Clinical pharmacology of atrial natriuretic (3-28) eicosahexapeptide.

The clinical pharmacology of a synthetic rat atrial natriuretic peptide (rANP) was evaluated in normal volunteers. During a dose-ranging study at 1-40 micrograms/min we observed a dose-dependent decrease in mean intra-arterial blood pressure, an acceleration of the heart rate and a transient increase in blood flow to the skin. During a 4-h constant-dose infusion at 0.5 and 5.0 micrograms/min, inulin clearance remained unchanged but there was a dose-related fall in paraaminohippurate (PAH) clearance and an increase in the filtration fraction. Urinary excretion of sodium, chloride and calcium increased in a dose-related fashion, but with the high dose the excretion curve had a bell-shape. No change in plasma renin activity, angiotensin II and aldosterone was observed during the rANP infusion despite the excretion of large amounts of sodium and a blood pressure reduction with the high dose. Indocyanine green clearance, a measure of hepatic blood flow, was significantly decreased by a 2-h rANP infusion at 1.0 microgram/min. In normal volunteers, therefore, rANP induced vasodilation and blood pressure reduction, a decrease in renal and hepatic blood flow and a natriuretic and transient diuretic effect without activation of the renin-angiotensin-aldosterone system.

La pintura mural romànica: estudi de la tècnica i anàlisi dels materials

Els objectius de partida d’aquesta recerca han estat l’estudi de les tècniques i dels materials dela pintura mural medieval a Catalunya, tot i establint paraŀlelismes amb el coneixement que ensaporten els tractats tècnics d’època medieval. S’ha revisat també l’estat actual del coneixement sobre les tècniques d’alguns conjunts de pintura mural aragonesos i d’àmbit europeu.

MEPDG Work Plan Task No. 5: Characterization of Unbound Materials (Soils/Aggregates) for Mechanistic-Empirical Pavement Design Guide, 2009

The resilient modulus (MR) input parameters in the Mechanistic-Empirical Pavement Design Guide (MEPDG) program have a significant effect on the projected pavement performance. The MEPDG program uses three different levels of inputs depending on the desired level of accuracy. The primary objective of this research was to develop a laboratory testing program utilizing the Iowa DOT servo-hydraulic machine system for evaluating typical Iowa unbound materials and to establish a database of input values for MEPDG analysis. This was achieved by carrying out a detailed laboratory testing program designed in accordance with the AASHTO T307 resilient modulus test protocol using common Iowa unbound materials. The program included laboratory tests to characterize basic physical properties of the unbound materials, specimen preparation and repeated load triaxial tests to determine the resilient modulus. The MEPDG resilient modulus input parameter library for Iowa typical unbound pavement materials was established from the repeated load triaxial MR test results. This library includes the non-linear, stress-dependent resilient modulus model coefficients values for level 1 analysis, the unbound material properties values correlated to resilient modulus for level 2 analysis, and the typical resilient modulus values for level 3 analysis. The resilient modulus input parameters library can be utilized when designing low volume roads in the absence of any basic soil testing. Based on the results of this study, the use of level 2 analysis for MEPDG resilient modulus input is recommended since the repeated load triaxial test for level 1 analysis is complicated, time consuming, expensive, and requires sophisticated equipment and skilled operators.

Un conjunt de materials d'època tardo-republicana de la ciutat romana de Pollentia (Alcúdia, Mallorca)

El pou D 18, situat a la part sud-oest de la zona coneguda del forum de Pollentia, fou amortitzat en el segon quart del segle 1 a.C. EIs materials que formaven part del farciment constitueixen un conjunt tancat representatiu sobretot deIs tipus ceramics locals i d'importació utilitzats en aquesta epoca. El volum principal d'importacions correspon als productes italics, seguits a gran distancia pels materials púnics, iberics i egeus.

Materials lítics prehistòrics de la Cerdanya

Mitjançant la intervenció d'Oriol Mercadal, responsable del Museu Cerda de Puigcerda, han arribat a les nostres mans tres eines lítiques treballades per 1'home, procedents d'un jaciment cereta. La nostra intenció és tan soIs publicar els materials i reflexionar arran de la possible cronologia d'aquestes eines per paral-lels amb altres materials semblants i propers geograficament parlant.

Arquitectura domèstica al Bronze Final i Primera Edat del Ferro a Catalunya: habitacions construïdes amb materials duradors: estat de la qüestió

El present treball es proposa l'estudi fonnal de I'habitat construtt amb materials duradors a Catalunya durant el Bronze Final i la Primera Edat del Ferro, i se centra en l'aninisi dels materials i tecniques de construcció emprats, així com en l' estructura de la casa (planta, dimensions, superfície). Els elements definidors d'aquests habitacles en els períodes estudiats consisteixen en l'ús sistematic de la pedra i la terra com a materials de construcció i la disposició d'habitacions de planta rectangular compartint parets mitgeres, amb poca compartimentació interna i pocs agenc¡:aments al seu interior (llar, forn, banquetes). Les dimensions maximes d'aquestes habitacions no superen, per nonna general, els 20 metres quadrats. La unifonnitat d'aquestes construccions, unida a la poca compartimentació de l'espai, suggereix que ens trobem davant una arquitectura poc especialitzada, que podria correspondre a una societat amb una organització socio-política poc complexa.

Estudi dels materials dipositats en el Museu d"Arqueologia de Catalunya del jaciment ibèric del Castellot de la Roca Roja (Benifallet, Baix Ebre)

El jaciment del Castellot de la Roca Roja (Benifallet, Baix Ebre) es localitza a la riba esquerra del riu Ebre, sobre una formac ió rocallosa de relleus molt abruptes, només accessible per I' extrem septentrional, on es va construir un fossat i una muralla de doble parament que s'adossa a una torre quadranguiar. Sens dubte, la se va posició és immillorable per tal d'exercir el control del pas pel riu.

Les pintures murals de la basílica de "Es Cap des Port" (Fornells, Menorca): materials i tècniques

El present treball ofereix una revisió de les pintures murals de la basílica de «Es Cap des Port» (Fornells, Menorca), així com un estudi de caracterització arqueometrica deIs materials i tecniques per microscopia optica, tant amb lupa binocular com amb micro scopi petrografic mitjanliant ¡¡lmina prima, difracció de raigs X i microscopia electronica de rastreig. Els resultats han permes identificar els pigments emprats, així com la seva tecnica d'aplicació. Igua!ment, han permes caracteritzar els morters i han desvelat l' existencia de dos tipus diferents de suporto Malgrat aquestes diferencies en els morters, els pigments són sempre els mateixos per a tots els conjunts pictorics caracteritzats.

Reactivity of silicate liming materials from Northern Europe assessed by Soil Incubation and two pH Stat methods

Selostus: Pohjois-Euroopan silikaattisten kalkitusaineiden reaktiivisuus astiakoemenetelmällä ja kahdella pH-staattisella menetelmällä arvioituna

Permeability of Granular Subbase Materials, MLR-90-4, 1991

The purpose of this research was to evaluate the materials Iowa uses as a granular subbase and to determine if it provides adequate drainage. Numerous laboratory and in-situ tests were conducted on the materials currently being used in Iowa. The follow conclusions can be made based on the test results: 1. The crushed concrete that is used as a subbase material has a relatively low permeability compared to many other materials used by other states. 2. Further research and tests are needed to find the necessary parameters for crushed concrete to make sure it is providing its optimum drainage and preventing premature damage of the pavement. 3. We have definitely made improvements in drainage in the past few months, but there are many areas that we can improve on that will increase the permeability of this material and insure that the pavement system is safe from premature damage due to water. The current gradation specification for granular subbase material at the start of this study was: Sieve # % Passing 1” 100 #8 10-35 #50 0-15 #200 0-6

CLIL Materials in Chemistry and English: Iodometric Titrations

Content and Language Integrated Learning (CLIL)Materials in Chemistry and English following the principles of CLIL / Content-based Instruction and Task-based Learning

La pintura mural romànica: estudi de la tècnica i anàlisi dels materials

Els objectius de partida d’aquesta recerca han estat l’estudi de les tècniques i dels materials dela pintura mural medieval a Catalunya, tot i establint paraŀlelismes amb el coneixement que ensaporten els tractats tècnics d’època medieval. S’ha revisat també l’estat actual del coneixement sobre les tècniques d’alguns conjunts de pintura mural aragonesos i d’àmbit europeu.

Clinical pharmacology of the angiotensin II receptor antagonist losartan potassium in healthy subjects

INTRODUCTION: The evaluation of a new drug in normotensive volunteers provides important pharmacodynamic and pharmacokinetic information as long as the compound has a specific mechanism of action which can be evaluated in healthy subjects as well as in patients. The purpose of the present paper is to discuss the results that have been obtained in normal volunteers with the specific angiotensin II receptor antagonist, losartan potassium. DOSE-FINDING: Over the last few years, studies in normotensive subjects have demonstrated that the minimal dose of losartan that produces maximal efficacy is 40-80 mg. Losartan has a long duration of action and its ability to produce a sustained blockade of the renin-angiotensin system is due almost exclusively to the active metabolite E3174. HORMONAL EFFECTS: Angiotensin II receptor blockade with losartan induces an expected increase in plasma renin activity and plasma angiotensin II levels. A decrease in plasma aldosterone levels has been found only with a high dose of losartan (120 mg). RENAL AND BLOOD PRESSURE EFFECTS: In normotensive subjects, losartan has little or no effect on blood pressure unless the subjects are markedly salt-depleted. Losartan causes no change in the glomerular filtration rate and either no modification or only a slight increase in renal blood flow. Losartan significantly increases urinary sodium excretion, however, and surprisingly produces a transient rise in urinary potassium excretion. Finally, losartan increases uric acid excretion and lowers plasma uric acid levels. CONCLUSIONS: These results suggest that losartan is an effective angiotensin II receptor antagonist in normal subjects. Its safety and clinical efficacy in hypertensive patients will be addressed in large clinical trials.

Lime or Chloride Treatment of Granular Base Course Materials, HR-99

Results are presented of triaxial testing of three crushed limestones to which either hydrated high-calcium lime, sodium chloride or calcium chloride had been added. Lime was added at rates of 1, 3, 10 and 16 percent, chlorides were added at 0.5 percent rate only. Speciments were compacted using vibratory compaction apparatus and were tested in triaxial compression using lateral pressures from 10 to 100 psi. Triaxial test results indicate that: (1) sodium chloride slightly decreased the angle of internal friction and increased cohesion, (2) calcium chloride slightly increased the angle of internal friction and decreased cohesion, and (3) lime had no appreciable effect on angle of internal friction but increased cohesion, decreased density and increased pore water pressure.