus socis locals els proporcionaven. Barcelona, a dia d’avui, no figura en cap catàleg de tour operador europeu especialitzat en golf. Per tant, és un repte intentar descobrir si Barcelona pot esdevenir una destinació turística de golf reconeguda i, el que és més important, veure com uns clubs de golf amb una estructura molt arcaica i sense experiència en el sector del turisme, poden encarar aquest nou repte. Resumint, aquest treball ha de respondre a la pregunta; Com es pot crear la marca de golf Barcelona? I també ha de resoldre el: Com s’han d’organitzar els clubs de golf per desenvolupar, tots junts aquest model de negoci? A partir d’aquí vaig començar a estructurar el treball i a intentar respondre aquestes preguntes i d’altres que anaven sortint conforme anava recopilant informació i parlant amb els responsables dels camps de golf

Report on a special investigation of the Center for Behavioral Health for the period January 1, 2011 through May 21, 2013

Report on a special investigation of the Center for Behavioral Health for the period January 1, 2011 through May 21, 2013

Pla de màrqueting: Festivals and Events

La màster tesi consisteix en la creació i desenvolupament del pla de màrqueting del nou producte de Lloret Turisme i el Lloret Convention Bureau, el “Festivals & Events”. A la primera part del treball es fa una presentació de la metodologia seguida, de la presentació del cas, amb l’anàlisi de l’estat de la qüestió i la presentació de l’àmbit d’estudi. Seguidament es procedeix a desenvolupar el cos del treball, és a dir, les diferents parts del pla de màrqueting, així com el desenvolupament de la matriu de la base de dades pel nou producte “Festivals & Events” del Lloret Convention Bureau de Lloret de Mar

Audit report on the City of State Center, Iowa for the year ended June 30, 2014

Audit report on the City of State Center, Iowa for the year ended June 30, 2014

Audit report on the City of Center Point, Iowa for the year ended June 30, 2014

Audit report on the City of Center Point, Iowa for the year ended June 30, 2014

Report on the Iowa Department of Human Services – Central Distribution Center for the year ended June 30, 2014

Report on the Iowa Department of Human Services – Central Distribution Center for the year ended June 30, 2014