Independent Central Banks: Low inflation at no cost?: A model with fiscal policy

In this article we extend the rational partisan model of Alesina and Gatti (1995) to include a second policy, fiscal policy, besides monetary policy. It is shown that, with this extension, the politically induced variance of output is not always eliminated nor reduced by delegating monetary policy to an independent and conservative central bank. Further, in flation and output stabilisation will be affected by the degree of conservativeness of the central bank and by the probability of the less in flation averse party gaining power. Keywords: rational partisan theory; fiscal policy; independent central bank JEL Classi fication: E58, E63.

Vectorisation intra-oculaire [Drug delivery to target the posterior segment of the eye].

Retinal diseases are nowadays the most common causes of vision threatening in developed countries. Therapeutic advances in this field are hindered by the difficulty to deliver drugs to the posterior segment of the eye. Due to anatomical barriers, the ocular biodisponibility of systemically administered drugs remains poor, and topical instillation is not adequate to achieve therapeutic concentrations of drugs in the back of the eye. Ocular drug delivery has thus become one of the main challenges of modern ophthalmology. A multidisciplinary research is being conducted worldwide including pharmacology, biomaterials, ophthalmology, pharmaceutics, and biology. New promising fields have been developed such as implantable or injectable slow release intravitreal devices and degradable polymers, dispersed polymeric systems for intraocular drug delivery, and transscleral delivery devices such as iontophoresis, osmotic pumps or intra-scleraly implantable materials. The first clinical applications emerging from this research are now taking place, opening new avenues for the treatment of retinal diseases.

A plan for an electronic library and information services program for Iowa : presented to the Honorable Terry E. Branstad and members of the Iowa General Assembly, 1995

This document summarizes the conclusions and recommendations of the Library Services Advisory Council who were appointed by Governor Terry E. Branstad to develop a coordinated, cost-effective and comprehensive plan for the implementation of an electronic statewide library and information services program.

State Plan for Library Program under Library Services and Construction Act, as amended, 1966

This document includes the general provisions and regulations of the Iowa Sate Traveling Library under the Library Services and Construction Act. It also includes information of appropriations of funds available for expenditure, authority of local agencies to administer and state agency to supervise local administration and certification.

An efficient algorithm to perform multiple testing in epistasis screening

Background: Research in epistasis or gene-gene interaction detection for human complex traits has grown over the last few years. It has been marked by promising methodological developments, improved translation efforts of statistical epistasis to biological epistasis and attempts to integrate different omics information sources into the epistasis screening to enhance power. The quest for gene-gene interactions poses severe multiple-testing problems. In this context, the maxT algorithm is one technique to control the false-positive rate. However, the memory needed by this algorithm rises linearly with the amount of hypothesis tests. Gene-gene interaction studies will require a memory proportional to the squared number of SNPs. A genome-wide epistasis search would therefore require terabytes of memory. Hence, cache problems are likely to occur, increasing the computation time. In this work we present a new version of maxT, requiring an amount of memory independent from the number of genetic effects to be investigated. This algorithm was implemented in C++ in our epistasis screening software MBMDR-3.0.3. We evaluate the new implementation in terms of memory efficiency and speed using simulated data. The software is illustrated on real-life data for Crohn’s disease. Results: In the case of a binary (affected/unaffected) trait, the parallel workflow of MBMDR-3.0.3 analyzes all gene-gene interactions with a dataset of 100,000 SNPs typed on 1000 individuals within 4 days and 9 hours, using 999 permutations of the trait to assess statistical significance, on a cluster composed of 10 blades, containing each four Quad-Core AMD Opteron(tm) Processor 2352 2.1 GHz. In the case of a continuous trait, a similar run takes 9 days. Our program found 14 SNP-SNP interactions with a multiple-testing corrected p-value of less than 0.05 on real-life Crohn’s disease (CD) data. Conclusions: Our software is the first implementation of the MB-MDR methodology able to solve large-scale SNP-SNP interactions problems within a few days, without using much memory, while adequately controlling the type I error rates. A new implementation to reach genome-wide epistasis screening is under construction. In the context of Crohn’s disease, MBMDR-3.0.3 could identify epistasis involving regions that are well known in the field and could be explained from a biological point of view. This demonstrates the power of our software to find relevant phenotype-genotype higher-order associations.

The Effect of a Physical Activity Program on the Total Number of Primary Care Visits in Inactive Patients: A 15-Month Randomized Controlled Trial

Abstract Background: Effective promotion of exercise could result in substantial savings in healthcare cost expenses in terms of direct medical costs, such as the number of medical appointments. However, this is hampered by our limited knowledge of how to achieve sustained increases in physical activity. Objectives: To assess the effectiveness of a Primary Health Care (PHC) based physical activity program in reducing the total number of visits to the healthcare center among inactive patients, over a 15-month period. Research Design: Randomized controlled trial. Subjects: Three hundred and sixty-two (n = 362) inactive patients suffering from at least one chronic condition were included. One hundred and eighty-three patients (n = 183; mean (SD); 68.3 (8.8) years; 118 women) were randomly allocated to the physical activity program (IG). One hundred and seventy-nine patients (n = 179; 67.2 (9.1) years; 106 women) were allocated to the control group (CG). The IG went through a three-month standardized physical activity program led by physical activity specialists and linked to community resources. Measures: The total number of medical appointments to the PHC, during twelve months before and after the program, was registered. Self-reported health status (SF-12 version 2) was assessed at baseline (month 0), at the end of the intervention (month 3), and at 12 months follow-up after the end of the intervention (month 15). Results: The IG had a significantly reduced number of visits during the 12 months after the intervention: 14.8 (8.5). The CG remained about the same: 18.2 (11.1) (P = .002). Conclusions: Our findings indicate that a 3-month physical activity program linked to community resources is a shortduration, effective and sustainable intervention in inactive patients to decrease rates of PHC visits. Trial Registration: ClinicalTrials.gov NCT00714831

Derechos emergentes en regiones emergentes: el derecho al agua potable y al saneamiento en Asia Central

El derecho humano al agua potable y al saneamiento viene afirmándose de manera cada vez más rotunda en el plano internacional. Supone la capacidad de cada ser humano de acceder a agua limpia y segura de manera asequible, y la obligación correlativa de los Estados de garantizar y proteger este derecho. Los Estados de Asia Central disponen de agua suficiente para garantizar este derecho a todos sus ciudadanos, pero la mala gestión y el despilfarro hace que algunas zonas, sobre todo rurales, tengan importantes carestías. Las mejoras en tarificación, servicio y cooperación transfronteriza se apuntan como posibles vías de solución.

Iowa Local Technical Assistance Program 2010 Summary Report and 2011 Continuation Funding Proposal, HR-296, 2010

This document includes a summary of the initiatives and activities that are ongoing or have been completed by the Iowa Local Technical Assistance Program (LTAP) in 2010. It also contains a request for the 2011 continuation of LTAP funding. A brief history of Iowa LTAP is below. In addition, its mission/vision and objectives are noted and an explanation of the new organization used for this report is provided. The remainder of this document includes a description of the Iowa LTAP operations in 2010 and 2011. More specifically, staffing changes and several major initiatives are presented. This is then followed by a discussion of task-by-task 2010 outcomes and proposed 2011 activities.

2016-2020 Iowa Transportation Improvement Program

This document describes planned investments in Iowa’s multimodal transportation system including aviation, transit, railroads, trails, and highways. This five-year program documents $3.2 billion of highway and bridge construction projects on the primary road system using federal and state funding. Of that funding, a little over $500 million is available due to the passage of Senate File 257 in February 2015. As required by Senate File 257, this program includes a list of the critical highway and bridge projects funded with the additional revenue. As with other recent programs, there continues to be uncertainty in federal funding for roads and bridges. The most recent federal authorization, Moving Ahead for Progress in the 21st Century (MAP-21), will expire July 31, 2015. At the same time that MAP-21 expires and absent Congressional action, the federal Highway Trust Fund will no longer be able to provide funding at current levels. This could result in reduced federal funding reimbursement for projects already underway and/or full elimination of federal highway funding for new projects in federal fiscal year 2016. These two issues provide funding uncertainty with this program in fiscal year 2016 and beyond.

2014 Iowa Public Drinking Water Program Annual Compliance Report, June 2015

This report contains information about Iowa's public drinking water program for the calendar year 2014. Included in the report are descriptions of Iowa's systems, monitoring and reporting requirements of the systems, and violations incurred during the year. This report meets the federal Safe Drinking Water Act's requirement of an annual report on violations of national primary drinking water regulations by public water supply systems in Iowa.

Allohexaploid pearl millet x elephantgrass population potential for a recurrent selection program

The objective of this work was to evaluate the potential of allohexaploid pearl millet x elephantgrass (HGL) population for a recurrent selection program through open-pollinated progenies. Seventy-eight progenies, one representative sample of the population, and two commercial cultivars, Pioneiro and Paraíso, were evaluated in a 9x9 triple lattice design, in two sites. Plant height and dry matter yield were evaluated in three and four cuts, respectively. For plant height, the 17 best progenies were similar to both commercial controls, while for dry matter yield they were higher than 'Paraíso' and lower than 'Pioneiro'. The correlation between progenies and cuts indicated that the fourth cut represents the mean of all cuts, and the possibility of using early selection. Heritability estimates considering cuts and sites were 56.9% for plant height and 58.8% for dry matter yield, and the expected response to selection was 23.4% for dry matter yield and 18.1% for plant height. These results demonstrate the promising HGL population potential for a recurrent selection program.

Parc Central de Nou Barris

El paisatge mediterrani és una terra de llum, de sol i d’ombres, de forta topografia formada per pendents aterrassades i rieres que baixen cap al mar. També és un paisatge amb una extraordinària pressió de l’home. La presencia del home ha estat un fet continuat al llarg de la història. Per tant, és un paisatge completament transformat per l’home. Des de les ciutats fins als camps la presència de l’home és omnipresent i es fa impossible la separació de natura i artifici. En qualsevol cas el fet de que la interacció humana ha estat continuada i estesa al llarg d’un molt extens període de temps, lligat al fet de la lentitud i graduació d’aquests procés de transformació , provoquen dos trets fonamentals: la indiferència d’home i natura i la unicitat del seu paisatge.En el paisatge català podem trobar rastres d’aquest procés per tot arreu. Els Romans van importar els pins que són indissociables del paisatge de la Costa Brava. Els xiprers es plantaven com senyals d’hospitalitat o d’espiritualitat, o bé com a barreres per protegir-se de la Tramuntana. Les palmeres sovint expliquen la historia d’un ‘indiano’ que va fer fortuna a les Amèriques. Les oliveres i les vinyes estan tan arrelades en el paisatge que han acabat per perdre el seu caràcter agrícola i convertir-se en l’essència del Mediterrani, l’antiga aliança entre oli i vi.El suau clima mediterrani també té dues conseqüències importants. La utilització agrícola de la terra amb el subproducte d’una erosió controlada o manipulada des de la topografia natural a una d’artificial. I la especial qualitat de la seva vida urbana fonamentalment a l’aire lliure. Aquesta és probablement la principal contribució a la humanitat: l’ aparició de la polís, de la ciutat. Ciutat entesa en el seu més ampli significat; com lloc de intercanvi, de cultura i de comerç, en resum un lloc d’encontre humà.Molt d’aquest paisatge es conceptualitza en el paisatge Cubista. L’addició de diversos punts de vista i geometries com camps de cultiu, façanes i cobertes de teula, murs de pedra seca, estan emmarcats en una superfície plana que és la tela del pintor. Cezanne va mostrar parcialment aquest potencial en les juxtaposicions i gradacions de color dels paisatges de Gardanne. Finalment Picasso va culminar el manifest Cubista en les seves exultants pintures de paisatges urbans/rurals d’Horta de Sant Joan de l’estiu de 1909. El Paisatge Cubista, utilitzant l’abstracció formal, addiciona la multiplicitat de significats i percepcions del lloc i crea una nova realitat.A l’estratègia cubista d’assignar valors similars a l’home i a la natura explorant les seves qualitats formals hi ha molta de la mateixa qualitat descrita abans en el paisatge Mediterrani. Nogensmenys, tal i com anticipaven els pioners del Moviment Modern, hi ha un gran potencial per a ser aplicat al projecte de paisatge, de ciutat i d’arquitectura.La percepció arquitectònica aplicada a l’ espai urbà ha produït un cert grau d’ originalitat a la pràctica del paisatgisme, fonamentalment en el context urbà, ja sigui en la ciutat tradicional o encara més en els nous territoris de la perifèria urbana.El Parc Central dels arquitectes Arriola&Fiol al districte de Nou Barris a Barcelona es va projectar tenint presents els conceptes exposats abans. L’emplaçament del projecte és el buit resultant de la massiva construcció de blocs d’habitatge durant els anys 60’ i 70’ en una part de Barcelona que fins aquell moment no eren res més que camps de cultiu. A desgrat del tamany del problema la superfície de l’àrea quasi no es pot apreciar com a conseqüència de la organització caòtica dels blocs. El projecte tracta de suggerir un altre paisatge que proposi no tant sols un parc urbà en el centre d’un barri densament poblat sinó també integrar el skyline i la massa construïda dels blocs com una part inseparable i essencial del nou paisatge.www.arriolafiol.com

El problema de las minorías en Xinjiang y sus repercusiones en las Repúblicas de Asia Central

En este trabajo vamos a analizar facetas del renacimiento de las identidades locales y las consecuencias que ello está trayendo en la provincia china de Xinjiang y sus repercusiones en las repúblicas del Asia Central.